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Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

Crowther-Swanepoel, Dalemari ; Broderick, Peter ; Di Bernardo, Maria Chiara ; Dobbins, Sara E. ; Torres, Maria ; Mansouri, Mahmoud ; Ruiz-Ponte, Clara ; Enjuanes, Anna ; Rosenquist, Richard and Carracedo, Angel , et al. (2010) In Nature Genetics 42(2). p.59-132
Abstract
To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.
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Contribution to journal
publication status
published
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Nature Genetics
volume
42
issue
2
pages
59 - 132
publisher
Nature Publishing Group
external identifiers
  • wos:000274084400009
  • scopus:75749138023
  • pmid:20062064
ISSN
1546-1718
DOI
10.1038/ng.510
language
English
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yes
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The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)
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8b59d16a-a407-43ca-abbb-3a7a98c33950 (old id 1569837)
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2016-04-01 14:40:14
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@article{8b59d16a-a407-43ca-abbb-3a7a98c33950,
  abstract     = {To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.},
  author       = {Crowther-Swanepoel, Dalemari and Broderick, Peter and Di Bernardo, Maria Chiara and Dobbins, Sara E. and Torres, Maria and Mansouri, Mahmoud and Ruiz-Ponte, Clara and Enjuanes, Anna and Rosenquist, Richard and Carracedo, Angel and Jurlander, Jesper and Campo, Elias and Juliusson, Gunnar and Montserrat, Emilio and Smedby, Karin E. and Dyer, Martin J. S. and Matutes, Estella and Dearden, Claire and Sunter, Nicola J. and Hall, Andrew G. and Mainou-Fowler, Tryfonia and Jackson, Graham H. and Summerfield, Geoffrey and Harris, Robert J. and Pettitt, Andrew R. and Allsup, David J. and Bailey, James R. and Pratt, Guy and Pepper, Chris and Fegan, Chris and Parker, Anton and Oscier, David and Allan, James M. and Catovsky, Daniel and Houlston, Richard S.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {2},
  pages        = {59--132},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk},
  url          = {http://dx.doi.org/10.1038/ng.510},
  doi          = {10.1038/ng.510},
  volume       = {42},
  year         = {2010},
}