Value of preclinical systematic reviews and meta-analyses in pediatric research
Romantsik, Olga LU ; Bank, Matthias LU
; Menon, Julia M L
; Malhotra, Atul
and Bruschettini, Matteo
LU
(2024)
In Pediatric Research
p.1-11
- Abstract
Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the main goals of preclinical SRs is to identify aspiring treatment strategies and evaluate if currently available data is solid enough to translate to clinical trials or highlight the gaps, thus justifying the need for new studies. It is imperative to rigorously follow the methodological standards that are widely available. These include registration of the protocol and adherence to guidelines for assessing the risk of bias, study quality, and certainty of evidence. A special consideration... (More)
Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the main goals of preclinical SRs is to identify aspiring treatment strategies and evaluate if currently available data is solid enough to translate to clinical trials or highlight the gaps, thus justifying the need for new studies. It is imperative to rigorously follow the methodological standards that are widely available. These include registration of the protocol and adherence to guidelines for assessing the risk of bias, study quality, and certainty of evidence. A special consideration should be made for pediatric SRs, clinical and preclinical, due to the unique characteristics of this age group. These include rationale for intervention and comparison of primary and secondary outcomes. Outcomes measured should acknowledge age-related physiological changes and maturational processes of different organ systems. It is crucial to choose the age of the animals appropriately and its possible correspondence for specific pediatric age groups. The findings of well-conducted SRs of preclinical studies have the potential to provide a reliable evidence synthesis to guide the design of future preclinical and clinical studies. IMPACT: This narrative review highlights the importance of rigorous design, conduct and reporting of preclinical primary studies and systematic reviews. A special consideration should be made for pediatric systematic reviews of preclinical studies, due to the unique characteristics of this age group.
(Less)
- author
- Romantsik, Olga
LU
; Bank, Matthias
LU
; Menon, Julia M L
; Malhotra, Atul
and Bruschettini, Matteo
LU
- organization
- publishing date
- 2024-04-13
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Pediatric Research
- pages
- 1 - 11
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- scopus:85190132115
- pmid:38615075
- ISSN
- 1530-0447
- DOI
- 10.1038/s41390-024-03197-1
- language
- English
- LU publication?
- yes
- additional info
- © 2024. The Author(s).
- id
- 8cf9a22f-95b3-4122-91f2-7c53fad94b11
- date added to LUP
- 2024-04-15 11:54:33
- date last changed
- 2024-04-22 04:01:29
@article{8cf9a22f-95b3-4122-91f2-7c53fad94b11,
abstract = {{<p>Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the main goals of preclinical SRs is to identify aspiring treatment strategies and evaluate if currently available data is solid enough to translate to clinical trials or highlight the gaps, thus justifying the need for new studies. It is imperative to rigorously follow the methodological standards that are widely available. These include registration of the protocol and adherence to guidelines for assessing the risk of bias, study quality, and certainty of evidence. A special consideration should be made for pediatric SRs, clinical and preclinical, due to the unique characteristics of this age group. These include rationale for intervention and comparison of primary and secondary outcomes. Outcomes measured should acknowledge age-related physiological changes and maturational processes of different organ systems. It is crucial to choose the age of the animals appropriately and its possible correspondence for specific pediatric age groups. The findings of well-conducted SRs of preclinical studies have the potential to provide a reliable evidence synthesis to guide the design of future preclinical and clinical studies. IMPACT: This narrative review highlights the importance of rigorous design, conduct and reporting of preclinical primary studies and systematic reviews. A special consideration should be made for pediatric systematic reviews of preclinical studies, due to the unique characteristics of this age group.</p>}},
author = {{Romantsik, Olga and Bank, Matthias and Menon, Julia M L and Malhotra, Atul and Bruschettini, Matteo}},
issn = {{1530-0447}},
language = {{eng}},
month = {{04}},
pages = {{1--11}},
publisher = {{International Pediatric Foundation Inc.}},
series = {{Pediatric Research}},
title = {{Value of preclinical systematic reviews and meta-analyses in pediatric research}},
url = {{http://dx.doi.org/10.1038/s41390-024-03197-1}},
doi = {{10.1038/s41390-024-03197-1}},
year = {{2024}},
}