Islet transplantation in mice differing in the I and S subregions of the H-2 complex
Steffes, Michael W. ; Nielsen, Otto ; Dyrberg, Thomas ; Baekkeskov, Steinunn ; Scott, Joanne and Lernmark, Åke LU
(1981)
In Transplantation
31(6).
p.476-479
- Abstract
Diabetic A.TL and A.TH mice, congenic inbred strains differing only in the I and S (non-K, non-D) regions of the major histocompatibility (H-2) complex, received intrasplenic allogeneic and isogeneic pancreatic islet transplants. The isografts were uniformly accepted, while approximately 60% of the recipients receiving allografts rejected the islets, most within 4 weeks of transplantation. With either strain the animals accepting the allografts had higher blood glucose values than normal mice or isografted recipients. After a minimum of 13 weeks of nearly normal glucose levels, successfully alografted mice received skin grafts and spleen cells. None of the A.TH recipients rejected the A.TL islets, but two of four A.TL recipients of A.TH... (More)
Diabetic A.TL and A.TH mice, congenic inbred strains differing only in the I and S (non-K, non-D) regions of the major histocompatibility (H-2) complex, received intrasplenic allogeneic and isogeneic pancreatic islet transplants. The isografts were uniformly accepted, while approximately 60% of the recipients receiving allografts rejected the islets, most within 4 weeks of transplantation. With either strain the animals accepting the allografts had higher blood glucose values than normal mice or isografted recipients. After a minimum of 13 weeks of nearly normal glucose levels, successfully alografted mice received skin grafts and spleen cells. None of the A.TH recipients rejected the A.TL islets, but two of four A.TL recipients of A.TH islets became diabetic after the skin grafts. These observations suggest a variable response to islets transplanted across this isolated difference of the H-2 complex. Furthermore, allografted islets resisting rejection did not provide normal glucose levels in the recipients.
(Less)
- author
- Steffes, Michael W.
; Nielsen, Otto
; Dyrberg, Thomas
; Baekkeskov, Steinunn
; Scott, Joanne
and Lernmark, Åke
LU
- publishing date
- 1981-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Transplantation
- volume
- 31
- issue
- 6
- pages
- 476 - 479
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:6789509
- scopus:0019452645
- ISSN
- 0041-1337
- DOI
- 10.1097/00007890-198106000-00017
- language
- English
- LU publication?
- no
- id
- 8e28307b-7e65-4668-a5cc-bf29be1deab2
- date added to LUP
- 2019-09-16 15:35:23
- date last changed
- 2024-03-13 08:02:35
@article{8e28307b-7e65-4668-a5cc-bf29be1deab2,
abstract = {{<p>Diabetic A.TL and A.TH mice, congenic inbred strains differing only in the I and S (non-K, non-D) regions of the major histocompatibility (H-2) complex, received intrasplenic allogeneic and isogeneic pancreatic islet transplants. The isografts were uniformly accepted, while approximately 60% of the recipients receiving allografts rejected the islets, most within 4 weeks of transplantation. With either strain the animals accepting the allografts had higher blood glucose values than normal mice or isografted recipients. After a minimum of 13 weeks of nearly normal glucose levels, successfully alografted mice received skin grafts and spleen cells. None of the A.TH recipients rejected the A.TL islets, but two of four A.TL recipients of A.TH islets became diabetic after the skin grafts. These observations suggest a variable response to islets transplanted across this isolated difference of the H-2 complex. Furthermore, allografted islets resisting rejection did not provide normal glucose levels in the recipients.</p>}},
author = {{Steffes, Michael W. and Nielsen, Otto and Dyrberg, Thomas and Baekkeskov, Steinunn and Scott, Joanne and Lernmark, Åke}},
issn = {{0041-1337}},
language = {{eng}},
month = {{01}},
number = {{6}},
pages = {{476--479}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Transplantation}},
title = {{Islet transplantation in mice differing in the I and S subregions of the H-2 complex}},
url = {{http://dx.doi.org/10.1097/00007890-198106000-00017}},
doi = {{10.1097/00007890-198106000-00017}},
volume = {{31}},
year = {{1981}},
}