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Maternal selenium status and neuropsychological development in Spanish preschool children

Amorós, Rubén ; Murcia, Mario ; González, Llúcia ; Rebagliato, Marisa ; Iñiguez, Carmen ; Lopez-Espinosa, Maria-Jose ; Vioque, Jesús ; Broberg, Karin LU orcid ; Ballester, Ferran and Llop, Sabrina (2018) In Environmental Research 166. p.215-222
Abstract

BACKGROUND: The relationship between maternal selenium (Se) status and child neurodevelopment has been scarcely assessed. In a previous study we observed an inverse U-shaped association between maternal Se concentrations and infant neurodevelopment at 12 months of age. In this study, this non-linear association was explored at preschool age. The effect modification by breastfeeding, child's sex and cord blood mercury was also evaluated.

METHODS: Study subjects were 490 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2012). Child neuropsychological development was assessed at around 5 years of age by the McCarthy Scales of Children's Abilities (MSCA). Sociodemographic and dietary characteristics... (More)

BACKGROUND: The relationship between maternal selenium (Se) status and child neurodevelopment has been scarcely assessed. In a previous study we observed an inverse U-shaped association between maternal Se concentrations and infant neurodevelopment at 12 months of age. In this study, this non-linear association was explored at preschool age. The effect modification by breastfeeding, child's sex and cord blood mercury was also evaluated.

METHODS: Study subjects were 490 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2012). Child neuropsychological development was assessed at around 5 years of age by the McCarthy Scales of Children's Abilities (MSCA). Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation and at 5 years of age. Se was measured in serum samples by ICP-MS at the end of the first trimester of pregnancy (mean ± standard deviation (SD) = 12.4 ± 0.6 weeks of gestation).

RESULTS: The mean ± SD of maternal serum Se concentrations was 79.9 ± 8.1 µg/L. In multivariate analysis, no linear association was found between Se concentrations and the nine MSCA scales. Generalized additive models indicated inverted U-shaped relationships between Se concentrations and the verbal and global memory scales. When assessing the influence of effect modifiers, breastfeeding played a role: the association between Se and neuropsychological development was inverted U-shaped for the quantitative, general cognitive, working memory, fine motor, global motor and executive function scales only for non-breastfed children.

CONCLUSION: Low and high maternal Se concentrations seem to be harmful for child neuropsychological development, however further studies should explore this non-linear relationship.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Research
volume
166
pages
8 pages
publisher
Elsevier
external identifiers
  • pmid:29890426
  • scopus:85048625784
ISSN
1096-0953
DOI
10.1016/j.envres.2018.06.002
language
English
LU publication?
no
id
8d946120-b583-47a1-8d2f-8c740232ddc2
date added to LUP
2019-02-08 13:48:06
date last changed
2024-08-07 10:11:35
@article{8d946120-b583-47a1-8d2f-8c740232ddc2,
  abstract     = {{<p>BACKGROUND: The relationship between maternal selenium (Se) status and child neurodevelopment has been scarcely assessed. In a previous study we observed an inverse U-shaped association between maternal Se concentrations and infant neurodevelopment at 12 months of age. In this study, this non-linear association was explored at preschool age. The effect modification by breastfeeding, child's sex and cord blood mercury was also evaluated.</p><p>METHODS: Study subjects were 490 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2012). Child neuropsychological development was assessed at around 5 years of age by the McCarthy Scales of Children's Abilities (MSCA). Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation and at 5 years of age. Se was measured in serum samples by ICP-MS at the end of the first trimester of pregnancy (mean ± standard deviation (SD) = 12.4 ± 0.6 weeks of gestation).</p><p>RESULTS: The mean ± SD of maternal serum Se concentrations was 79.9 ± 8.1 µg/L. In multivariate analysis, no linear association was found between Se concentrations and the nine MSCA scales. Generalized additive models indicated inverted U-shaped relationships between Se concentrations and the verbal and global memory scales. When assessing the influence of effect modifiers, breastfeeding played a role: the association between Se and neuropsychological development was inverted U-shaped for the quantitative, general cognitive, working memory, fine motor, global motor and executive function scales only for non-breastfed children.</p><p>CONCLUSION: Low and high maternal Se concentrations seem to be harmful for child neuropsychological development, however further studies should explore this non-linear relationship.</p>}},
  author       = {{Amorós, Rubén and Murcia, Mario and González, Llúcia and Rebagliato, Marisa and Iñiguez, Carmen and Lopez-Espinosa, Maria-Jose and Vioque, Jesús and Broberg, Karin and Ballester, Ferran and Llop, Sabrina}},
  issn         = {{1096-0953}},
  language     = {{eng}},
  pages        = {{215--222}},
  publisher    = {{Elsevier}},
  series       = {{Environmental Research}},
  title        = {{Maternal selenium status and neuropsychological development in Spanish preschool children}},
  url          = {{http://dx.doi.org/10.1016/j.envres.2018.06.002}},
  doi          = {{10.1016/j.envres.2018.06.002}},
  volume       = {{166}},
  year         = {{2018}},
}