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Genetics of type 2 diabetes : It matters from which parent we inherit the risk

Lyssenko, Valeriya LU ; Groop, Leif LU and Prasad, Rashmi B. LU (2015) In Review of Diabetic Studies 12(3-4). p.233-242
Abstract

Type 2 diabetes (T2D) results from a co-occurrence of genes and environmental factors. There are more than 120 genetic loci suggested to be associated with T2D, or with glucose and insulin levels in European and multi-ethnic populations. Risk of T2D is higher in the offspring if the mother rather than the father has T2D. Genetically, this can be associated with a unique parent-of-origin (PoO) transmission of risk alleles, and it relates to genetic programming during the intrauterine period, resulting in the inability to increase insulin secretion in response to increased demands imposed by insulin resistance later in life. Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes. Here we... (More)

Type 2 diabetes (T2D) results from a co-occurrence of genes and environmental factors. There are more than 120 genetic loci suggested to be associated with T2D, or with glucose and insulin levels in European and multi-ethnic populations. Risk of T2D is higher in the offspring if the mother rather than the father has T2D. Genetically, this can be associated with a unique parent-of-origin (PoO) transmission of risk alleles, and it relates to genetic programming during the intrauterine period, resulting in the inability to increase insulin secretion in response to increased demands imposed by insulin resistance later in life. Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes. Here we describe T2D susceptibility genes associated with defects in insulin secretion, and thereby risk of overt T2D. This review emphasizes the need to consider distorted parental transmission of risk alleles by exploring the genetic risk of T2D.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Heritability, Parent-of-origin, Risk allele, Single nucleotide polymorphism, SNP, Type 2 diabetes
in
Review of Diabetic Studies
volume
12
issue
3-4
pages
10 pages
external identifiers
  • Scopus:84982260934
ISSN
1613-6071
DOI
10.1900/RDS.2015.12.233
language
English
LU publication?
yes
id
8b7aabb1-a0b5-4835-87b5-ef5bb8c2a7ab
date added to LUP
2016-09-05 11:34:31
date last changed
2017-01-09 11:43:07
@article{8b7aabb1-a0b5-4835-87b5-ef5bb8c2a7ab,
  abstract     = {<p>Type 2 diabetes (T2D) results from a co-occurrence of genes and environmental factors. There are more than 120 genetic loci suggested to be associated with T2D, or with glucose and insulin levels in European and multi-ethnic populations. Risk of T2D is higher in the offspring if the mother rather than the father has T2D. Genetically, this can be associated with a unique parent-of-origin (PoO) transmission of risk alleles, and it relates to genetic programming during the intrauterine period, resulting in the inability to increase insulin secretion in response to increased demands imposed by insulin resistance later in life. Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes. Here we describe T2D susceptibility genes associated with defects in insulin secretion, and thereby risk of overt T2D. This review emphasizes the need to consider distorted parental transmission of risk alleles by exploring the genetic risk of T2D.</p>},
  author       = {Lyssenko, Valeriya and Groop, Leif and Prasad, Rashmi B.},
  issn         = {1613-6071},
  keyword      = {Heritability,Parent-of-origin,Risk allele,Single nucleotide polymorphism,SNP,Type 2 diabetes},
  language     = {eng},
  number       = {3-4},
  pages        = {233--242},
  series       = {Review of Diabetic Studies},
  title        = {Genetics of type 2 diabetes : It matters from which parent we inherit the risk},
  url          = {http://dx.doi.org/10.1900/RDS.2015.12.233},
  volume       = {12},
  year         = {2015},
}