Monkeypox : Immune response, vaccination and preventive efforts
(2022) In Narra J 2(3).- Abstract
Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to... (More)
Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.
(Less)
- author
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- emerging viral infectious disease, Monkeypox virus, MPXV, outbreak, zoonosis
- in
- Narra J
- volume
- 2
- issue
- 3
- article number
- e90
- publisher
- Narra Sains Indonesia
- external identifiers
-
- scopus:85143122544
- ISSN
- 2807-2618
- DOI
- 10.52225/narra.v2i3.90
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2022, School of Medicine, Universitas Syiah Kuala. All rights reserved.
- id
- 8b641c12-f229-4aa0-87c1-779c5b3342e0
- date added to LUP
- 2024-10-16 09:46:19
- date last changed
- 2025-04-04 14:28:44
@article{8b641c12-f229-4aa0-87c1-779c5b3342e0,
abstract = {{<p>Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.</p>}},
author = {{Ophinni, Youdiil and Frediansyah, Andri and Sirinam, Salin and Megawati, Dewi and Stoian, Ana M. and Enitan, Seyi S. and Akele, Richard Y. and Sah, Ranjit and Pongpirul, Krit and Abdeen, Ziad and Aghayeva, Sevda and Ikram, Aamer and Kebede, Yohannes and Wollina, Uwe and Subbaram, Kannan and Koyanagi, Ai and Serouri, Abdulwahed Al and Nguendo-Yongsi, H. Blaise and Edwards, Jeffrey and Sallam, Dina E. and Khader, Yousef and Viveiros-Rosa, Sandro G. and Memish, Ziad A. and Amir-Behghadami, Mehrdad and Vento, Sandro and Rademaker, Marius and Sallam, Malik}},
issn = {{2807-2618}},
keywords = {{emerging viral infectious disease; Monkeypox virus; MPXV; outbreak; zoonosis}},
language = {{eng}},
number = {{3}},
publisher = {{Narra Sains Indonesia}},
series = {{Narra J}},
title = {{Monkeypox : Immune response, vaccination and preventive efforts}},
url = {{http://dx.doi.org/10.52225/narra.v2i3.90}},
doi = {{10.52225/narra.v2i3.90}},
volume = {{2}},
year = {{2022}},
}