Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis
(2021) In Rheumatology (Oxford, England) 60(11). p.5175-5184- Abstract
OBJECTIVES: To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention. METHODS: In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the absolute change in medial and lateral extrusion (mm) and relative change in extrusion (%). Based upon literature, 11 factors were hypothesized to be associated with longitudinal change. Generalized estimating equations were used to model the effect on meniscal change (P <0.05). RESULTS: In total, 677... (More)
OBJECTIVES: To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention. METHODS: In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the absolute change in medial and lateral extrusion (mm) and relative change in extrusion (%). Based upon literature, 11 factors were hypothesized to be associated with longitudinal change. Generalized estimating equations were used to model the effect on meniscal change (P <0.05). RESULTS: In total, 677 knees of 343 women were available for analysis, with a mean age of 55.7 years (+/-3.2) and a mean BMI of 32.3 kg/m2 (+/-4.2). The greatest change in meniscal extrusion appeared medially with incident meniscal tear (4.4%; absolute 0.9 mm (95% CI: 0.3, 1.5; P =0.004); relative 14.5% (4.4, 24.7; 0.005)). Varus malalignment was associated with an increase of medial extrusion of 0.6 mm (37.6%; 0.1, 1.0; 0.009). A 5 kg/m2 higher baseline BMI was associated with absolute and relative increase of medial extrusion of 0.2 mm and 2.96% (0.1, 0.3; <0.001 and 1.3, 4.8; 0.002). Less explicit but significant changes in extrusion appeared with longitudinal change in BMI. CONCLUSION: Meniscal tears, varus malalignment and BMI were significantly associated with change in meniscal extrusion in middle-aged overweight women, providing viable therapeutic targets to prevent or reduce extrusion and thereby decelerate KOA development.
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- author
- van der Voet, Jan A. ; Wesselius, Daan ; Zhang, Fan LU ; Vroegindeweij, Dammis ; Oei, Edwin H. ; Bierma-Zeinstra, Sita M.A. ; Englund, Martin LU and Runhaar, Jos
- organization
- publishing date
- 2021-11-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- extrusion, knee osteoarthritis, meniscus, MRI, obese, overweight
- in
- Rheumatology (Oxford, England)
- volume
- 60
- issue
- 11
- pages
- 10 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:33693533
- scopus:85121941003
- ISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/keab228
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
- id
- 8bf8d559-b394-4ce3-a6d7-15b286106def
- date added to LUP
- 2022-02-21 11:16:28
- date last changed
- 2024-09-19 20:02:01
@article{8bf8d559-b394-4ce3-a6d7-15b286106def, abstract = {{<p>OBJECTIVES: To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention. METHODS: In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the absolute change in medial and lateral extrusion (mm) and relative change in extrusion (%). Based upon literature, 11 factors were hypothesized to be associated with longitudinal change. Generalized estimating equations were used to model the effect on meniscal change (P <0.05). RESULTS: In total, 677 knees of 343 women were available for analysis, with a mean age of 55.7 years (+/-3.2) and a mean BMI of 32.3 kg/m2 (+/-4.2). The greatest change in meniscal extrusion appeared medially with incident meniscal tear (4.4%; absolute 0.9 mm (95% CI: 0.3, 1.5; P =0.004); relative 14.5% (4.4, 24.7; 0.005)). Varus malalignment was associated with an increase of medial extrusion of 0.6 mm (37.6%; 0.1, 1.0; 0.009). A 5 kg/m2 higher baseline BMI was associated with absolute and relative increase of medial extrusion of 0.2 mm and 2.96% (0.1, 0.3; <0.001 and 1.3, 4.8; 0.002). Less explicit but significant changes in extrusion appeared with longitudinal change in BMI. CONCLUSION: Meniscal tears, varus malalignment and BMI were significantly associated with change in meniscal extrusion in middle-aged overweight women, providing viable therapeutic targets to prevent or reduce extrusion and thereby decelerate KOA development.</p>}}, author = {{van der Voet, Jan A. and Wesselius, Daan and Zhang, Fan and Vroegindeweij, Dammis and Oei, Edwin H. and Bierma-Zeinstra, Sita M.A. and Englund, Martin and Runhaar, Jos}}, issn = {{1462-0332}}, keywords = {{extrusion; knee osteoarthritis; meniscus; MRI; obese; overweight}}, language = {{eng}}, month = {{11}}, number = {{11}}, pages = {{5175--5184}}, publisher = {{Oxford University Press}}, series = {{Rheumatology (Oxford, England)}}, title = {{Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis}}, url = {{http://dx.doi.org/10.1093/rheumatology/keab228}}, doi = {{10.1093/rheumatology/keab228}}, volume = {{60}}, year = {{2021}}, }