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Cerebrospinal fluid concentrations of extracellular matrix proteins in Alzheimer's disease

Minta, Karolina; Portelius, Erik; Janelidze, Shorena LU ; Hansson, Oskar LU ; Zetterberg, Henrik LU ; Blennow, Kaj LU and Andreasson, Ulf (2019) In Journal of Alzheimer's Disease 69(4). p.1213-1220
Abstract

Background: Brevican, neurocan, tenascin-C, and tenascin-R are extracellular matrix (ECM) proteins that are mainly expressed in the brain. They play important roles in proliferation and migration of neurons and other cell types in the brain. These ECM proteins may also be involved in various pathologies, including reactive gliosis. Objective: The aim of the study was to investigate if ECM protein concentrations in cerebrospinal fluid (CSF) are linked to the neurodegenerative process in Alzheimer's disease (AD). Methods: Lumbar CSF samples from a non-AD control group (n = 50) and a clinically diagnosedADgroup (n = 42), matched for age and gender, were analyzed using commercially available ELISAs detecting ECM proteins. Mann-Whitney U... (More)

Background: Brevican, neurocan, tenascin-C, and tenascin-R are extracellular matrix (ECM) proteins that are mainly expressed in the brain. They play important roles in proliferation and migration of neurons and other cell types in the brain. These ECM proteins may also be involved in various pathologies, including reactive gliosis. Objective: The aim of the study was to investigate if ECM protein concentrations in cerebrospinal fluid (CSF) are linked to the neurodegenerative process in Alzheimer's disease (AD). Methods: Lumbar CSF samples from a non-AD control group (n = 50) and a clinically diagnosedADgroup (n = 42), matched for age and gender, were analyzed using commercially available ELISAs detecting ECM proteins. Mann-Whitney U test was used to examine group differences, while Spearman's rho test was used for correlations. Results: Brevican, neurocan, tenascin-R, and tenascin-C concentrations in AD patients did not differ compared to healthy controls or when the groups were dichotomized based on the Aβ42/40 cut-off. CSF tenascin-C and tenascin-R concentrations were significantly higher in women than in men in the AD group (p = 0.02). Conclusion: ECM proteins do not reflect AD-pathology in CSF. CSF tenascin-C and tenascin-R upregulation in women possibly reveal sexual dimorphism in the central nervous system immunity during AD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Brevican, Neurocan, Tenascin-C, Tenascin-R
in
Journal of Alzheimer's Disease
volume
69
issue
4
pages
8 pages
publisher
IOS Press
external identifiers
  • scopus:85067574117
ISSN
1387-2877
DOI
10.3233/JAD-190187
language
English
LU publication?
yes
id
8db26f45-895f-40d6-8382-aa3698fd7112
date added to LUP
2019-07-08 11:33:01
date last changed
2019-07-30 05:06:21
@article{8db26f45-895f-40d6-8382-aa3698fd7112,
  abstract     = {<p>Background: Brevican, neurocan, tenascin-C, and tenascin-R are extracellular matrix (ECM) proteins that are mainly expressed in the brain. They play important roles in proliferation and migration of neurons and other cell types in the brain. These ECM proteins may also be involved in various pathologies, including reactive gliosis. Objective: The aim of the study was to investigate if ECM protein concentrations in cerebrospinal fluid (CSF) are linked to the neurodegenerative process in Alzheimer's disease (AD). Methods: Lumbar CSF samples from a non-AD control group (n = 50) and a clinically diagnosedADgroup (n = 42), matched for age and gender, were analyzed using commercially available ELISAs detecting ECM proteins. Mann-Whitney U test was used to examine group differences, while Spearman's rho test was used for correlations. Results: Brevican, neurocan, tenascin-R, and tenascin-C concentrations in AD patients did not differ compared to healthy controls or when the groups were dichotomized based on the Aβ<sub>42/40</sub> cut-off. CSF tenascin-C and tenascin-R concentrations were significantly higher in women than in men in the AD group (p = 0.02). Conclusion: ECM proteins do not reflect AD-pathology in CSF. CSF tenascin-C and tenascin-R upregulation in women possibly reveal sexual dimorphism in the central nervous system immunity during AD.</p>},
  author       = {Minta, Karolina and Portelius, Erik and Janelidze, Shorena and Hansson, Oskar and Zetterberg, Henrik and Blennow, Kaj and Andreasson, Ulf},
  issn         = {1387-2877},
  keyword      = {Alzheimer's disease,Brevican,Neurocan,Tenascin-C,Tenascin-R},
  language     = {eng},
  number       = {4},
  pages        = {1213--1220},
  publisher    = {IOS Press},
  series       = {Journal of Alzheimer's Disease},
  title        = {Cerebrospinal fluid concentrations of extracellular matrix proteins in Alzheimer's disease},
  url          = {http://dx.doi.org/10.3233/JAD-190187},
  volume       = {69},
  year         = {2019},
}