Patterns of failure for patients with glioblastoma following O-(2-[18F]fluoroethyl)-L-tyrosine PET- and MRI-guided radiotherapy
Lundemann, Michael ; Costa, Junia Cardoso ; Law, Ian ; Engelholm, Svend Aage ; Muhic, Aida ; Poulsen, Hans Skovgaard and Munck af Rosenschold, Per LU
(2017)
In Radiotherapy and Oncology
122(3).
p.380-386
- Abstract
Background and purpose To evaluate the patterns of failure following clinical introduction of amino-acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET-guided target definition for radiotherapy (RT) of glioblastoma patients. Materials and methods The first 66 consecutive patients with confirmed histology, scanned using FET-PET/CT and MRI were selected for evaluation. Chemo-radiotherapy was delivered to a volume based on both MRI and FET-PET (PETvol). The volume of recurrence (RV) was defined on MRI data collected at the time of progression according to RANO criteria. Results Fifty patients were evaluable, with median follow-up of 45 months. Central, in-field, marginal and distant recurrences were observed for 82%,... (More)
Background and purpose To evaluate the patterns of failure following clinical introduction of amino-acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET-guided target definition for radiotherapy (RT) of glioblastoma patients. Materials and methods The first 66 consecutive patients with confirmed histology, scanned using FET-PET/CT and MRI were selected for evaluation. Chemo-radiotherapy was delivered to a volume based on both MRI and FET-PET (PETvol). The volume of recurrence (RV) was defined on MRI data collected at the time of progression according to RANO criteria. Results Fifty patients were evaluable, with median follow-up of 45 months. Central, in-field, marginal and distant recurrences were observed for 82%, 10%, 2%, and 6% of the patients, respectively. We found a volumetric overlap of 26%, 31% and 39% of the RV with the contrast-enhancing MR volume, PETvol and the composite MRPETvol, respectively. MGMT-methylation (p = 0.03), larger PETvol (p < 0.001), and less extensive surgery (p < 0.001), were associated with larger PETvol overlap. Conclusion The combined MRPETvol had a stronger association with the recurrence volume than either of the modalities alone. Larger overlap of PETvol and RV was observed for patients with MGMT-methylation, less extensive surgery, and large PETvol on the RT-planning scans.
(Less)
- author
- Lundemann, Michael
; Costa, Junia Cardoso
; Law, Ian
; Engelholm, Svend Aage
; Muhic, Aida
; Poulsen, Hans Skovgaard
and Munck af Rosenschold, Per
LU
- publishing date
- 2017-03-01
- type
- Contribution to journal
- publication status
- published
- keywords
- FET-PET, Glioma, MRI, Radiotherapy, Recurrence patterns
- in
- Radiotherapy and Oncology
- volume
- 122
- issue
- 3
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:28110959
- scopus:85009742539
- ISSN
- 0167-8140
- DOI
- 10.1016/j.radonc.2017.01.002
- language
- English
- LU publication?
- no
- id
- 8dbea5b3-f648-477b-9d54-ab14c6ee12e1
- date added to LUP
- 2020-07-28 09:02:04
- date last changed
- 2024-04-17 14:54:55
@article{8dbea5b3-f648-477b-9d54-ab14c6ee12e1,
abstract = {{<p>Background and purpose To evaluate the patterns of failure following clinical introduction of amino-acid O-(2-[<sup>18</sup>F]fluoroethyl)-L-tyrosine (FET)-PET-guided target definition for radiotherapy (RT) of glioblastoma patients. Materials and methods The first 66 consecutive patients with confirmed histology, scanned using FET-PET/CT and MRI were selected for evaluation. Chemo-radiotherapy was delivered to a volume based on both MRI and FET-PET (PET<sub>vol</sub>). The volume of recurrence (RV) was defined on MRI data collected at the time of progression according to RANO criteria. Results Fifty patients were evaluable, with median follow-up of 45 months. Central, in-field, marginal and distant recurrences were observed for 82%, 10%, 2%, and 6% of the patients, respectively. We found a volumetric overlap of 26%, 31% and 39% of the RV with the contrast-enhancing MR volume, PET<sub>vol</sub> and the composite MRPET<sub>vol</sub>, respectively. MGMT-methylation (p = 0.03), larger PET<sub>vol</sub> (p < 0.001), and less extensive surgery (p < 0.001), were associated with larger PET<sub>vol</sub> overlap. Conclusion The combined MRPET<sub>vol</sub> had a stronger association with the recurrence volume than either of the modalities alone. Larger overlap of PET<sub>vol</sub> and RV was observed for patients with MGMT-methylation, less extensive surgery, and large PET<sub>vol</sub> on the RT-planning scans.</p>}},
author = {{Lundemann, Michael and Costa, Junia Cardoso and Law, Ian and Engelholm, Svend Aage and Muhic, Aida and Poulsen, Hans Skovgaard and Munck af Rosenschold, Per}},
issn = {{0167-8140}},
keywords = {{FET-PET; Glioma; MRI; Radiotherapy; Recurrence patterns}},
language = {{eng}},
month = {{03}},
number = {{3}},
pages = {{380--386}},
publisher = {{Elsevier}},
series = {{Radiotherapy and Oncology}},
title = {{Patterns of failure for patients with glioblastoma following O-(2-[<sup>18</sup>F]fluoroethyl)-L-tyrosine PET- and MRI-guided radiotherapy}},
url = {{http://dx.doi.org/10.1016/j.radonc.2017.01.002}},
doi = {{10.1016/j.radonc.2017.01.002}},
volume = {{122}},
year = {{2017}},
}