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Long-term risk of renal and urinary tract diseases in childhood cancer survivors : A population-based cohort study

Bonnesen, Trine Gade; Winther, Jeanette F.; Asdahl, Peter H.; De Fine Licht, Sofie; Gudmundsdottir, Thorgerdur; Sällfors Holmqvist, Anna LU ; Madanat-Harjuoja, Laura Maria; Tryggvadottir, Laufey; Wesenberg, Finn and Birn, Henrik, et al. (2016) In European Journal of Cancer 64. p.52-61
Abstract

Background Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer registries and selected 211,156 population comparisons of a corresponding age, sex, and country of residence from the national population registries. To obtain information on all first-time hospitalizations for a urinary tract disease, we linked all study subjects to the national hospital registry of each country. Relative risks (RRs) and... (More)

Background Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer registries and selected 211,156 population comparisons of a corresponding age, sex, and country of residence from the national population registries. To obtain information on all first-time hospitalizations for a urinary tract disease, we linked all study subjects to the national hospital registry of each country. Relative risks (RRs) and absolute excess risks (AERs) and associated 95% confidence intervals (CIs) for urinary tract diseases among cancer survivors were calculated with the appropriate morbidity rates among comparisons as reference. Results We observed 1645 childhood cancer survivors ever hospitalized for urinary tract disease yielding an RR of 2.5 (95% CI 2.4-2.7) and an AER of 229 (95% CI 210-248) per 100,000 person-years. The cumulative risk at age 60 was 22% in cancer survivors and 10% in comparisons. Infections of the urinary system and chronic kidney disease showed the highest excess risks, whereas survivors of neuroblastoma, hepatic and renal tumours experienced the highest RRs. Conclusion Survivors of childhood cancer had an excess risk of urinary tract diseases and for most diseases the risk remained elevated throughout life. The highest risks occurred following therapy of childhood abdominal tumours.

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keywords
Childhood cancer, Late complications, Renal diseases, Survivorship, Urinary tract diseases
in
European Journal of Cancer
volume
64
pages
10 pages
publisher
Elsevier
external identifiers
  • Scopus:84975131390
  • WOS:000380750800006
ISSN
0959-8049
DOI
10.1016/j.ejca.2016.05.006
language
English
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yes
id
8e4268f8-65a8-47d1-9459-dba7afb996a9
date added to LUP
2016-07-06 14:36:21
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2017-01-01 08:29:55
@article{8e4268f8-65a8-47d1-9459-dba7afb996a9,
  abstract     = {<p>Background Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer registries and selected 211,156 population comparisons of a corresponding age, sex, and country of residence from the national population registries. To obtain information on all first-time hospitalizations for a urinary tract disease, we linked all study subjects to the national hospital registry of each country. Relative risks (RRs) and absolute excess risks (AERs) and associated 95% confidence intervals (CIs) for urinary tract diseases among cancer survivors were calculated with the appropriate morbidity rates among comparisons as reference. Results We observed 1645 childhood cancer survivors ever hospitalized for urinary tract disease yielding an RR of 2.5 (95% CI 2.4-2.7) and an AER of 229 (95% CI 210-248) per 100,000 person-years. The cumulative risk at age 60 was 22% in cancer survivors and 10% in comparisons. Infections of the urinary system and chronic kidney disease showed the highest excess risks, whereas survivors of neuroblastoma, hepatic and renal tumours experienced the highest RRs. Conclusion Survivors of childhood cancer had an excess risk of urinary tract diseases and for most diseases the risk remained elevated throughout life. The highest risks occurred following therapy of childhood abdominal tumours.</p>},
  author       = {Bonnesen, Trine Gade and Winther, Jeanette F. and Asdahl, Peter H. and De Fine Licht, Sofie and Gudmundsdottir, Thorgerdur and Sällfors Holmqvist, Anna and Madanat-Harjuoja, Laura Maria and Tryggvadottir, Laufey and Wesenberg, Finn and Birn, Henrik and Olsen, Jørgen H. and Hasle, Henrik},
  issn         = {0959-8049},
  keyword      = {Childhood cancer,Late complications,Renal diseases,Survivorship,Urinary tract diseases},
  language     = {eng},
  month        = {09},
  pages        = {52--61},
  publisher    = {Elsevier},
  series       = {European Journal of Cancer},
  title        = {Long-term risk of renal and urinary tract diseases in childhood cancer survivors : A population-based cohort study},
  url          = {http://dx.doi.org/10.1016/j.ejca.2016.05.006},
  volume       = {64},
  year         = {2016},
}