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Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery

Wiberg-itzel, Eva ; Josephson, Hampus ; Wiberg, Nana ; Olson, Linus ; Winbladh, Birger and Karlsson, Mathias (2015) In Journal of Neonatal Biology 4(4).
Abstract
Background:
LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns.
Method:
a prospective observational study was performed at Soder Hospital, Stockholm, Sweden during 2011-2012. Umbilical cord blood was collected at delivery, and value of LDH was analysed in 549 healthy infants >37 weeks of gestation, born after an uncomplicated pregnancy from a healthy mother.
Results:
The 2.5th and 97.5th percentile for arterial LDH was 162-612 u/L and 252-636 u/L for venous LDH. Instrumental... (More)
Background:
LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns.
Method:
a prospective observational study was performed at Soder Hospital, Stockholm, Sweden during 2011-2012. Umbilical cord blood was collected at delivery, and value of LDH was analysed in 549 healthy infants >37 weeks of gestation, born after an uncomplicated pregnancy from a healthy mother.
Results:
The 2.5th and 97.5th percentile for arterial LDH was 162-612 u/L and 252-636 u/L for venous LDH. Instrumental delivery and acute caesarian section showed significantly higher intervals and elective caesarian section significantly lower than vaginal delivery. Haemolysis (>0.3 g/l) disqualified a 13-41% of the samples.
Conclusion:
Reported LDH levels are in accordance with earlier studies and appear to be a sensitive marker for intrapartal stress factors. The absence of an arterial/venous difference makes the sampling of cord blood easier but frequent haemolysis is a problem when using the standard method of analyses. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neonatal Biology
volume
4
issue
4
publisher
Walsh Medical Media
ISSN
2167-0897
DOI
10.4172/2167-0897.1000204
language
English
LU publication?
no
id
8ce628ec-cd94-4a1f-a3d9-567f68fe0794
date added to LUP
2019-06-12 12:22:40
date last changed
2019-06-12 14:54:18
@article{8ce628ec-cd94-4a1f-a3d9-567f68fe0794,
  abstract     = {{Background:<br>
LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns.<br>
Method:<br>
a prospective observational study was performed at Soder Hospital, Stockholm,  Sweden during 2011-2012. Umbilical cord blood was collected at delivery, and value of LDH was analysed in 549 healthy infants &gt;37 weeks of gestation, born after an uncomplicated pregnancy from a healthy mother.<br>
Results:<br>
The 2.5th and 97.5th percentile for arterial LDH was 162-612 u/L and 252-636  u/L for venous LDH. Instrumental delivery and acute caesarian section showed significantly higher intervals and elective caesarian section significantly lower than vaginal delivery. Haemolysis (&gt;0.3 g/l) disqualified a 13-41% of the samples.<br>
Conclusion:<br>
Reported LDH levels are in accordance with earlier studies and appear to be a sensitive marker for intrapartal stress factors. The  absence of an arterial/venous difference makes  the sampling of cord blood easier but frequent haemolysis is a problem when using the standard method of analyses.}},
  author       = {{Wiberg-itzel, Eva and Josephson, Hampus and Wiberg, Nana and Olson, Linus and Winbladh, Birger and Karlsson, Mathias}},
  issn         = {{2167-0897}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Walsh Medical Media}},
  series       = {{Journal of Neonatal Biology}},
  title        = {{Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery}},
  url          = {{http://dx.doi.org/10.4172/2167-0897.1000204}},
  doi          = {{10.4172/2167-0897.1000204}},
  volume       = {{4}},
  year         = {{2015}},
}