Advanced

Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

Landegren, Nils; Rosen, Lindsey B.; Freyhult, Eva; Eriksson, Daniel; Fall, Tove LU ; Smith, Gustav LU ; Ferre, Elise M.N.; Brodin, Petter; Sharon, Donald and Snyder, Michael, et al. (2019) In eLife 8.
Abstract

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

Please use this url to cite or link to this publication:
@article{8c5df12c-1262-404a-95f4-304007b5d2ee,
  abstract     = {<p>The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.</p>},
  author       = {Landegren, Nils and Rosen, Lindsey B. and Freyhult, Eva and Eriksson, Daniel and Fall, Tove and Smith, Gustav and Ferre, Elise M.N. and Brodin, Petter and Sharon, Donald and Snyder, Michael and Lionakis, Michail and Anderson, Mark and Kämpe, Olle},
  issn         = {2050-084X},
  keyword      = {APS1/APECED,autoantibody,autoantigen,human,human biology,immune tolerance,immunology,inflammation,medicine,type 1 diabetes},
  language     = {eng},
  month        = {06},
  publisher    = {eLife Sciences Publications LTD.},
  series       = {eLife},
  title        = {Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'},
  url          = {http://dx.doi.org/10.7554/eLife.43578},
  volume       = {8},
  year         = {2019},
}