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The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations

Irestorm, Elin LU orcid ; Meeteren, Antoinette Y N Schouten van ; van Gorp, Marloes ; Twisk, Jos W R ; Van Santen, Hanneke M. ; Partanen, Marita ; Grootenhuis, Martha A. and van Litsenburg, Raphaele R.L. (2024) In Pediatric Blood & Cancer p.1-9
Abstract
Background
Children and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.

Methods
Fatigue was assessed 1235 times for 425 participants. Self-report versions of PedsQL Multidimensional Fatigue Scale were used to repeatedly assess fatigue from the end of treatment up to 8 years later. Mixed models were used to analyze fatigue over time and determinants separately for infratentorial (N = 205), supratentorial hemispheric (N = 91), and supratentorial... (More)
Background
Children and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.

Methods
Fatigue was assessed 1235 times for 425 participants. Self-report versions of PedsQL Multidimensional Fatigue Scale were used to repeatedly assess fatigue from the end of treatment up to 8 years later. Mixed models were used to analyze fatigue over time and determinants separately for infratentorial (N = 205), supratentorial hemispheric (N = 91), and supratentorial midline tumors (N = 129).

Results
Cognitive fatigue worsened with time, while sleep-rest and general fatigue first decreased and then increased. There was no difference in fatigue between the tumor locations, but the risk factors differed when stratified by location. Radiotherapy was associated with more fatigue for infratentorial tumors, and centralization of care was associated with less fatigue for the supratentorial midline tumors. For supratentorial hemispheric tumors, female sex was associated with more fatigue. Higher parental education was associated with less fatigue regardless of tumor location.

Conclusions
The development of fatigue seems to be more related to sociodemographic and treatment variables than to tumor location. Healthcare providers need to be aware that fatigue may develop in the years following end of treatment, and that patients with a low/middle educational family background might be more vulnerable and in need of targeted support. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Pediatric Blood & Cancer
article number
e31028
pages
1 - 9
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:38698502
ISSN
1545-5017
DOI
10.1002/pbc.31028
language
English
LU publication?
yes
id
8d8b1adf-60ea-4aab-a9da-3c582dff58dd
date added to LUP
2024-05-03 08:49:37
date last changed
2024-05-04 03:00:08
@article{8d8b1adf-60ea-4aab-a9da-3c582dff58dd,
  abstract     = {{Background<br/>Children and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.<br/><br/>Methods<br/>Fatigue was assessed 1235 times for 425 participants. Self-report versions of PedsQL Multidimensional Fatigue Scale were used to repeatedly assess fatigue from the end of treatment up to 8 years later. Mixed models were used to analyze fatigue over time and determinants separately for infratentorial (N = 205), supratentorial hemispheric (N = 91), and supratentorial midline tumors (N = 129).<br/><br/>Results<br/>Cognitive fatigue worsened with time, while sleep-rest and general fatigue first decreased and then increased. There was no difference in fatigue between the tumor locations, but the risk factors differed when stratified by location. Radiotherapy was associated with more fatigue for infratentorial tumors, and centralization of care was associated with less fatigue for the supratentorial midline tumors. For supratentorial hemispheric tumors, female sex was associated with more fatigue. Higher parental education was associated with less fatigue regardless of tumor location.<br/><br/>Conclusions<br/>The development of fatigue seems to be more related to sociodemographic and treatment variables than to tumor location. Healthcare providers need to be aware that fatigue may develop in the years following end of treatment, and that patients with a low/middle educational family background might be more vulnerable and in need of targeted support.}},
  author       = {{Irestorm, Elin and Meeteren, Antoinette Y N Schouten van and van Gorp, Marloes and Twisk, Jos W R and Van Santen, Hanneke M. and Partanen, Marita and Grootenhuis, Martha A. and van Litsenburg, Raphaele R.L.}},
  issn         = {{1545-5017}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{1--9}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Pediatric Blood & Cancer}},
  title        = {{The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations}},
  url          = {{http://dx.doi.org/10.1002/pbc.31028}},
  doi          = {{10.1002/pbc.31028}},
  year         = {{2024}},
}