Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

FILTRATION QUALITY: A NEW MEASURE OF RENAL DISEASE

Grubb, A. LU orcid ; Lindström, V. LU orcid ; Kristensen, K. ; Christensson, A. LU ; Wide-Swensson, D. LU ; Strevens, H. LU ; Schmidt, C. and Blirup-Jensen, S. (2007) In Clinical Chemistry and Laboratory Medicine 45(Suppl 1). p.273-274
Abstract
Background Although GFR is a good general indicator of renal disease, it will not detect those renal diseases in which the composition of the glomerular filtrate is deranged in the presence of a normal GFR. Markers for filtration quality were therefore sought.
Methods The plasma levels of GFR-markers of various sizes were determined in healthy pregnant females, in patients with preeclampsia or on hemodialysis and in a general patient population. The plasma clearance of iohexol was used for determination of GFR.
Results The plasma levels of creatinine (113 Da), beta-2-microglobulin (12 kDa), cystatin C (13 kDa), beta-trace protein (23-29 kDa) were determined not only by GFR but also by the size of the glomerular... (More)
Background Although GFR is a good general indicator of renal disease, it will not detect those renal diseases in which the composition of the glomerular filtrate is deranged in the presence of a normal GFR. Markers for filtration quality were therefore sought.
Methods The plasma levels of GFR-markers of various sizes were determined in healthy pregnant females, in patients with preeclampsia or on hemodialysis and in a general patient population. The plasma clearance of iohexol was used for determination of GFR.
Results The plasma levels of creatinine (113 Da), beta-2-microglobulin (12 kDa), cystatin C (13 kDa), beta-trace protein (23-29 kDa) were determined not only by GFR but also by the size of the glomerular basement pores in pregnant females with or without preeclampsia. Similarly, the changes in the plasma levels of these markers upon hemodialysis mirrored the pore sizes of the membranes used.
Conclusions Determination of plasma levels of GFR-markers of different sizes allows definition of a new parameter, tentatively called “filtration quality”, which can identify renal disease in the absence of reduced GFR as determined by the plasma clearance of low molecular mass injected substances e.g. iohexol, 51Cr-EDTA.
(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Clinical Chemistry and Laboratory Medicine
volume
45
issue
Suppl 1
article number
T195
pages
273 - 274
publisher
De Gruyter
ISSN
1434-6621
DOI
10.1515/CCLM.2007.223
language
English
LU publication?
no
id
8c9cb0b1-4c6f-480b-80c1-403cb671b869
date added to LUP
2021-11-08 17:59:12
date last changed
2021-11-09 13:41:24
@misc{8c9cb0b1-4c6f-480b-80c1-403cb671b869,
  abstract     = {{<b>Background</b> Although GFR is a good general indicator of renal disease, it will not detect those renal diseases in which the composition of the glomerular filtrate is deranged in the presence of a normal GFR. Markers for filtration quality were therefore sought.<br/><b>Methods</b> The plasma levels of GFR-markers of various sizes were determined in healthy pregnant females, in patients with preeclampsia or on hemodialysis and in a general patient population. The plasma clearance of iohexol was used for determination of GFR.<br/><b>Results</b> The plasma levels of creatinine (113 Da), beta-2-microglobulin (12 kDa), cystatin C (13 kDa), beta-trace protein (23-29 kDa) were determined not only by GFR but also by the size of the glomerular basement pores in pregnant females with or without preeclampsia. Similarly, the changes in the plasma levels of these markers upon hemodialysis mirrored the pore sizes of the membranes used.<br/><b>Conclusions</b> Determination of plasma levels of GFR-markers of different sizes allows definition of a new parameter, tentatively called “filtration quality”, which can identify renal disease in the absence of reduced GFR as determined by the plasma clearance of low molecular mass injected substances e.g. iohexol, 51Cr-EDTA.<br/>}},
  author       = {{Grubb, A. and Lindström, V. and Kristensen, K. and Christensson, A. and Wide-Swensson, D. and Strevens, H. and Schmidt, C. and Blirup-Jensen, S.}},
  issn         = {{1434-6621}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{Suppl 1}},
  pages        = {{273--274}},
  publisher    = {{De Gruyter}},
  series       = {{Clinical Chemistry and Laboratory Medicine}},
  title        = {{FILTRATION QUALITY: A NEW MEASURE OF RENAL DISEASE}},
  url          = {{http://dx.doi.org/10.1515/CCLM.2007.223}},
  doi          = {{10.1515/CCLM.2007.223}},
  volume       = {{45}},
  year         = {{2007}},
}