Health-Related Quality of Life of Breast Cancer Patients in Iran: Pooled Analysis using Generalized Estimating Equations.
Ahmad Kiadaliri, Aliasghar LU
; Bastani, Peivand
and Ibrahimipour, Hossein
(2012)
In Asian Pacific Journal of Cancer Prevention
13(3).
p.941-944
- Abstract
- Objective:
The aim of current study was to evaluate the changes of health-related quality of life (HRQoL) and its clinical, demographic and socioeconomic determinants during chemotherapy and 4 months follow-up in women with breast cancer using a repeated measures framework.
Methods and Materials:
A double blind cohort study was performed in 100 breast cancer patients given fluorouracil, doxorubicin and cyclophosphamide (FAC) or docetaxel, doxorubicin, cyclophosphamide (TAC) in south of Iran. HRQoL was assessed at baseline, end of chemotherapy and four months thereafter using the QLQ-C30 questionnaire from European Organization for Research and Treatment of Cancer (EORTC). Generalized estimating... (More) - Objective:
The aim of current study was to evaluate the changes of health-related quality of life (HRQoL) and its clinical, demographic and socioeconomic determinants during chemotherapy and 4 months follow-up in women with breast cancer using a repeated measures framework.
Methods and Materials:
A double blind cohort study was performed in 100 breast cancer patients given fluorouracil, doxorubicin and cyclophosphamide (FAC) or docetaxel, doxorubicin, cyclophosphamide (TAC) in south of Iran. HRQoL was assessed at baseline, end of chemotherapy and four months thereafter using the QLQ-C30 questionnaire from European Organization for Research and Treatment of Cancer (EORTC). Generalized estimating equations (GEE) was applied for statistical analysis.
Results:
The mean of age at baseline was 48.5∓ 10.6. 70% and 14% of patients were married and smokers, respectively, and 20% suffered from another disease besides breast cancer. The results of GEE showed that after control for baseline scores, the HRQoL significantly improved over time. Although, the patients in FAC group had higher scores than the TAC group, the differences also diminished over time. Smoking, marital status and having child affected some scales of HRQoL. None of other variables were significantly related to HRQoL.
Conclusion:
Although patients in TAC groups had lower level of HRQoL over 8 months follow up, they experienced faster improvement than the FAC group. This implies that in long-term, improvements in TAC group are higher than FAC. Having children was positively correlated with HRQoL. Generally, there were no demographic and socio-economic differences in HRQoL in these patients between the chemotherapeutic regimens. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2608445
- author
- Ahmad Kiadaliri, Aliasghar
LU
; Bastani, Peivand
and Ibrahimipour, Hossein
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Asian Pacific Journal of Cancer Prevention
- volume
- 13
- issue
- 3
- pages
- 941 - 944
- publisher
- Asian Pacific Association for Cancer Education
- external identifiers
-
- pmid:22631676
- wos:000306182600035
- scopus:84871857716
- ISSN
- 1513-7368
- DOI
- 10.7314/APJCP.2012.13.3.941
- language
- English
- LU publication?
- yes
- id
- 8c52725b-a23d-4936-9cf8-6c3b7dcaea0e (old id 2608445)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22631676?dopt=Abstract
- date added to LUP
- 2016-04-04 09:42:43
- date last changed
- 2022-01-29 19:10:27
@article{8c52725b-a23d-4936-9cf8-6c3b7dcaea0e,
abstract = {{Objective: <br/><br>
The aim of current study was to evaluate the changes of health-related quality of life (HRQoL) and its clinical, demographic and socioeconomic determinants during chemotherapy and 4 months follow-up in women with breast cancer using a repeated measures framework. <br/><br>
<br/><br>
Methods and Materials: <br/><br>
A double blind cohort study was performed in 100 breast cancer patients given fluorouracil, doxorubicin and cyclophosphamide (FAC) or docetaxel, doxorubicin, cyclophosphamide (TAC) in south of Iran. HRQoL was assessed at baseline, end of chemotherapy and four months thereafter using the QLQ-C30 questionnaire from European Organization for Research and Treatment of Cancer (EORTC). Generalized estimating equations (GEE) was applied for statistical analysis. <br/><br>
<br/><br>
Results: <br/><br>
The mean of age at baseline was 48.5∓ 10.6. 70% and 14% of patients were married and smokers, respectively, and 20% suffered from another disease besides breast cancer. The results of GEE showed that after control for baseline scores, the HRQoL significantly improved over time. Although, the patients in FAC group had higher scores than the TAC group, the differences also diminished over time. Smoking, marital status and having child affected some scales of HRQoL. None of other variables were significantly related to HRQoL. <br/><br>
<br/><br>
Conclusion: <br/><br>
Although patients in TAC groups had lower level of HRQoL over 8 months follow up, they experienced faster improvement than the FAC group. This implies that in long-term, improvements in TAC group are higher than FAC. Having children was positively correlated with HRQoL. Generally, there were no demographic and socio-economic differences in HRQoL in these patients between the chemotherapeutic regimens.}},
author = {{Ahmad Kiadaliri, Aliasghar and Bastani, Peivand and Ibrahimipour, Hossein}},
issn = {{1513-7368}},
language = {{eng}},
number = {{3}},
pages = {{941--944}},
publisher = {{Asian Pacific Association for Cancer Education}},
series = {{Asian Pacific Journal of Cancer Prevention}},
title = {{Health-Related Quality of Life of Breast Cancer Patients in Iran: Pooled Analysis using Generalized Estimating Equations.}},
url = {{http://dx.doi.org/10.7314/APJCP.2012.13.3.941}},
doi = {{10.7314/APJCP.2012.13.3.941}},
volume = {{13}},
year = {{2012}},
}