Clinical outcomes in combination versus mono antibiotic therapy in ICU admitted patients with a suspected infection - A substudy of the DIANA study
Tanha, Nima LU ; Areskog Lejbman, Ilja LU ; De Bus, Liesbet ; De Pascale, Gennaro ; Garnacho-Montero, Jose ; Leone, Marc ; Fujitani, Shigeki ; De Waele, Jan J. ; Torisson, Gustav LU
and Sjövall, Fredrik
LU
(2024)
In Journal of Critical Care
80.
p.1-6
- Abstract
- Purpose
In a retrospective cohort study of intensive care unit (ICU) admitted adult patients with suspected or confirmed infection, associations between combination versus mono empirical antibiotic therapy and clinical cure at day 7 as well as mortality at day 7 and 28, were investigated.
Materials and methods
Patients from the DIANA study were grouped and analysed by combination versus mono antibiotic therapy. Clinical cure was defined as survival and resolution of all signs and symptoms related to the infection. Odds ratios (ORs) were calculated by logistic regression analyses.
Results
Of the 1398 included patients, 568 patients (41%) received combination therapy. In total, 641(46%) patients achieved... (More) - Purpose
In a retrospective cohort study of intensive care unit (ICU) admitted adult patients with suspected or confirmed infection, associations between combination versus mono empirical antibiotic therapy and clinical cure at day 7 as well as mortality at day 7 and 28, were investigated.
Materials and methods
Patients from the DIANA study were grouped and analysed by combination versus mono antibiotic therapy. Clinical cure was defined as survival and resolution of all signs and symptoms related to the infection. Odds ratios (ORs) were calculated by logistic regression analyses.
Results
Of the 1398 included patients, 568 patients (41%) received combination therapy. In total, 641(46%) patients achieved clinical cure and 135 (10%) patients had died as of day 7. There were no significant associations between combination and mono therapy relating to clinical cure and mortality.
Conclusions
This study found no differences in clinical cure and mortality between empirical combination versus mono therapy in a large cohort of ICU patients with a suspected infection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8ba34d23-161f-4a87-8077-e5c78fc367e5
- author
- Tanha, Nima
LU
; Areskog Lejbman, Ilja
LU
; De Bus, Liesbet
; De Pascale, Gennaro
; Garnacho-Montero, Jose
; Leone, Marc
; Fujitani, Shigeki
; De Waele, Jan J.
; Torisson, Gustav
LU
and Sjövall, Fredrik
LU
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- in
- Journal of Critical Care
- volume
- 80
- article number
- 154501
- pages
- 1 - 6
- publisher
- Elsevier
- external identifiers
-
- scopus:85180610070
- pmid:38128219
- ISSN
- 1557-8615
- DOI
- 10.1016/j.jcrc.2023.154501
- language
- English
- LU publication?
- no
- id
- 8ba34d23-161f-4a87-8077-e5c78fc367e5
- date added to LUP
- 2024-02-26 20:33:10
- date last changed
- 2024-02-28 03:00:27
@article{8ba34d23-161f-4a87-8077-e5c78fc367e5,
abstract = {{Purpose<br/>In a retrospective cohort study of intensive care unit (ICU) admitted adult patients with suspected or confirmed infection, associations between combination versus mono empirical antibiotic therapy and clinical cure at day 7 as well as mortality at day 7 and 28, were investigated.<br/><br/>Materials and methods<br/>Patients from the DIANA study were grouped and analysed by combination versus mono antibiotic therapy. Clinical cure was defined as survival and resolution of all signs and symptoms related to the infection. Odds ratios (ORs) were calculated by logistic regression analyses.<br/><br/>Results<br/>Of the 1398 included patients, 568 patients (41%) received combination therapy. In total, 641(46%) patients achieved clinical cure and 135 (10%) patients had died as of day 7. There were no significant associations between combination and mono therapy relating to clinical cure and mortality.<br/><br/>Conclusions<br/>This study found no differences in clinical cure and mortality between empirical combination versus mono therapy in a large cohort of ICU patients with a suspected infection.}},
author = {{Tanha, Nima and Areskog Lejbman, Ilja and De Bus, Liesbet and De Pascale, Gennaro and Garnacho-Montero, Jose and Leone, Marc and Fujitani, Shigeki and De Waele, Jan J. and Torisson, Gustav and Sjövall, Fredrik}},
issn = {{1557-8615}},
language = {{eng}},
pages = {{1--6}},
publisher = {{Elsevier}},
series = {{Journal of Critical Care}},
title = {{Clinical outcomes in combination versus mono antibiotic therapy in ICU admitted patients with a suspected infection - A substudy of the DIANA study}},
url = {{http://dx.doi.org/10.1016/j.jcrc.2023.154501}},
doi = {{10.1016/j.jcrc.2023.154501}},
volume = {{80}},
year = {{2024}},
}