Advanced

Sources of eicosanoid precursor fatty acid pools in tissues

Zhou, L LU and Nilsson, Åke LU (2001) In Journal of Lipid Research 42(10). p.1521-1542
Abstract

Tissue arachidonic acid (AA) pools originate from the diet, and from hepatic and extrahepatic desaturation-elongation of dietary linoleic acid (LA). This review summarizes the roles of absorption, transport, and formation of AA in the buildup of tissue AA pools. In humans who ingest 0.2-0.3 g of AA and 10-20 g of LA per day on a Western diet, the formation of AA from LA exceeds the dietary supply of AA. A number of factors favor the partitioning of AA to tissue phospholipids rather than adipose tissue and plasma triglycerides. The characteristics of AA transport with lipoproteins are discussed with focus on the role of lipoprotein lipase, lecithin:cholesterol acyltransferase, hepatic lipase, and the scavenger receptor BI and LDL... (More)

Tissue arachidonic acid (AA) pools originate from the diet, and from hepatic and extrahepatic desaturation-elongation of dietary linoleic acid (LA). This review summarizes the roles of absorption, transport, and formation of AA in the buildup of tissue AA pools. In humans who ingest 0.2-0.3 g of AA and 10-20 g of LA per day on a Western diet, the formation of AA from LA exceeds the dietary supply of AA. A number of factors favor the partitioning of AA to tissue phospholipids rather than adipose tissue and plasma triglycerides. The characteristics of AA transport with lipoproteins are discussed with focus on the role of lipoprotein lipase, lecithin:cholesterol acyltransferase, hepatic lipase, and the scavenger receptor BI and LDL receptors in tissue uptake of AA. Liver-derived 2-acyl-lysophosphatidylcholine and plasma free AA are two important sources of AA for extrahepatic tissues which exhibit a low rate of uptake of lipoprotein AA. Desaturation-elongation of LA to produce AA occurs both in liver and in extrahepatic tissues, plasma free LA being an important substrate particularly during fasting. The AA preference of the reacylation and transacylation reactions is crucial for the selective retention of AA in phospholipids.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acylation, Animals, Arachidonic Acid/administration & dosage, Biological Transport, Blood Platelets/metabolism, Central Nervous System/metabolism, Diet, Esterification, Fatty Acids/administration & dosage, Humans, Intestinal Absorption, Intestinal Mucosa/metabolism, Lipoproteins/metabolism, Liver/metabolism
in
Journal of Lipid Research
volume
42
issue
10
pages
1521 - 1542
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • scopus:0034759434
ISSN
0022-2275
language
English
LU publication?
yes
id
8bf6555f-1bd2-44b2-b5e9-1f4e27f49c70
alternative location
http://www.jlr.org/content/42/10/1521.long
date added to LUP
2019-05-23 19:09:42
date last changed
2019-08-16 14:24:33
@article{8bf6555f-1bd2-44b2-b5e9-1f4e27f49c70,
  abstract     = {<p>Tissue arachidonic acid (AA) pools originate from the diet, and from hepatic and extrahepatic desaturation-elongation of dietary linoleic acid (LA). This review summarizes the roles of absorption, transport, and formation of AA in the buildup of tissue AA pools. In humans who ingest 0.2-0.3 g of AA and 10-20 g of LA per day on a Western diet, the formation of AA from LA exceeds the dietary supply of AA. A number of factors favor the partitioning of AA to tissue phospholipids rather than adipose tissue and plasma triglycerides. The characteristics of AA transport with lipoproteins are discussed with focus on the role of lipoprotein lipase, lecithin:cholesterol acyltransferase, hepatic lipase, and the scavenger receptor BI and LDL receptors in tissue uptake of AA. Liver-derived 2-acyl-lysophosphatidylcholine and plasma free AA are two important sources of AA for extrahepatic tissues which exhibit a low rate of uptake of lipoprotein AA. Desaturation-elongation of LA to produce AA occurs both in liver and in extrahepatic tissues, plasma free LA being an important substrate particularly during fasting. The AA preference of the reacylation and transacylation reactions is crucial for the selective retention of AA in phospholipids.</p>},
  author       = {Zhou, L and Nilsson, Åke},
  issn         = {0022-2275},
  keyword      = {Acylation,Animals,Arachidonic Acid/administration & dosage,Biological Transport,Blood Platelets/metabolism,Central Nervous System/metabolism,Diet,Esterification,Fatty Acids/administration & dosage,Humans,Intestinal Absorption,Intestinal Mucosa/metabolism,Lipoproteins/metabolism,Liver/metabolism},
  language     = {eng},
  number       = {10},
  pages        = {1521--1542},
  publisher    = {American Society for Biochemistry and Molecular Biology},
  series       = {Journal of Lipid Research},
  title        = {Sources of eicosanoid precursor fatty acid pools in tissues},
  volume       = {42},
  year         = {2001},
}