Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia
(2020) In Acta Paediatrica, International Journal of Paediatrics 109(4). p.679-687- Abstract
Aim: Studies indicate that reduced foetal haemoglobin levels are related to increased neonatal morbidity rates. This study investigated the relationships between sampling-related blood loss and adult blood transfusions administered during postnatal days 1-14 and the development of severe neonatal morbidities in extremely preterm infants born before 28 weeks of gestation. Methods: The medical files of 149 extremely preterm infants born at two university hospitals in Sweden from 2013 to 2018 were investigated. Results: Blood sampling resulted in a 58% depletion of the endogenous blood volume postnatal days 1-14 (median 40.4 mL/kg, interquartile range 23.9-53.3 mL/kg) and correlated with the adult erythrocyte transfusion volume... (More)
Aim: Studies indicate that reduced foetal haemoglobin levels are related to increased neonatal morbidity rates. This study investigated the relationships between sampling-related blood loss and adult blood transfusions administered during postnatal days 1-14 and the development of severe neonatal morbidities in extremely preterm infants born before 28 weeks of gestation. Methods: The medical files of 149 extremely preterm infants born at two university hospitals in Sweden from 2013 to 2018 were investigated. Results: Blood sampling resulted in a 58% depletion of the endogenous blood volume postnatal days 1-14 (median 40.4 mL/kg, interquartile range 23.9-53.3 mL/kg) and correlated with the adult erythrocyte transfusion volume (rS = 0.870, P <.001). Sampling-related blood loss on postnatal days 1-7, adjusted for gestational age at birth and birth weight standard deviation score, was associated with the development of bronchopulmonary dysplasia (BPD) (odds ratio by a 10-unit increase 2.4, 95% confidence interval 1.1-5.4) (P =.03). No associations were found between blood sampling and intraventricular haemorrhage or necrotising enterocolitis in the full statistical model. The largest proportion of sampling-related blood was used for blood gas analyses (48.7%). Conclusion: Diagnostic blood sampling led to major endogenous blood loss replaced with adult blood components and was associated with the development of BPD.
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- author
- Hellström, William ; Forssell, Linnéa ; Morsing, Eva LU ; Sävman, Karin and Ley, David LU
- organization
- publishing date
- 2020-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anaemia, blood sampling, bronchopulmonary dysplasia, extremely preterm, transfusion
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 109
- issue
- 4
- pages
- 9 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85073929106
- pmid:31505053
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.15003
- language
- English
- LU publication?
- yes
- id
- 8e2ea846-c39e-4b78-b16e-d0550bed3e60
- date added to LUP
- 2019-11-07 09:51:43
- date last changed
- 2024-06-13 05:51:40
@article{8e2ea846-c39e-4b78-b16e-d0550bed3e60,
abstract = {{<p>Aim: Studies indicate that reduced foetal haemoglobin levels are related to increased neonatal morbidity rates. This study investigated the relationships between sampling-related blood loss and adult blood transfusions administered during postnatal days 1-14 and the development of severe neonatal morbidities in extremely preterm infants born before 28 weeks of gestation. Methods: The medical files of 149 extremely preterm infants born at two university hospitals in Sweden from 2013 to 2018 were investigated. Results: Blood sampling resulted in a 58% depletion of the endogenous blood volume postnatal days 1-14 (median 40.4 mL/kg, interquartile range 23.9-53.3 mL/kg) and correlated with the adult erythrocyte transfusion volume (r<sub>S</sub> = 0.870, P <.001). Sampling-related blood loss on postnatal days 1-7, adjusted for gestational age at birth and birth weight standard deviation score, was associated with the development of bronchopulmonary dysplasia (BPD) (odds ratio by a 10-unit increase 2.4, 95% confidence interval 1.1-5.4) (P =.03). No associations were found between blood sampling and intraventricular haemorrhage or necrotising enterocolitis in the full statistical model. The largest proportion of sampling-related blood was used for blood gas analyses (48.7%). Conclusion: Diagnostic blood sampling led to major endogenous blood loss replaced with adult blood components and was associated with the development of BPD.</p>}},
author = {{Hellström, William and Forssell, Linnéa and Morsing, Eva and Sävman, Karin and Ley, David}},
issn = {{0803-5253}},
keywords = {{anaemia; blood sampling; bronchopulmonary dysplasia; extremely preterm; transfusion}},
language = {{eng}},
number = {{4}},
pages = {{679--687}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia}},
url = {{http://dx.doi.org/10.1111/apa.15003}},
doi = {{10.1111/apa.15003}},
volume = {{109}},
year = {{2020}},
}