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Risk factors for incident asthma and COPD in a cohort of young adults

Traulsen, Lisbet Krogh; Bælum, Jesper; Halling, Anders LU ; Thomsen, Gert; Thilsing, Trine; Sherson, David; Sigsgaard, Torben; Omland, Øyvind; Malling, Tine and Skadhauge, Lars Rauff (2017) In Clinical Respiratory Journal
Abstract

Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in... (More)

Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1<100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1<100% predicted (all male cases had FEV1<100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Adult, Asthma, Cohort study, COPD, Epidemiology, Risk factor
in
Clinical Respiratory Journal
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85016999975
ISSN
1752-6981
DOI
10.1111/crj.12622
language
English
LU publication?
yes
id
8f1427d6-60d1-4de6-bc72-d7135dccee6f
date added to LUP
2017-05-16 09:28:38
date last changed
2018-01-07 12:03:35
@article{8f1427d6-60d1-4de6-bc72-d7135dccee6f,
  abstract     = {<p>Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV<sub>1</sub>&lt;100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV<sub>1</sub>&lt;100% predicted (all male cases had FEV<sub>1</sub>&lt;100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.</p>},
  author       = {Traulsen, Lisbet Krogh and Bælum, Jesper and Halling, Anders and Thomsen, Gert and Thilsing, Trine and Sherson, David and Sigsgaard, Torben and Omland, Øyvind and Malling, Tine and Skadhauge, Lars Rauff},
  issn         = {1752-6981},
  keyword      = {Adult,Asthma,Cohort study,COPD,Epidemiology,Risk factor},
  language     = {eng},
  pages        = {9},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Respiratory Journal},
  title        = {Risk factors for incident asthma and COPD in a cohort of young adults},
  url          = {http://dx.doi.org/10.1111/crj.12622},
  year         = {2017},
}