Risk factors for incident asthma and COPD in a cohort of young adults
(2018) In Clinical Respiratory Journal 12(3). p.1021-1029- Abstract
Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in... (More)
Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1<100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1<100% predicted (all male cases had FEV1<100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.
(Less)
- author
- Traulsen, Lisbet Krogh ; Bælum, Jesper ; Halling, Anders LU ; Thomsen, Gert ; Thilsing, Trine ; Sherson, David ; Sigsgaard, Torben ; Omland, Øyvind ; Malling, Tine and Skadhauge, Lars Rauff
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Asthma, Cohort study, COPD, Epidemiology, Risk factor
- in
- Clinical Respiratory Journal
- volume
- 12
- issue
- 3
- pages
- 1021 - 1029
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:28268257
- scopus:85016999975
- ISSN
- 1752-6981
- DOI
- 10.1111/crj.12622
- language
- English
- LU publication?
- yes
- id
- 8f1427d6-60d1-4de6-bc72-d7135dccee6f
- date added to LUP
- 2017-05-16 09:28:38
- date last changed
- 2024-08-18 21:55:17
@article{8f1427d6-60d1-4de6-bc72-d7135dccee6f, abstract = {{<p>Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV<sub>1</sub><100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV<sub>1</sub><100% predicted (all male cases had FEV<sub>1</sub><100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.</p>}}, author = {{Traulsen, Lisbet Krogh and Bælum, Jesper and Halling, Anders and Thomsen, Gert and Thilsing, Trine and Sherson, David and Sigsgaard, Torben and Omland, Øyvind and Malling, Tine and Skadhauge, Lars Rauff}}, issn = {{1752-6981}}, keywords = {{Adult; Asthma; Cohort study; COPD; Epidemiology; Risk factor}}, language = {{eng}}, number = {{3}}, pages = {{1021--1029}}, publisher = {{Wiley-Blackwell}}, series = {{Clinical Respiratory Journal}}, title = {{Risk factors for incident asthma and COPD in a cohort of young adults}}, url = {{http://dx.doi.org/10.1111/crj.12622}}, doi = {{10.1111/crj.12622}}, volume = {{12}}, year = {{2018}}, }