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Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; Association with systolic blood pressure in the high normal range

Rinnström, Daniel; Dellborg, Mikael; Thilén, Ulf LU ; Sörensson, Peder; Nielsen, Niels Eric; Christersson, Christina and Johansson, Bengt (2016) In International Journal of Cardiology 218. p.59-64
Abstract

Background Arterial hypertension is common in adults with repaired coarctation of the aorta (CoA). The associations between the diagnosis of hypertension, actual blood pressure, other factors affecting left ventricular overload, and left ventricular hypertrophy (LVH) are not yet fully explored in this population. Material and results From the national register for congenital heart disease, 506 adult patients (≥ 18 years old) with previous repair of CoA were identified (37.0% female, mean age 35.7 ± 13.8 years, with an average of 26.8 ± 12.4 years post repair). Echocardiographic data were available for all patients, and showed LVH in 114 (22.5%) of these. Systolic blood pressure (SBP) (mm Hg) (OR 1.02, CI 1.01-1.04), aortic valve... (More)

Background Arterial hypertension is common in adults with repaired coarctation of the aorta (CoA). The associations between the diagnosis of hypertension, actual blood pressure, other factors affecting left ventricular overload, and left ventricular hypertrophy (LVH) are not yet fully explored in this population. Material and results From the national register for congenital heart disease, 506 adult patients (≥ 18 years old) with previous repair of CoA were identified (37.0% female, mean age 35.7 ± 13.8 years, with an average of 26.8 ± 12.4 years post repair). Echocardiographic data were available for all patients, and showed LVH in 114 (22.5%) of these. Systolic blood pressure (SBP) (mm Hg) (OR 1.02, CI 1.01-1.04), aortic valve disease, (OR 2.17, CI 1.33-3.53), age (years) (OR 1.03, CI 1.01-1.05), diagnosis of arterial hypertension (OR 3.02, CI 1.81-5.02), and sex (female) (OR 0.41, CI 0.24-0.72) were independently associated with LVH. There was an association with LVH at SBP within the upper reference limits [130, 140] mm Hg (OR 2.23, CI 1.05-4.73) that further increased for SBP > 140 mm Hg (OR 8.02, CI 3.76-17.12). Conclusions LVH is common post repair of CoA and is associated with SBP even below the currently recommended target level. Lower target levels may therefore become justified in this population. ORCID Id: 0000-0003-0976-6910.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult congenital heart disease, CoA, Hypertension, Left ventricular hypertrophy
in
International Journal of Cardiology
volume
218
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:84969780771
  • wos:000377856300010
ISSN
0167-5273
DOI
10.1016/j.ijcard.2016.05.033
language
English
LU publication?
yes
id
8ef9a43b-7c65-468e-88be-b646a0f261ed
date added to LUP
2016-06-16 14:39:27
date last changed
2017-07-02 04:52:06
@article{8ef9a43b-7c65-468e-88be-b646a0f261ed,
  abstract     = {<p>Background Arterial hypertension is common in adults with repaired coarctation of the aorta (CoA). The associations between the diagnosis of hypertension, actual blood pressure, other factors affecting left ventricular overload, and left ventricular hypertrophy (LVH) are not yet fully explored in this population. Material and results From the national register for congenital heart disease, 506 adult patients (≥ 18 years old) with previous repair of CoA were identified (37.0% female, mean age 35.7 ± 13.8 years, with an average of 26.8 ± 12.4 years post repair). Echocardiographic data were available for all patients, and showed LVH in 114 (22.5%) of these. Systolic blood pressure (SBP) (mm Hg) (OR 1.02, CI 1.01-1.04), aortic valve disease, (OR 2.17, CI 1.33-3.53), age (years) (OR 1.03, CI 1.01-1.05), diagnosis of arterial hypertension (OR 3.02, CI 1.81-5.02), and sex (female) (OR 0.41, CI 0.24-0.72) were independently associated with LVH. There was an association with LVH at SBP within the upper reference limits [130, 140] mm Hg (OR 2.23, CI 1.05-4.73) that further increased for SBP &gt; 140 mm Hg (OR 8.02, CI 3.76-17.12). Conclusions LVH is common post repair of CoA and is associated with SBP even below the currently recommended target level. Lower target levels may therefore become justified in this population. ORCID Id: 0000-0003-0976-6910.</p>},
  author       = {Rinnström, Daniel and Dellborg, Mikael and Thilén, Ulf and Sörensson, Peder and Nielsen, Niels Eric and Christersson, Christina and Johansson, Bengt},
  issn         = {0167-5273},
  keyword      = {Adult congenital heart disease,CoA,Hypertension,Left ventricular hypertrophy},
  language     = {eng},
  month        = {09},
  pages        = {59--64},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; Association with systolic blood pressure in the high normal range},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2016.05.033},
  volume       = {218},
  year         = {2016},
}