Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4+ CDw29- CD45R- p80- human T lymphocytes.
(1989) In Immunology 66(1). p.49-53- Abstract
- Functionally distinct subsets within the T-helper (CD4+) cell population have been described in man, rat and mouse. We have shown previously that the CD4+ 45R- human lymphocytes are producers of IL-2 within 24 hr of polyclonal stimulation and are the major interferon (IFN) producers. The mAbs 4B4 (CDw29) and Leu 8 (p80) are here used together with Leu-18 (CD45R) to characterize the subpopulations of the CD4+ human lymphocytes in more detail. The majority of the CD45R+ cells were CDw29- and the majority of the CDw29+ cells were CD45R-. Most of the CD45R+ cells (78%) were also p80+. A significant number of cells (12%) were CDw29- CD45R-. The predominant subpopulations were defined to be CDw29- CD45R+ p80+ (31%), CDw29+ CD45R- p80- (24%) and... (More)
- Functionally distinct subsets within the T-helper (CD4+) cell population have been described in man, rat and mouse. We have shown previously that the CD4+ 45R- human lymphocytes are producers of IL-2 within 24 hr of polyclonal stimulation and are the major interferon (IFN) producers. The mAbs 4B4 (CDw29) and Leu 8 (p80) are here used together with Leu-18 (CD45R) to characterize the subpopulations of the CD4+ human lymphocytes in more detail. The majority of the CD45R+ cells were CDw29- and the majority of the CDw29+ cells were CD45R-. Most of the CD45R+ cells (78%) were also p80+. A significant number of cells (12%) were CDw29- CD45R-. The predominant subpopulations were defined to be CDw29- CD45R+ p80+ (31%), CDw29+ CD45R- p80- (24%) and CDW29+ CD45R- p80+ (18%). Within the CD4+ CD45R- subpopulation different subsets vary in their capacities to produce IFN and to produce IL-2 within 24 hr after activation. CD4+ CDw29- CD45R- p80- T lymphocytes produced the largest quantities of IFN and IL-2. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/129770
- author
- Hedlund, G ; Dohlsten, M ; Sjögren, Hans Olof LU and Carlsson, R
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunology
- volume
- 66
- issue
- 1
- pages
- 49 - 53
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0024498078
- ISSN
- 0019-2805
- language
- English
- LU publication?
- yes
- id
- 8c2c96a7-7f3e-44e0-b322-f18554c49d72 (old id 129770)
- alternative location
- http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1385119
- date added to LUP
- 2016-04-01 12:32:36
- date last changed
- 2021-01-03 05:38:46
@article{8c2c96a7-7f3e-44e0-b322-f18554c49d72, abstract = {{Functionally distinct subsets within the T-helper (CD4+) cell population have been described in man, rat and mouse. We have shown previously that the CD4+ 45R- human lymphocytes are producers of IL-2 within 24 hr of polyclonal stimulation and are the major interferon (IFN) producers. The mAbs 4B4 (CDw29) and Leu 8 (p80) are here used together with Leu-18 (CD45R) to characterize the subpopulations of the CD4+ human lymphocytes in more detail. The majority of the CD45R+ cells were CDw29- and the majority of the CDw29+ cells were CD45R-. Most of the CD45R+ cells (78%) were also p80+. A significant number of cells (12%) were CDw29- CD45R-. The predominant subpopulations were defined to be CDw29- CD45R+ p80+ (31%), CDw29+ CD45R- p80- (24%) and CDW29+ CD45R- p80+ (18%). Within the CD4+ CD45R- subpopulation different subsets vary in their capacities to produce IFN and to produce IL-2 within 24 hr after activation. CD4+ CDw29- CD45R- p80- T lymphocytes produced the largest quantities of IFN and IL-2.}}, author = {{Hedlund, G and Dohlsten, M and Sjögren, Hans Olof and Carlsson, R}}, issn = {{0019-2805}}, language = {{eng}}, number = {{1}}, pages = {{49--53}}, publisher = {{Wiley-Blackwell}}, series = {{Immunology}}, title = {{Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4+ CDw29- CD45R- p80- human T lymphocytes.}}, url = {{http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1385119}}, volume = {{66}}, year = {{1989}}, }