Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Significance of platinum distribution to predict platinum resistance in ovarian cancer after platinum treatment in neoadjuvant chemotherapy

Uno, Kaname LU orcid ; Yoshikawa, Nobuhisa ; Tazaki, Akira ; Ohnuma, Shoko ; Kitami, Kazuhisa ; Iyoshi, Shohei ; Mogi, Kazumasa ; Yoshihara, Masato ; Koya, Yoshihiro and Sugiyama, Mai , et al. (2022) In Scientific Reports 12.
Abstract

Most patients with ovarian cancer experience recurrence and develop resistance to platinum-based agents. The diagnosis of platinum resistance based on the platinum-free interval is not always accurate and timely in clinical settings. Herein, we used laser ablation inductively coupled plasma mass spectrometry to visualize the platinum distribution in the ovarian cancer tissues at the time of interval debulking surgery after neoadjuvant chemotherapy in 27patients with advanced high-grade serous ovarian cancer. Two distinct patterns of platinum distribution were observed. Type A (n = 16): platinum accumulation at the adjacent stroma but little in the tumor; type B (n = 11): even distribution of platinum throughout the tumor and adjacent... (More)

Most patients with ovarian cancer experience recurrence and develop resistance to platinum-based agents. The diagnosis of platinum resistance based on the platinum-free interval is not always accurate and timely in clinical settings. Herein, we used laser ablation inductively coupled plasma mass spectrometry to visualize the platinum distribution in the ovarian cancer tissues at the time of interval debulking surgery after neoadjuvant chemotherapy in 27patients with advanced high-grade serous ovarian cancer. Two distinct patterns of platinum distribution were observed. Type A (n = 16): platinum accumulation at the adjacent stroma but little in the tumor; type B (n = 11): even distribution of platinum throughout the tumor and adjacent stroma. The type A patients treated post-surgery with platinum-based adjuvant chemotherapy showed significantly shorter periods of recurrence after the last platinum-based chemotherapy session (p = 0.020) and were diagnosed with “platinum-resistant recurrence”. Moreover, type A was significantly correlated with worse prognosis (p = 0.031). Post-surgery treatment with non-platinum-based chemotherapy could be effective for the patients classified as type A. Our findings indicate that the platinum resistance can be predicted prior to recurrence, based on the platinum distribution; this could contribute to the selection of more appropriate adjuvant chemotherapy, which may lead to improves prognoses.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
12
article number
4513
publisher
Nature Publishing Group
external identifiers
  • pmid:35296733
  • scopus:85126313110
ISSN
2045-2322
DOI
10.1038/s41598-022-08503-7
language
English
LU publication?
yes
id
8d9e166c-4890-4fba-b9b2-e7b6117fdd6d
date added to LUP
2022-06-08 11:53:25
date last changed
2024-06-13 13:55:11
@article{8d9e166c-4890-4fba-b9b2-e7b6117fdd6d,
  abstract     = {{<p>Most patients with ovarian cancer experience recurrence and develop resistance to platinum-based agents. The diagnosis of platinum resistance based on the platinum-free interval is not always accurate and timely in clinical settings. Herein, we used laser ablation inductively coupled plasma mass spectrometry to visualize the platinum distribution in the ovarian cancer tissues at the time of interval debulking surgery after neoadjuvant chemotherapy in 27patients with advanced high-grade serous ovarian cancer. Two distinct patterns of platinum distribution were observed. Type A (n = 16): platinum accumulation at the adjacent stroma but little in the tumor; type B (n = 11): even distribution of platinum throughout the tumor and adjacent stroma. The type A patients treated post-surgery with platinum-based adjuvant chemotherapy showed significantly shorter periods of recurrence after the last platinum-based chemotherapy session (p = 0.020) and were diagnosed with “platinum-resistant recurrence”. Moreover, type A was significantly correlated with worse prognosis (p = 0.031). Post-surgery treatment with non-platinum-based chemotherapy could be effective for the patients classified as type A. Our findings indicate that the platinum resistance can be predicted prior to recurrence, based on the platinum distribution; this could contribute to the selection of more appropriate adjuvant chemotherapy, which may lead to improves prognoses.</p>}},
  author       = {{Uno, Kaname and Yoshikawa, Nobuhisa and Tazaki, Akira and Ohnuma, Shoko and Kitami, Kazuhisa and Iyoshi, Shohei and Mogi, Kazumasa and Yoshihara, Masato and Koya, Yoshihiro and Sugiyama, Mai and Tamauchi, Satoshi and Ikeda, Yoshiki and Yokoi, Akira and Kikkawa, Fumitaka and Kato, Masashi and Kajiyama, Hiroaki}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Significance of platinum distribution to predict platinum resistance in ovarian cancer after platinum treatment in neoadjuvant chemotherapy}},
  url          = {{http://dx.doi.org/10.1038/s41598-022-08503-7}},
  doi          = {{10.1038/s41598-022-08503-7}},
  volume       = {{12}},
  year         = {{2022}},
}