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Removal of APIs and bacteria from hospital wastewater by MBR plus O-3, O-3 + H2O2, PAC or ClO2

Nielsen, U. ; Hastrup, C. ; Klausen, M. M. ; Pedersen, B. M. ; Kristensen, G. H. ; la Cour Jansen, Jes LU ; Bak, S. N. and Tuerk, J. (2013) In Water Science and Technology 67(4). p.854-862
Abstract
The objective of this study has been to develop technologies that can reduce the content of active pharmaceutical ingredients (APIs) and bacteria from hospital wastewater. The results from the laboratory-and pilot-scale testings showed that efficient removal of the vast majority of APIs could be achieved by a membrane bioreactor (MBR) followed by ozone, ozone + hydrogen peroxide or powdered activated carbon (PAC). Chlorine dioxide (ClO2) was significantly less effective. MBR + PAC (450 mg/l) was the most efficient technology, while the most cost-efficient technology was MBR + ozone (156 mg O-3/l applied over 20 min). With MBR an efficient removal of Escherichia coli and enterococci was measured, and no antibiotic resistant bacteria were... (More)
The objective of this study has been to develop technologies that can reduce the content of active pharmaceutical ingredients (APIs) and bacteria from hospital wastewater. The results from the laboratory-and pilot-scale testings showed that efficient removal of the vast majority of APIs could be achieved by a membrane bioreactor (MBR) followed by ozone, ozone + hydrogen peroxide or powdered activated carbon (PAC). Chlorine dioxide (ClO2) was significantly less effective. MBR + PAC (450 mg/l) was the most efficient technology, while the most cost-efficient technology was MBR + ozone (156 mg O-3/l applied over 20 min). With MBR an efficient removal of Escherichia coli and enterococci was measured, and no antibiotic resistant bacteria were detected in the effluent. With MBR + ozone and MBR + PAC also the measured effluent concentrations of APIs (e.g. ciprofloxacin, sulfamethoxazole and sulfamethizole) were below available predicted no-effect concentrations (PNEC) for the marine environment without dilution. Iodinated contrast media were also reduced significantly (80-99% for iohexol, iopromide and ioversol and 40-99% for amidotrizoateacid). A full-scale MBR treatment plant with ozone at a hospital with 900 beds is estimated to require an investment cost of (sic)1.6 mill. and an operating cost of (sic)1/m(3) of treated water. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Advanced oxidation processes, bacteria, hospital wastewater, MBR, pharmaceuticals
in
Water Science and Technology
volume
67
issue
4
pages
854 - 862
publisher
IWA Publishing
external identifiers
  • wos:000315194900021
  • scopus:84874927702
  • pmid:23306265
ISSN
0273-1223
DOI
10.2166/wst.2012.645
language
English
LU publication?
yes
id
8d6a2e8c-0a32-4f95-b36f-ade49ff0a49c (old id 3671405)
date added to LUP
2016-04-01 14:04:18
date last changed
2025-10-14 11:16:39
@article{8d6a2e8c-0a32-4f95-b36f-ade49ff0a49c,
  abstract     = {{The objective of this study has been to develop technologies that can reduce the content of active pharmaceutical ingredients (APIs) and bacteria from hospital wastewater. The results from the laboratory-and pilot-scale testings showed that efficient removal of the vast majority of APIs could be achieved by a membrane bioreactor (MBR) followed by ozone, ozone + hydrogen peroxide or powdered activated carbon (PAC). Chlorine dioxide (ClO2) was significantly less effective. MBR + PAC (450 mg/l) was the most efficient technology, while the most cost-efficient technology was MBR + ozone (156 mg O-3/l applied over 20 min). With MBR an efficient removal of Escherichia coli and enterococci was measured, and no antibiotic resistant bacteria were detected in the effluent. With MBR + ozone and MBR + PAC also the measured effluent concentrations of APIs (e.g. ciprofloxacin, sulfamethoxazole and sulfamethizole) were below available predicted no-effect concentrations (PNEC) for the marine environment without dilution. Iodinated contrast media were also reduced significantly (80-99% for iohexol, iopromide and ioversol and 40-99% for amidotrizoateacid). A full-scale MBR treatment plant with ozone at a hospital with 900 beds is estimated to require an investment cost of (sic)1.6 mill. and an operating cost of (sic)1/m(3) of treated water.}},
  author       = {{Nielsen, U. and Hastrup, C. and Klausen, M. M. and Pedersen, B. M. and Kristensen, G. H. and la Cour Jansen, Jes and Bak, S. N. and Tuerk, J.}},
  issn         = {{0273-1223}},
  keywords     = {{Advanced oxidation processes; bacteria; hospital wastewater; MBR; pharmaceuticals}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{854--862}},
  publisher    = {{IWA Publishing}},
  series       = {{Water Science and Technology}},
  title        = {{Removal of APIs and bacteria from hospital wastewater by MBR plus O-3, O-3 + H2O2, PAC or ClO2}},
  url          = {{http://dx.doi.org/10.2166/wst.2012.645}},
  doi          = {{10.2166/wst.2012.645}},
  volume       = {{67}},
  year         = {{2013}},
}