Assembling responsive microgels at responsive lipid membranes
(2019) In Proceedings of the National Academy of Sciences of the United States of America 116(12). p.5442-5450- Abstract
Directed colloidal self-assembly at fluid interfaces can have a large impact in the fields of nanotechnology, materials, and biomedical sciences. The ability to control interfacial self-assembly relies on the fine interplay between bulk and surface interactions. Here, we investigate the interfacial assembly of thermoresponsive microgels and lipogels at the surface of giant unilamellar vesicles (GUVs) consisting of phospholipids bilayers with different compositions. By altering the properties of the lipid membrane and the microgel particles, it is possible to control the adsorption/desorption processes as well as the organization and dynamics of the colloids at the vesicle surface. No translocation of the microgels and lipogels through... (More)
Directed colloidal self-assembly at fluid interfaces can have a large impact in the fields of nanotechnology, materials, and biomedical sciences. The ability to control interfacial self-assembly relies on the fine interplay between bulk and surface interactions. Here, we investigate the interfacial assembly of thermoresponsive microgels and lipogels at the surface of giant unilamellar vesicles (GUVs) consisting of phospholipids bilayers with different compositions. By altering the properties of the lipid membrane and the microgel particles, it is possible to control the adsorption/desorption processes as well as the organization and dynamics of the colloids at the vesicle surface. No translocation of the microgels and lipogels through the membrane was observed for any of the membrane compositions and temperatures investigated. The lipid membranes with fluid chains provide highly dynamic interfaces that can host and mediate long-range ordering into 2D hexagonal crystals. This is in clear contrast to the conditions when the membranes are composed of lipids with solid chains, where there is no crystalline arrangement, and most of the particles desorb from the membrane. Likewise, we show that in segregated membranes, the soft microgel colloids form closely packed 2D crystals on the fluid bilayer domains, while hardly any particles adhere to the more solid bilayer domains. These findings thus present an approach for selective and controlled colloidal assembly at lipid membranes, opening routes toward the development of tunable soft materials.
(Less)
- author
- Wang, Meina LU ; Mihut, Adriana M LU ; Rieloff, Ellen LU ; Dabkowska, Aleksandra P LU ; Månsson, Linda K LU ; Immink, Jasper N LU ; Sparr, Emma LU and Crassous, Jérôme J
- organization
- publishing date
- 2019-03-19
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences of the United States of America
- volume
- 116
- issue
- 12
- pages
- 9 pages
- publisher
- National Academy of Sciences
- external identifiers
-
- scopus:85063272288
- pmid:30824593
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.1807790116
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2019 the Author(s). Published by PNAS.
- id
- 8be4f30c-9ab3-4d2d-bed9-8a817d8b1685
- date added to LUP
- 2019-03-29 12:03:42
- date last changed
- 2024-05-15 03:15:58
@article{8be4f30c-9ab3-4d2d-bed9-8a817d8b1685,
abstract = {{<p>Directed colloidal self-assembly at fluid interfaces can have a large impact in the fields of nanotechnology, materials, and biomedical sciences. The ability to control interfacial self-assembly relies on the fine interplay between bulk and surface interactions. Here, we investigate the interfacial assembly of thermoresponsive microgels and lipogels at the surface of giant unilamellar vesicles (GUVs) consisting of phospholipids bilayers with different compositions. By altering the properties of the lipid membrane and the microgel particles, it is possible to control the adsorption/desorption processes as well as the organization and dynamics of the colloids at the vesicle surface. No translocation of the microgels and lipogels through the membrane was observed for any of the membrane compositions and temperatures investigated. The lipid membranes with fluid chains provide highly dynamic interfaces that can host and mediate long-range ordering into 2D hexagonal crystals. This is in clear contrast to the conditions when the membranes are composed of lipids with solid chains, where there is no crystalline arrangement, and most of the particles desorb from the membrane. Likewise, we show that in segregated membranes, the soft microgel colloids form closely packed 2D crystals on the fluid bilayer domains, while hardly any particles adhere to the more solid bilayer domains. These findings thus present an approach for selective and controlled colloidal assembly at lipid membranes, opening routes toward the development of tunable soft materials.</p>}},
author = {{Wang, Meina and Mihut, Adriana M and Rieloff, Ellen and Dabkowska, Aleksandra P and Månsson, Linda K and Immink, Jasper N and Sparr, Emma and Crassous, Jérôme J}},
issn = {{1091-6490}},
language = {{eng}},
month = {{03}},
number = {{12}},
pages = {{5442--5450}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences of the United States of America}},
title = {{Assembling responsive microgels at responsive lipid membranes}},
url = {{http://dx.doi.org/10.1073/pnas.1807790116}},
doi = {{10.1073/pnas.1807790116}},
volume = {{116}},
year = {{2019}},
}