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Side localization of parathyroid adenomas by simplified intraoperative venous sampling for parathyroid hormone

Bergenfelz, A LU ; Algotsson, L LU ; Roth, Bengt LU ; Isaksson, A LU and Tibblin, Sten (1996) In World Journal of Surgery 20(3). p.60-358
Abstract

Side localization of parathyroid adenomas was performed by venous sampling for intact parathyroid hormone (PTH) in 20 consecutive patients with primary hyperparathyroidism (pHPT) after induction of anesthesia. The results were thus available during surgery. Nineteen of the patients had solitary parathyroid adenoma, and one had hyperplasia. There was no complication to the procedure. A lateralizing PTH gradient for a parathyroid adenoma was obtained in 13 patients. At surgery 12 of them (92%) were proved correct; that is, the adenoma was localized on the same side. Thus the technique correctly lateralized the adenoma in 12 of 19 patients (63%). We therefore conclude that the method of intraoperative venous sampling for intact PTH is... (More)

Side localization of parathyroid adenomas was performed by venous sampling for intact parathyroid hormone (PTH) in 20 consecutive patients with primary hyperparathyroidism (pHPT) after induction of anesthesia. The results were thus available during surgery. Nineteen of the patients had solitary parathyroid adenoma, and one had hyperplasia. There was no complication to the procedure. A lateralizing PTH gradient for a parathyroid adenoma was obtained in 13 patients. At surgery 12 of them (92%) were proved correct; that is, the adenoma was localized on the same side. Thus the technique correctly lateralized the adenoma in 12 of 19 patients (63%). We therefore conclude that the method of intraoperative venous sampling for intact PTH is safe, and the predictive value of a lateralizing gradient is high. It could therefore be used as an adjunct to surgical skill and noninvasive localization procedures in selected cases, for instance in patients with prior neck surgery and hypercalcemic crisis.

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Contribution to journal
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published
subject
keywords
Adenoma, Adult, Aged, Female, Humans, Intraoperative Complications, Male, Middle Aged, Parathyroid Hormone, Parathyroid Neoplasms, Parathyroidectomy, Veins, Journal Article, Research Support, Non-U.S. Gov't
in
World Journal of Surgery
volume
20
issue
3
pages
3 pages
publisher
Springer
external identifiers
  • scopus:0030004513
ISSN
0364-2313
DOI
10.1007/s002689900058
language
English
LU publication?
yes
id
8b8e6901-acc5-428b-a4ca-6f7237b366bd
date added to LUP
2017-05-10 17:40:53
date last changed
2017-07-23 05:28:07
@article{8b8e6901-acc5-428b-a4ca-6f7237b366bd,
  abstract     = {<p>Side localization of parathyroid adenomas was performed by venous sampling for intact parathyroid hormone (PTH) in 20 consecutive patients with primary hyperparathyroidism (pHPT) after induction of anesthesia. The results were thus available during surgery. Nineteen of the patients had solitary parathyroid adenoma, and one had hyperplasia. There was no complication to the procedure. A lateralizing PTH gradient for a parathyroid adenoma was obtained in 13 patients. At surgery 12 of them (92%) were proved correct; that is, the adenoma was localized on the same side. Thus the technique correctly lateralized the adenoma in 12 of 19 patients (63%). We therefore conclude that the method of intraoperative venous sampling for intact PTH is safe, and the predictive value of a lateralizing gradient is high. It could therefore be used as an adjunct to surgical skill and noninvasive localization procedures in selected cases, for instance in patients with prior neck surgery and hypercalcemic crisis.</p>},
  author       = {Bergenfelz, A and Algotsson, L and Roth, Bengt and Isaksson, A and Tibblin, Sten},
  issn         = {0364-2313},
  keyword      = {Adenoma,Adult,Aged,Female,Humans,Intraoperative Complications,Male,Middle Aged,Parathyroid Hormone,Parathyroid Neoplasms,Parathyroidectomy,Veins,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {60--358},
  publisher    = {Springer},
  series       = {World Journal of Surgery},
  title        = {Side localization of parathyroid adenomas by simplified intraoperative venous sampling for parathyroid hormone},
  url          = {http://dx.doi.org/10.1007/s002689900058},
  volume       = {20},
  year         = {1996},
}