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Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis

van der Voet, Jan A. ; Wesselius, Daan ; Zhang, Fan LU ; Vroegindeweij, Dammis ; Oei, Edwin H. ; Bierma-Zeinstra, Sita M.A. ; Englund, Martin LU orcid and Runhaar, Jos (2021) In Rheumatology (Oxford, England) 60(11). p.5175-5184
Abstract

OBJECTIVES: To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention. METHODS: In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the absolute change in medial and lateral extrusion (mm) and relative change in extrusion (%). Based upon literature, 11 factors were hypothesized to be associated with longitudinal change. Generalized estimating equations were used to model the effect on meniscal change (P <0.05). RESULTS: In total, 677... (More)

OBJECTIVES: To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention. METHODS: In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the absolute change in medial and lateral extrusion (mm) and relative change in extrusion (%). Based upon literature, 11 factors were hypothesized to be associated with longitudinal change. Generalized estimating equations were used to model the effect on meniscal change (P <0.05). RESULTS: In total, 677 knees of 343 women were available for analysis, with a mean age of 55.7 years (+/-3.2) and a mean BMI of 32.3 kg/m2 (+/-4.2). The greatest change in meniscal extrusion appeared medially with incident meniscal tear (4.4%; absolute 0.9 mm (95% CI: 0.3, 1.5; P =0.004); relative 14.5% (4.4, 24.7; 0.005)). Varus malalignment was associated with an increase of medial extrusion of 0.6 mm (37.6%; 0.1, 1.0; 0.009). A 5 kg/m2 higher baseline BMI was associated with absolute and relative increase of medial extrusion of 0.2 mm and 2.96% (0.1, 0.3; <0.001 and 1.3, 4.8; 0.002). Less explicit but significant changes in extrusion appeared with longitudinal change in BMI. CONCLUSION: Meniscal tears, varus malalignment and BMI were significantly associated with change in meniscal extrusion in middle-aged overweight women, providing viable therapeutic targets to prevent or reduce extrusion and thereby decelerate KOA development.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
extrusion, knee osteoarthritis, meniscus, MRI, obese, overweight
in
Rheumatology (Oxford, England)
volume
60
issue
11
pages
10 pages
publisher
Oxford University Press
external identifiers
  • pmid:33693533
  • scopus:85121941003
ISSN
1462-0332
DOI
10.1093/rheumatology/keab228
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
id
8bf8d559-b394-4ce3-a6d7-15b286106def
date added to LUP
2022-02-21 11:16:28
date last changed
2024-06-13 10:49:19
@article{8bf8d559-b394-4ce3-a6d7-15b286106def,
  abstract     = {{<p>OBJECTIVES: To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention. METHODS: In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the absolute change in medial and lateral extrusion (mm) and relative change in extrusion (%). Based upon literature, 11 factors were hypothesized to be associated with longitudinal change. Generalized estimating equations were used to model the effect on meniscal change (P &lt;0.05). RESULTS: In total, 677 knees of 343 women were available for analysis, with a mean age of 55.7 years (+/-3.2) and a mean BMI of 32.3 kg/m2 (+/-4.2). The greatest change in meniscal extrusion appeared medially with incident meniscal tear (4.4%; absolute 0.9 mm (95% CI: 0.3, 1.5; P =0.004); relative 14.5% (4.4, 24.7; 0.005)). Varus malalignment was associated with an increase of medial extrusion of 0.6 mm (37.6%; 0.1, 1.0; 0.009). A 5 kg/m2 higher baseline BMI was associated with absolute and relative increase of medial extrusion of 0.2 mm and 2.96% (0.1, 0.3; &lt;0.001 and 1.3, 4.8; 0.002). Less explicit but significant changes in extrusion appeared with longitudinal change in BMI. CONCLUSION: Meniscal tears, varus malalignment and BMI were significantly associated with change in meniscal extrusion in middle-aged overweight women, providing viable therapeutic targets to prevent or reduce extrusion and thereby decelerate KOA development.</p>}},
  author       = {{van der Voet, Jan A. and Wesselius, Daan and Zhang, Fan and Vroegindeweij, Dammis and Oei, Edwin H. and Bierma-Zeinstra, Sita M.A. and Englund, Martin and Runhaar, Jos}},
  issn         = {{1462-0332}},
  keywords     = {{extrusion; knee osteoarthritis; meniscus; MRI; obese; overweight}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  pages        = {{5175--5184}},
  publisher    = {{Oxford University Press}},
  series       = {{Rheumatology (Oxford, England)}},
  title        = {{Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis}},
  url          = {{http://dx.doi.org/10.1093/rheumatology/keab228}},
  doi          = {{10.1093/rheumatology/keab228}},
  volume       = {{60}},
  year         = {{2021}},
}