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Photoconjugation of Molecularly Imprinted Polymer with Magnetic Nanoparticles.

Xu, Changgang LU ; Uddin, Khan Mohammad Ahsan ; Shen, Xiantao LU ; Surangi, H ; Jayawardena, N ; Yan, Mingdi and Ye, Lei LU orcid (2013) In ACS Applied Materials and Interfaces 5(11). p.5208-5213
Abstract
Because of their synthetic accessibility, molecularly imprinted polymer (MIP) nanoparticles are ideal building blocks for preparing multifunctional composites. In this work, we developed a general photocoupling chemistry to enable simple conjugation of MIP nanoparticles with inorganic magnetic nanoparticles. We first synthesized MIP nanoparticles using propranolol as a model template and perfluorophenyl azide-modified silica-coated magnetic nanoparticles. Using a simple photoactivation followed by facile purification with a magnet, we obtained magnetic composite particles that showed selective uptake of propranolol. We characterized the nanoparticles and composite materials using FT-IR, TEM, fluorescence spectroscopy, and radioligand... (More)
Because of their synthetic accessibility, molecularly imprinted polymer (MIP) nanoparticles are ideal building blocks for preparing multifunctional composites. In this work, we developed a general photocoupling chemistry to enable simple conjugation of MIP nanoparticles with inorganic magnetic nanoparticles. We first synthesized MIP nanoparticles using propranolol as a model template and perfluorophenyl azide-modified silica-coated magnetic nanoparticles. Using a simple photoactivation followed by facile purification with a magnet, we obtained magnetic composite particles that showed selective uptake of propranolol. We characterized the nanoparticles and composite materials using FT-IR, TEM, fluorescence spectroscopy, and radioligand binding analysis. Through the high molecular selectivity of the magnetic composite, we demonstrated the nondestructive feature and the high efficiency of the photocoupling chemistry. The versatile photoconjugation method developed in this work should also be very useful for combining organic MIPs with other inorganic nanoparticles to enable new chemical sensors and high efficiency photocatalysts. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ACS Applied Materials and Interfaces
volume
5
issue
11
pages
5208 - 5213
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000320484000095
  • pmid:23673293
  • scopus:84879073008
  • pmid:23673293
ISSN
1944-8244
DOI
10.1021/am401042u
language
English
LU publication?
yes
id
8c68db67-86b5-49e2-b506-31076323917e (old id 3804419)
date added to LUP
2016-04-01 10:51:10
date last changed
2022-04-12 18:13:03
@article{8c68db67-86b5-49e2-b506-31076323917e,
  abstract     = {{Because of their synthetic accessibility, molecularly imprinted polymer (MIP) nanoparticles are ideal building blocks for preparing multifunctional composites. In this work, we developed a general photocoupling chemistry to enable simple conjugation of MIP nanoparticles with inorganic magnetic nanoparticles. We first synthesized MIP nanoparticles using propranolol as a model template and perfluorophenyl azide-modified silica-coated magnetic nanoparticles. Using a simple photoactivation followed by facile purification with a magnet, we obtained magnetic composite particles that showed selective uptake of propranolol. We characterized the nanoparticles and composite materials using FT-IR, TEM, fluorescence spectroscopy, and radioligand binding analysis. Through the high molecular selectivity of the magnetic composite, we demonstrated the nondestructive feature and the high efficiency of the photocoupling chemistry. The versatile photoconjugation method developed in this work should also be very useful for combining organic MIPs with other inorganic nanoparticles to enable new chemical sensors and high efficiency photocatalysts.}},
  author       = {{Xu, Changgang and Uddin, Khan Mohammad Ahsan and Shen, Xiantao and Surangi, H and Jayawardena, N and Yan, Mingdi and Ye, Lei}},
  issn         = {{1944-8244}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{5208--5213}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Applied Materials and Interfaces}},
  title        = {{Photoconjugation of Molecularly Imprinted Polymer with Magnetic Nanoparticles.}},
  url          = {{http://dx.doi.org/10.1021/am401042u}},
  doi          = {{10.1021/am401042u}},
  volume       = {{5}},
  year         = {{2013}},
}