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Excitatory amino acid receptors and ischemic brain damage in the rat

Westerberg, Eva ; Monaghan, Daniel T. ; Cotman, Carl W. and Wieloch, Tadeusz LU (1987) In Neuroscience Letters 73(2). p.119-124
Abstract

The excitatory amino acid glutamate has been suggested to be an important mediator of the selective CA1 hippocampal damage which follows transient cerebral ischemia. In order to evaluate the possible involvement of altered glutamate receptor regulation in the expression of the delayed neuronal necrosis following ischemia, we have determined the density of glutamate receptor subtypes in the rat hippocampus following transient ischemia. We report a transient reversible decrease in [3H]AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding sites (presumably representing quisqualate receptors) followed by a long term loss of binding at 2 days postischemia which precedes neuronal loss. In contrast, no... (More)

The excitatory amino acid glutamate has been suggested to be an important mediator of the selective CA1 hippocampal damage which follows transient cerebral ischemia. In order to evaluate the possible involvement of altered glutamate receptor regulation in the expression of the delayed neuronal necrosis following ischemia, we have determined the density of glutamate receptor subtypes in the rat hippocampus following transient ischemia. We report a transient reversible decrease in [3H]AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding sites (presumably representing quisqualate receptors) followed by a long term loss of binding at 2 days postischemia which precedes neuronal loss. In contrast, no change was noted in the N-methyl-d-aspartate or kainic acid binding sites over this time period.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain damage, Glutamate receptor, Hippocampus, Ischemia
in
Neuroscience Letters
volume
73
issue
2
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:0023089706
  • pmid:2881232
ISSN
0304-3940
DOI
10.1016/0304-3940(87)90004-8
language
English
LU publication?
yes
id
8da9e001-cd6d-47c4-b5e6-d5b8b40a370f
date added to LUP
2019-06-13 17:40:47
date last changed
2024-01-01 10:30:37
@article{8da9e001-cd6d-47c4-b5e6-d5b8b40a370f,
  abstract     = {{<p>The excitatory amino acid glutamate has been suggested to be an important mediator of the selective CA<sub>1</sub> hippocampal damage which follows transient cerebral ischemia. In order to evaluate the possible involvement of altered glutamate receptor regulation in the expression of the delayed neuronal necrosis following ischemia, we have determined the density of glutamate receptor subtypes in the rat hippocampus following transient ischemia. We report a transient reversible decrease in [<sup>3</sup>H]AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding sites (presumably representing quisqualate receptors) followed by a long term loss of binding at 2 days postischemia which precedes neuronal loss. In contrast, no change was noted in the N-methyl-d-aspartate or kainic acid binding sites over this time period.</p>}},
  author       = {{Westerberg, Eva and Monaghan, Daniel T. and Cotman, Carl W. and Wieloch, Tadeusz}},
  issn         = {{0304-3940}},
  keywords     = {{Brain damage; Glutamate receptor; Hippocampus; Ischemia}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2}},
  pages        = {{119--124}},
  publisher    = {{Elsevier}},
  series       = {{Neuroscience Letters}},
  title        = {{Excitatory amino acid receptors and ischemic brain damage in the rat}},
  url          = {{http://dx.doi.org/10.1016/0304-3940(87)90004-8}},
  doi          = {{10.1016/0304-3940(87)90004-8}},
  volume       = {{73}},
  year         = {{1987}},
}