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Indexing haemodynamic variables in young children

Sigurdsson, Theodor S. LU and Lindberg, Lars LU (2021) In Acta Anaesthesiologica Scandinavica 65(2). p.195-202
Abstract

Background: Haemodynamic studies in children are rare and most studies have included few subjects in the youngest age group. Haemodynamic variables need to be indexed to establish a reference of normality that is valid in all populations. The traditional way to index haemodynamic variables with body surface area (BSA) is complicated in young children due to its non-linear relationship with body weight (BW). We examined several haemodynamic variables in children by indexing them with BSA and BW. Methods: A single-centre, observational cohort study comparing non-indexed and indexed haemodynamic variables in children undergoing heart surgery (divided into three weight groups: 1-5 kg, >5-10 kg and >10-15 kg). Results: A total of 68... (More)

Background: Haemodynamic studies in children are rare and most studies have included few subjects in the youngest age group. Haemodynamic variables need to be indexed to establish a reference of normality that is valid in all populations. The traditional way to index haemodynamic variables with body surface area (BSA) is complicated in young children due to its non-linear relationship with body weight (BW). We examined several haemodynamic variables in children by indexing them with BSA and BW. Methods: A single-centre, observational cohort study comparing non-indexed and indexed haemodynamic variables in children undergoing heart surgery (divided into three weight groups: 1-5 kg, >5-10 kg and >10-15 kg). Results: A total of 68 children were included in this study, mean age 11.1 months ± 11.1 month (range 0 to 43 months). All haemodynamic variables, cardiac output (CO), stroke volume (SV), total end-diastolic volume (TEDV), central blood volume (CBV) and active circulation volume (ACV), increased with weight without indexing (P <.05). Indexing variables with BW produced a more linear relationship for all haemodynamic variables between weight groups than BSA. The mean BSA-indexed haemodynamic values were CIBSA 3.5 ± 1.1 L/min/m2 and SVIBSA 27.3 ± 8.9 ml/min/m2. The mean BW-indexed haemodynamic values were CIBW 180 ± 50 ml/min/kg and SVIBW 1.34 ± 0.38 ml/kg. Blood volume variables indexed with BW were TEDVBW 12.0 ± 2.8 ml/kg, CBVBW 21.3 ± 6.6 ml/kg and ACVBW 70.3 ± 15.2 ml/kg. Conclusions: Indexing haemodynamic variables with BW produces a more appropriate body size-independent scale in young children than BSA. Summary statement: In this study, we studied indexing of haemodynamic variables and estimation of blood volumes in young children undergoing corrective heart surgery using an indicator dilution technology.

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author
and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood volume, body surface area, body weight, cardiac output, children, indexing
in
Acta Anaesthesiologica Scandinavica
volume
65
issue
2
pages
195 - 202
publisher
Wiley-Blackwell
external identifiers
  • scopus:85094667167
  • pmid:33015826
ISSN
0001-5172
DOI
10.1111/aas.13720
language
English
LU publication?
no
id
8b7f3fc4-9bec-448b-bc6c-30e156b5a1e2
date added to LUP
2020-11-23 08:32:19
date last changed
2024-06-13 00:23:09
@article{8b7f3fc4-9bec-448b-bc6c-30e156b5a1e2,
  abstract     = {{<p>Background: Haemodynamic studies in children are rare and most studies have included few subjects in the youngest age group. Haemodynamic variables need to be indexed to establish a reference of normality that is valid in all populations. The traditional way to index haemodynamic variables with body surface area (BSA) is complicated in young children due to its non-linear relationship with body weight (BW). We examined several haemodynamic variables in children by indexing them with BSA and BW. Methods: A single-centre, observational cohort study comparing non-indexed and indexed haemodynamic variables in children undergoing heart surgery (divided into three weight groups: 1-5 kg, &gt;5-10 kg and &gt;10-15 kg). Results: A total of 68 children were included in this study, mean age 11.1 months ± 11.1 month (range 0 to 43 months). All haemodynamic variables, cardiac output (CO), stroke volume (SV), total end-diastolic volume (TEDV), central blood volume (CBV) and active circulation volume (ACV), increased with weight without indexing (P &lt;.05). Indexing variables with BW produced a more linear relationship for all haemodynamic variables between weight groups than BSA. The mean BSA-indexed haemodynamic values were CI<sub>BSA</sub> 3.5 ± 1.1 L/min/m<sup>2</sup> and SVI<sub>BSA</sub> 27.3 ± 8.9 ml/min/m<sup>2</sup>. The mean BW-indexed haemodynamic values were CI<sub>BW</sub> 180 ± 50 ml/min/kg and SVI<sub>BW</sub> 1.34 ± 0.38 ml/kg. Blood volume variables indexed with BW were TEDV<sub>BW</sub> 12.0 ± 2.8 ml/kg, CBV<sub>BW</sub> 21.3 ± 6.6 ml/kg and ACV<sub>BW</sub> 70.3 ± 15.2 ml/kg. Conclusions: Indexing haemodynamic variables with BW produces a more appropriate body size-independent scale in young children than BSA. Summary statement: In this study, we studied indexing of haemodynamic variables and estimation of blood volumes in young children undergoing corrective heart surgery using an indicator dilution technology.</p>}},
  author       = {{Sigurdsson, Theodor S. and Lindberg, Lars}},
  issn         = {{0001-5172}},
  keywords     = {{blood volume; body surface area; body weight; cardiac output; children; indexing}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{195--202}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Anaesthesiologica Scandinavica}},
  title        = {{Indexing haemodynamic variables in young children}},
  url          = {{http://dx.doi.org/10.1111/aas.13720}},
  doi          = {{10.1111/aas.13720}},
  volume       = {{65}},
  year         = {{2021}},
}