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Right heart structure, geometry and function assessed by echocardiography in 6-Year-old children born extremely preterm-a population-based cohort study

Mohlkert, Lilly Ann ; Hallberg, Jenny ; Broberg, Olof LU ; Sjöberg, Gunnar ; Rydberg, Annika ; Liuba, Petru LU ; Fellman, Vineta LU orcid ; Domellöf, Magnus ; Norman, Mikael and Halvorsen, Cecilia Pegelow (2021) In Journal of Clinical Medicine 10(1). p.1-17
Abstract

Preterm birth has been associated with altered cardiac phenotype in adults. Our aim was to test the hypothesis that children surviving extremely preterm birth have important structural or functional changes of the right heart or pulmonary circulation. We also examined relations between birth size, gestational age, neonatal diagnoses of bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA) with cardiac outcomes. We assessed a population-based cohort of children born in Sweden before 27 weeks of gestation with echocardiography at 6.5 years of age (n = 176). Each preterm child was matched to a healthy control child born at term. Children born preterm had significantly smaller right atria, right ventricles with smaller widths,... (More)

Preterm birth has been associated with altered cardiac phenotype in adults. Our aim was to test the hypothesis that children surviving extremely preterm birth have important structural or functional changes of the right heart or pulmonary circulation. We also examined relations between birth size, gestational age, neonatal diagnoses of bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA) with cardiac outcomes. We assessed a population-based cohort of children born in Sweden before 27 weeks of gestation with echocardiography at 6.5 years of age (n = 176). Each preterm child was matched to a healthy control child born at term. Children born preterm had significantly smaller right atria, right ventricles with smaller widths, higher relative wall thickness and higher estimated pulmonary vascular resistance (PVR) than controls. In preterm children, PVR and right ventricular myocardial performance index (RVmpi’) were significantly higher in those with a PDA as neonates than in those without PDA, but no such associations were found with BPD. In conclusion, children born extremely preterm exhibit higher estimated PVR, altered right heart structure and function compared with children born at term.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Echocardiography, Myocardial performance index, Patent ductus arteriosus, Preterm in- fant, Pulmonary arterial hypertension, Right atrium, Right ventricle
in
Journal of Clinical Medicine
volume
10
issue
1
article number
122
pages
17 pages
publisher
MDPI AG
external identifiers
  • scopus:85109337627
  • pmid:33396414
ISSN
2077-0383
DOI
10.3390/jcm10010122
language
English
LU publication?
yes
id
8d047352-0842-4020-b2e2-92007dd6e89c
date added to LUP
2022-03-22 17:22:47
date last changed
2024-06-21 03:39:22
@article{8d047352-0842-4020-b2e2-92007dd6e89c,
  abstract     = {{<p>Preterm birth has been associated with altered cardiac phenotype in adults. Our aim was to test the hypothesis that children surviving extremely preterm birth have important structural or functional changes of the right heart or pulmonary circulation. We also examined relations between birth size, gestational age, neonatal diagnoses of bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA) with cardiac outcomes. We assessed a population-based cohort of children born in Sweden before 27 weeks of gestation with echocardiography at 6.5 years of age (n = 176). Each preterm child was matched to a healthy control child born at term. Children born preterm had significantly smaller right atria, right ventricles with smaller widths, higher relative wall thickness and higher estimated pulmonary vascular resistance (PVR) than controls. In preterm children, PVR and right ventricular myocardial performance index (RVmpi’) were significantly higher in those with a PDA as neonates than in those without PDA, but no such associations were found with BPD. In conclusion, children born extremely preterm exhibit higher estimated PVR, altered right heart structure and function compared with children born at term.</p>}},
  author       = {{Mohlkert, Lilly Ann and Hallberg, Jenny and Broberg, Olof and Sjöberg, Gunnar and Rydberg, Annika and Liuba, Petru and Fellman, Vineta and Domellöf, Magnus and Norman, Mikael and Halvorsen, Cecilia Pegelow}},
  issn         = {{2077-0383}},
  keywords     = {{Echocardiography; Myocardial performance index; Patent ductus arteriosus; Preterm in- fant; Pulmonary arterial hypertension; Right atrium; Right ventricle}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{1--17}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Right heart structure, geometry and function assessed by echocardiography in 6-Year-old children born extremely preterm-a population-based cohort study}},
  url          = {{http://dx.doi.org/10.3390/jcm10010122}},
  doi          = {{10.3390/jcm10010122}},
  volume       = {{10}},
  year         = {{2021}},
}