Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery
(2015) In Journal of Neonatal Biology 4(4).- Abstract
- Background:
LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns.
Method:
a prospective observational study was performed at Soder Hospital, Stockholm, Sweden during 2011-2012. Umbilical cord blood was collected at delivery, and value of LDH was analysed in 549 healthy infants >37 weeks of gestation, born after an uncomplicated pregnancy from a healthy mother.
Results:
The 2.5th and 97.5th percentile for arterial LDH was 162-612 u/L and 252-636 u/L for venous LDH. Instrumental... (More) - Background:
LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns.
Method:
a prospective observational study was performed at Soder Hospital, Stockholm, Sweden during 2011-2012. Umbilical cord blood was collected at delivery, and value of LDH was analysed in 549 healthy infants >37 weeks of gestation, born after an uncomplicated pregnancy from a healthy mother.
Results:
The 2.5th and 97.5th percentile for arterial LDH was 162-612 u/L and 252-636 u/L for venous LDH. Instrumental delivery and acute caesarian section showed significantly higher intervals and elective caesarian section significantly lower than vaginal delivery. Haemolysis (>0.3 g/l) disqualified a 13-41% of the samples.
Conclusion:
Reported LDH levels are in accordance with earlier studies and appear to be a sensitive marker for intrapartal stress factors. The absence of an arterial/venous difference makes the sampling of cord blood easier but frequent haemolysis is a problem when using the standard method of analyses. (Less)
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https://lup.lub.lu.se/record/8ce628ec-cd94-4a1f-a3d9-567f68fe0794
- author
- Wiberg-itzel, Eva ; Josephson, Hampus ; Wiberg, Nana ; Olson, Linus ; Winbladh, Birger and Karlsson, Mathias
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neonatal Biology
- volume
- 4
- issue
- 4
- publisher
- Walsh Medical Media
- ISSN
- 2167-0897
- DOI
- 10.4172/2167-0897.1000204
- language
- English
- LU publication?
- no
- id
- 8ce628ec-cd94-4a1f-a3d9-567f68fe0794
- date added to LUP
- 2019-06-12 12:22:40
- date last changed
- 2019-06-12 14:54:18
@article{8ce628ec-cd94-4a1f-a3d9-567f68fe0794, abstract = {{Background:<br> LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns.<br> Method:<br> a prospective observational study was performed at Soder Hospital, Stockholm, Sweden during 2011-2012. Umbilical cord blood was collected at delivery, and value of LDH was analysed in 549 healthy infants >37 weeks of gestation, born after an uncomplicated pregnancy from a healthy mother.<br> Results:<br> The 2.5th and 97.5th percentile for arterial LDH was 162-612 u/L and 252-636 u/L for venous LDH. Instrumental delivery and acute caesarian section showed significantly higher intervals and elective caesarian section significantly lower than vaginal delivery. Haemolysis (>0.3 g/l) disqualified a 13-41% of the samples.<br> Conclusion:<br> Reported LDH levels are in accordance with earlier studies and appear to be a sensitive marker for intrapartal stress factors. The absence of an arterial/venous difference makes the sampling of cord blood easier but frequent haemolysis is a problem when using the standard method of analyses.}}, author = {{Wiberg-itzel, Eva and Josephson, Hampus and Wiberg, Nana and Olson, Linus and Winbladh, Birger and Karlsson, Mathias}}, issn = {{2167-0897}}, language = {{eng}}, number = {{4}}, publisher = {{Walsh Medical Media}}, series = {{Journal of Neonatal Biology}}, title = {{Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery}}, url = {{http://dx.doi.org/10.4172/2167-0897.1000204}}, doi = {{10.4172/2167-0897.1000204}}, volume = {{4}}, year = {{2015}}, }