Renal dysfunction after total knee replacement is not aggravated by bone cement
Nergelius, G. LU ; Lidgren, L. LU ; Grubb, A. LU
and Vinge, E.
LU
(1998)
In Acta Anaesthesiologica Scandinavica
42(8).
p.974-981
- Abstract
Background: Total knee replacement (TKR) has been associated with postoperative renal dysfunction. The use of monomeric methylmethacrylate (MMA) bone cement causes hypotension by several mechanisms. Methods: In 30 patients undergoing TKR with (n=16), or without (n=14) bone cement, serum levels of creatinine, cystatin C and creatine kinase (CK) and urinary levels of creatinine and markers for glomerular (albumin, IgG) and tubular (protein HC) function were recorded preoperatively and on days 1, 2, 4 and 8 postoperatively. Results: There were no changes in serum creatinine. Both groups had a transient, 5-fold rise in CK and a continuous increase in cystatin C. The urinary concentration of proteins increased postoperatively with a peak in... (More)
Background: Total knee replacement (TKR) has been associated with postoperative renal dysfunction. The use of monomeric methylmethacrylate (MMA) bone cement causes hypotension by several mechanisms. Methods: In 30 patients undergoing TKR with (n=16), or without (n=14) bone cement, serum levels of creatinine, cystatin C and creatine kinase (CK) and urinary levels of creatinine and markers for glomerular (albumin, IgG) and tubular (protein HC) function were recorded preoperatively and on days 1, 2, 4 and 8 postoperatively. Results: There were no changes in serum creatinine. Both groups had a transient, 5-fold rise in CK and a continuous increase in cystatin C. The urinary concentration of proteins increased postoperatively with a peak in the glomerular markers on day 1 and in the tubular marker on day 2. There were no significant differences in proteinuria between the groups. The 95% CIs for the difference in the means of the AUCs of the logarithmically transformed values for the proteins were never more than 19%. On day 8 all proteins had returned to their preoperative levels. Conclusion: Postoperatively, there was a transient increased leakage of proteins, indicating glomerular and tubular dysfunction; This was not influenced by the use of MMA bone cement.
(Less)
- author
- Nergelius, G.
LU
; Lidgren, L.
LU
; Grubb, A.
LU
and Vinge, E.
LU
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- keywords
- Cystatin C, Knee arthroplasty, Methylmethacrylate, Proteinuria: glomerular, tubular
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 42
- issue
- 8
- pages
- 974 - 981
- publisher
- Blackwell Munksgaard
- external identifiers
-
- scopus:0031669805
- pmid:9773143
- ISSN
- 0001-5172
- DOI
- 10.1111/j.1399-6576.1998.tb05358.x
- language
- English
- LU publication?
- no
- id
- 8c035463-9e6a-4344-bfd4-632b2acf34cb
- date added to LUP
- 2021-11-02 08:06:39
- date last changed
- 2025-10-14 11:30:05
@article{8c035463-9e6a-4344-bfd4-632b2acf34cb,
abstract = {{<p>Background: Total knee replacement (TKR) has been associated with postoperative renal dysfunction. The use of monomeric methylmethacrylate (MMA) bone cement causes hypotension by several mechanisms. Methods: In 30 patients undergoing TKR with (n=16), or without (n=14) bone cement, serum levels of creatinine, cystatin C and creatine kinase (CK) and urinary levels of creatinine and markers for glomerular (albumin, IgG) and tubular (protein HC) function were recorded preoperatively and on days 1, 2, 4 and 8 postoperatively. Results: There were no changes in serum creatinine. Both groups had a transient, 5-fold rise in CK and a continuous increase in cystatin C. The urinary concentration of proteins increased postoperatively with a peak in the glomerular markers on day 1 and in the tubular marker on day 2. There were no significant differences in proteinuria between the groups. The 95% CIs for the difference in the means of the AUCs of the logarithmically transformed values for the proteins were never more than 19%. On day 8 all proteins had returned to their preoperative levels. Conclusion: Postoperatively, there was a transient increased leakage of proteins, indicating glomerular and tubular dysfunction; This was not influenced by the use of MMA bone cement.</p>}},
author = {{Nergelius, G. and Lidgren, L. and Grubb, A. and Vinge, E.}},
issn = {{0001-5172}},
keywords = {{Cystatin C; Knee arthroplasty; Methylmethacrylate; Proteinuria: glomerular, tubular}},
language = {{eng}},
number = {{8}},
pages = {{974--981}},
publisher = {{Blackwell Munksgaard}},
series = {{Acta Anaesthesiologica Scandinavica}},
title = {{Renal dysfunction after total knee replacement is not aggravated by bone cement}},
url = {{http://dx.doi.org/10.1111/j.1399-6576.1998.tb05358.x}},
doi = {{10.1111/j.1399-6576.1998.tb05358.x}},
volume = {{42}},
year = {{1998}},
}