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Nonadherence to treatment causing acute hospitalizations in people with epilepsy : An observational, prospective study

Samsonsen, Christian ; Reimers, Arne LU ; Bråthen, Geir ; Helde, Grethe and Brodtkorb, Eylert (2014) In Epilepsia 55(11). p.125-128
Abstract

The aim was to assess the clinical relevance of antiepileptic drug (AED) nonadherence by means of therapeutic drug concentration monitoring (TDM). Two hundred eighty-two consecutive patients with epilepsy acutely admitted to hospital for seizures were included. Nonadherence was defined as having a serum concentration/dose ratio at admission of <75% of the patient's own control value (probable nonadherence: 50-75%; definite: < 50%). Nonadherence was identified in 39% of patients (definite 24%; probable 15%). It was significantly more common in patients with generalized seizures compared to those with focal onset seizures, and in patients <30 years compared to older patients. When specifically asked, 44% of nonadherent patients... (More)

The aim was to assess the clinical relevance of antiepileptic drug (AED) nonadherence by means of therapeutic drug concentration monitoring (TDM). Two hundred eighty-two consecutive patients with epilepsy acutely admitted to hospital for seizures were included. Nonadherence was defined as having a serum concentration/dose ratio at admission of <75% of the patient's own control value (probable nonadherence: 50-75%; definite: < 50%). Nonadherence was identified in 39% of patients (definite 24%; probable 15%). It was significantly more common in patients with generalized seizures compared to those with focal onset seizures, and in patients <30 years compared to older patients. When specifically asked, 44% of nonadherent patients claimed regular intake. Nonadherence is a major cause of seizure breakthrough in patients with epilepsy, particularly in young adults. Many patients seem to be unaware of missed drug intake. Prompt measurements of AED serum concentrations should be available as part of the emergency care for patients acutely hospitalized for seizures to permit this issue to be thoroughly addressed prior to discharge.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Adherence, Seizure, Therapeutic drug monitoring
in
Epilepsia
volume
55
issue
11
pages
125 - 128
publisher
Wiley-Blackwell
external identifiers
  • scopus:84912119425
  • pmid:25252007
ISSN
0013-9580
DOI
10.1111/epi.12801
language
English
LU publication?
no
additional info
Publisher Copyright: © 2014 International League Against Epilepsy.
id
8d62eed3-f28e-428e-a5c0-14724c54056b
date added to LUP
2024-08-31 14:47:32
date last changed
2024-09-02 08:25:37
@article{8d62eed3-f28e-428e-a5c0-14724c54056b,
  abstract     = {{<p>The aim was to assess the clinical relevance of antiepileptic drug (AED) nonadherence by means of therapeutic drug concentration monitoring (TDM). Two hundred eighty-two consecutive patients with epilepsy acutely admitted to hospital for seizures were included. Nonadherence was defined as having a serum concentration/dose ratio at admission of &lt;75% of the patient's own control value (probable nonadherence: 50-75%; definite: &lt; 50%). Nonadherence was identified in 39% of patients (definite 24%; probable 15%). It was significantly more common in patients with generalized seizures compared to those with focal onset seizures, and in patients &lt;30 years compared to older patients. When specifically asked, 44% of nonadherent patients claimed regular intake. Nonadherence is a major cause of seizure breakthrough in patients with epilepsy, particularly in young adults. Many patients seem to be unaware of missed drug intake. Prompt measurements of AED serum concentrations should be available as part of the emergency care for patients acutely hospitalized for seizures to permit this issue to be thoroughly addressed prior to discharge.</p>}},
  author       = {{Samsonsen, Christian and Reimers, Arne and Bråthen, Geir and Helde, Grethe and Brodtkorb, Eylert}},
  issn         = {{0013-9580}},
  keywords     = {{Adherence; Seizure; Therapeutic drug monitoring}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  pages        = {{125--128}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Epilepsia}},
  title        = {{Nonadherence to treatment causing acute hospitalizations in people with epilepsy : An observational, prospective study}},
  url          = {{http://dx.doi.org/10.1111/epi.12801}},
  doi          = {{10.1111/epi.12801}},
  volume       = {{55}},
  year         = {{2014}},
}