Indexing haemodynamic variables in young children
(2021) In Acta Anaesthesiologica Scandinavica 65(2). p.195-202- Abstract
Background: Haemodynamic studies in children are rare and most studies have included few subjects in the youngest age group. Haemodynamic variables need to be indexed to establish a reference of normality that is valid in all populations. The traditional way to index haemodynamic variables with body surface area (BSA) is complicated in young children due to its non-linear relationship with body weight (BW). We examined several haemodynamic variables in children by indexing them with BSA and BW. Methods: A single-centre, observational cohort study comparing non-indexed and indexed haemodynamic variables in children undergoing heart surgery (divided into three weight groups: 1-5 kg, >5-10 kg and >10-15 kg). Results: A total of 68... (More)
Background: Haemodynamic studies in children are rare and most studies have included few subjects in the youngest age group. Haemodynamic variables need to be indexed to establish a reference of normality that is valid in all populations. The traditional way to index haemodynamic variables with body surface area (BSA) is complicated in young children due to its non-linear relationship with body weight (BW). We examined several haemodynamic variables in children by indexing them with BSA and BW. Methods: A single-centre, observational cohort study comparing non-indexed and indexed haemodynamic variables in children undergoing heart surgery (divided into three weight groups: 1-5 kg, >5-10 kg and >10-15 kg). Results: A total of 68 children were included in this study, mean age 11.1 months ± 11.1 month (range 0 to 43 months). All haemodynamic variables, cardiac output (CO), stroke volume (SV), total end-diastolic volume (TEDV), central blood volume (CBV) and active circulation volume (ACV), increased with weight without indexing (P <.05). Indexing variables with BW produced a more linear relationship for all haemodynamic variables between weight groups than BSA. The mean BSA-indexed haemodynamic values were CIBSA 3.5 ± 1.1 L/min/m2 and SVIBSA 27.3 ± 8.9 ml/min/m2. The mean BW-indexed haemodynamic values were CIBW 180 ± 50 ml/min/kg and SVIBW 1.34 ± 0.38 ml/kg. Blood volume variables indexed with BW were TEDVBW 12.0 ± 2.8 ml/kg, CBVBW 21.3 ± 6.6 ml/kg and ACVBW 70.3 ± 15.2 ml/kg. Conclusions: Indexing haemodynamic variables with BW produces a more appropriate body size-independent scale in young children than BSA. Summary statement: In this study, we studied indexing of haemodynamic variables and estimation of blood volumes in young children undergoing corrective heart surgery using an indicator dilution technology.
(Less)
- author
- Sigurdsson, Theodor S. LU and Lindberg, Lars LU
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- blood volume, body surface area, body weight, cardiac output, children, indexing
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 65
- issue
- 2
- pages
- 195 - 202
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:33015826
- scopus:85094667167
- ISSN
- 0001-5172
- DOI
- 10.1111/aas.13720
- language
- English
- LU publication?
- no
- id
- 8b7f3fc4-9bec-448b-bc6c-30e156b5a1e2
- date added to LUP
- 2020-11-23 08:32:19
- date last changed
- 2024-09-19 09:38:00
@article{8b7f3fc4-9bec-448b-bc6c-30e156b5a1e2, abstract = {{<p>Background: Haemodynamic studies in children are rare and most studies have included few subjects in the youngest age group. Haemodynamic variables need to be indexed to establish a reference of normality that is valid in all populations. The traditional way to index haemodynamic variables with body surface area (BSA) is complicated in young children due to its non-linear relationship with body weight (BW). We examined several haemodynamic variables in children by indexing them with BSA and BW. Methods: A single-centre, observational cohort study comparing non-indexed and indexed haemodynamic variables in children undergoing heart surgery (divided into three weight groups: 1-5 kg, >5-10 kg and >10-15 kg). Results: A total of 68 children were included in this study, mean age 11.1 months ± 11.1 month (range 0 to 43 months). All haemodynamic variables, cardiac output (CO), stroke volume (SV), total end-diastolic volume (TEDV), central blood volume (CBV) and active circulation volume (ACV), increased with weight without indexing (P <.05). Indexing variables with BW produced a more linear relationship for all haemodynamic variables between weight groups than BSA. The mean BSA-indexed haemodynamic values were CI<sub>BSA</sub> 3.5 ± 1.1 L/min/m<sup>2</sup> and SVI<sub>BSA</sub> 27.3 ± 8.9 ml/min/m<sup>2</sup>. The mean BW-indexed haemodynamic values were CI<sub>BW</sub> 180 ± 50 ml/min/kg and SVI<sub>BW</sub> 1.34 ± 0.38 ml/kg. Blood volume variables indexed with BW were TEDV<sub>BW</sub> 12.0 ± 2.8 ml/kg, CBV<sub>BW</sub> 21.3 ± 6.6 ml/kg and ACV<sub>BW</sub> 70.3 ± 15.2 ml/kg. Conclusions: Indexing haemodynamic variables with BW produces a more appropriate body size-independent scale in young children than BSA. Summary statement: In this study, we studied indexing of haemodynamic variables and estimation of blood volumes in young children undergoing corrective heart surgery using an indicator dilution technology.</p>}}, author = {{Sigurdsson, Theodor S. and Lindberg, Lars}}, issn = {{0001-5172}}, keywords = {{blood volume; body surface area; body weight; cardiac output; children; indexing}}, language = {{eng}}, number = {{2}}, pages = {{195--202}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Anaesthesiologica Scandinavica}}, title = {{Indexing haemodynamic variables in young children}}, url = {{http://dx.doi.org/10.1111/aas.13720}}, doi = {{10.1111/aas.13720}}, volume = {{65}}, year = {{2021}}, }