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A retrospective investigation of hexavalent chromium allergy in southern Sweden

Lejding, Tina LU ; Mowitz, Martin LU ; Isaksson, Marléne LU ; Bruze, Magnus LU ; Pontén, Ann LU ; Svedman, Cecilia LU ; Zimerson, Erik LU and Engfeldt, Malin LU (2018) In Contact Dermatitis
Abstract

Background: Historically, allergic contact dermatitis caused by hexavalent chromium [Cr(VI)] in cement was the most common cause of invalidity attributable to skin disease in Sweden. Since the legislation to reduce Cr(VI) in cement was introduced in 1989, we rarely see allergic contact dermatitis caused by cement. Objectives: To examine the frequency of contact allergy to Cr(VI) in southern Sweden in 2005-2014. Methods: We investigated the occurrence of positive reactions to potassium dichromate 0.5% pet. in consecutively tested dermatitis patients, and compared the occurrence of atopic dermatitis, localization of dermatitis and simultaneous positive reactions to cobalt chloride and nickel sulfate in the Cr(VI)-positive patients with... (More)

Background: Historically, allergic contact dermatitis caused by hexavalent chromium [Cr(VI)] in cement was the most common cause of invalidity attributable to skin disease in Sweden. Since the legislation to reduce Cr(VI) in cement was introduced in 1989, we rarely see allergic contact dermatitis caused by cement. Objectives: To examine the frequency of contact allergy to Cr(VI) in southern Sweden in 2005-2014. Methods: We investigated the occurrence of positive reactions to potassium dichromate 0.5% pet. in consecutively tested dermatitis patients, and compared the occurrence of atopic dermatitis, localization of dermatitis and simultaneous positive reactions to cobalt chloride and nickel sulfate in the Cr(VI)-positive patients with those in a group of patients with a similar age and sex distribution. Results: In total, 6482 patients were tested, and 233 Cr(VI)-allergic individuals were found (3.6%). A significantly higher proportion of atopic dermatitis was found among Cr(VI)-allergic patients, and a significantly higher share of foot dermatitis was found among Cr(VI)-allergic women, than among controls. Cr(VI) allergy was less likely when both nickel allergy and cobalt allergy were present. Conclusion: A relatively high frequency of contact allergy to Cr(VI) was found. The cause has shifted from cement exposure to other exposures, probably mainly leather.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Allergic contact dermatitis, Asthma, Atopic dermatitis, Atopic rhinitis, Atopy, Dichromate, Hexavalent chromium, Trivalent chromium
in
Contact Dermatitis
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85044324044
ISSN
0105-1873
DOI
10.1111/cod.12969
language
English
LU publication?
yes
id
8e15688b-8367-4f53-aa4e-1b075baf0a2c
date added to LUP
2018-04-09 12:18:58
date last changed
2018-10-03 10:41:37
@article{8e15688b-8367-4f53-aa4e-1b075baf0a2c,
  abstract     = {<p>Background: Historically, allergic contact dermatitis caused by hexavalent chromium [Cr(VI)] in cement was the most common cause of invalidity attributable to skin disease in Sweden. Since the legislation to reduce Cr(VI) in cement was introduced in 1989, we rarely see allergic contact dermatitis caused by cement. Objectives: To examine the frequency of contact allergy to Cr(VI) in southern Sweden in 2005-2014. Methods: We investigated the occurrence of positive reactions to potassium dichromate 0.5% pet. in consecutively tested dermatitis patients, and compared the occurrence of atopic dermatitis, localization of dermatitis and simultaneous positive reactions to cobalt chloride and nickel sulfate in the Cr(VI)-positive patients with those in a group of patients with a similar age and sex distribution. Results: In total, 6482 patients were tested, and 233 Cr(VI)-allergic individuals were found (3.6%). A significantly higher proportion of atopic dermatitis was found among Cr(VI)-allergic patients, and a significantly higher share of foot dermatitis was found among Cr(VI)-allergic women, than among controls. Cr(VI) allergy was less likely when both nickel allergy and cobalt allergy were present. Conclusion: A relatively high frequency of contact allergy to Cr(VI) was found. The cause has shifted from cement exposure to other exposures, probably mainly leather.</p>},
  author       = {Lejding, Tina and Mowitz, Martin and Isaksson, Marléne and Bruze, Magnus and Pontén, Ann and Svedman, Cecilia and Zimerson, Erik and Engfeldt, Malin},
  issn         = {0105-1873},
  keyword      = {Allergic contact dermatitis,Asthma,Atopic dermatitis,Atopic rhinitis,Atopy,Dichromate,Hexavalent chromium,Trivalent chromium},
  language     = {eng},
  month        = {03},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {A retrospective investigation of hexavalent chromium allergy in southern Sweden},
  url          = {http://dx.doi.org/10.1111/cod.12969},
  year         = {2018},
}