Antiatherosclerotic effects of beta-blockers
(2003) In American Journal of Cardiology 91(12, Suppl. 1). p.25-29- Abstract
- Accumulating data from studies in animals and humans indicate that beta-blockade has antiatherosclerotic effects. To date, 2 long-term ultrasound studies provide the strongest evidence. The Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS) trial reported favorable effects with beta-blockade on early stages of atherosclerosis in patients with carotid plaque but no symptoms of carotid artery disease. Compared with placebo, metoprolol controlled release/extended release (CR/XL) 25 mg once daily significantly reduced plaque thickness after 18 months of treatment (net difference -0.058 mm/year; p <0.001) and at 3 years' follow-up (net difference -0.023 mm/year; p = 0.018). The Effects of Long-Term Treatment of Metoprolol... (More)
- Accumulating data from studies in animals and humans indicate that beta-blockade has antiatherosclerotic effects. To date, 2 long-term ultrasound studies provide the strongest evidence. The Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS) trial reported favorable effects with beta-blockade on early stages of atherosclerosis in patients with carotid plaque but no symptoms of carotid artery disease. Compared with placebo, metoprolol controlled release/extended release (CR/XL) 25 mg once daily significantly reduced plaque thickness after 18 months of treatment (net difference -0.058 mm/year; p <0.001) and at 3 years' follow-up (net difference -0.023 mm/year; p = 0.018). The Effects of Long-Term Treatment of Metoprolol CR/XL on Surrogate Variables for Atherosclerotic Disease (ELVA) trial demonstrated that β-blockers and statins affect different mechanisms in the atherosclerotic process and have additive beneficial effects. Patients with hypercholesterolemia were randomized to metoprolol CR/XL 100 mg once daily or placebo once daily and concomitant statin therapy. The metoprolol CR/XL group had a significantly lower rate of progression of the composite carotid bulb intima-media thickness (IMT) plus common carotid IMT than the placebo group, both at I year (-0.08 vs -0.01 mm; p = 0.004) and after 3 years' follow-up (-0.06 vs +0.03 mm; p = 0.011). Several factors may contribute to the mechanism of benefit in these trials, including reduced sympathetic activity, improved hemodynamic parameters, and direct effects on the vascular enclothelium. (C) 2003 by Excerpta Medica, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/308325
- author
- Wikstrand, J ; Berglund, Göran LU ; Hedblad, Bo LU and Hulthe, J
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Cardiology
- volume
- 91
- issue
- 12, Suppl. 1
- pages
- 25 - 29
- publisher
- Excerpta Medica
- external identifiers
-
- wos:000183772500005
- pmid:12818732
- scopus:0038344675
- ISSN
- 1879-1913
- DOI
- 10.1016/S0002-9149(03)00431-4
- language
- English
- LU publication?
- yes
- id
- 8d3c4add-fbf1-4f9a-b8f0-bb397b0a6c58 (old id 308325)
- date added to LUP
- 2016-04-01 12:03:49
- date last changed
- 2022-01-26 22:18:25
@article{8d3c4add-fbf1-4f9a-b8f0-bb397b0a6c58, abstract = {{Accumulating data from studies in animals and humans indicate that beta-blockade has antiatherosclerotic effects. To date, 2 long-term ultrasound studies provide the strongest evidence. The Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS) trial reported favorable effects with beta-blockade on early stages of atherosclerosis in patients with carotid plaque but no symptoms of carotid artery disease. Compared with placebo, metoprolol controlled release/extended release (CR/XL) 25 mg once daily significantly reduced plaque thickness after 18 months of treatment (net difference -0.058 mm/year; p <0.001) and at 3 years' follow-up (net difference -0.023 mm/year; p = 0.018). The Effects of Long-Term Treatment of Metoprolol CR/XL on Surrogate Variables for Atherosclerotic Disease (ELVA) trial demonstrated that β-blockers and statins affect different mechanisms in the atherosclerotic process and have additive beneficial effects. Patients with hypercholesterolemia were randomized to metoprolol CR/XL 100 mg once daily or placebo once daily and concomitant statin therapy. The metoprolol CR/XL group had a significantly lower rate of progression of the composite carotid bulb intima-media thickness (IMT) plus common carotid IMT than the placebo group, both at I year (-0.08 vs -0.01 mm; p = 0.004) and after 3 years' follow-up (-0.06 vs +0.03 mm; p = 0.011). Several factors may contribute to the mechanism of benefit in these trials, including reduced sympathetic activity, improved hemodynamic parameters, and direct effects on the vascular enclothelium. (C) 2003 by Excerpta Medica, Inc.}}, author = {{Wikstrand, J and Berglund, Göran and Hedblad, Bo and Hulthe, J}}, issn = {{1879-1913}}, language = {{eng}}, number = {{12, Suppl. 1}}, pages = {{25--29}}, publisher = {{Excerpta Medica}}, series = {{American Journal of Cardiology}}, title = {{Antiatherosclerotic effects of beta-blockers}}, url = {{http://dx.doi.org/10.1016/S0002-9149(03)00431-4}}, doi = {{10.1016/S0002-9149(03)00431-4}}, volume = {{91}}, year = {{2003}}, }