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Risk factors for incident asthma and COPD in a cohort of young adults

Traulsen, Lisbet Krogh ; Bælum, Jesper ; Halling, Anders LU ; Thomsen, Gert ; Thilsing, Trine ; Sherson, David ; Sigsgaard, Torben ; Omland, Øyvind ; Malling, Tine and Skadhauge, Lars Rauff (2018) In Clinical Respiratory Journal 12(3). p.1021-1029
Abstract

Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in... (More)

Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1<100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1<100% predicted (all male cases had FEV1<100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Asthma, Cohort study, COPD, Epidemiology, Risk factor
in
Clinical Respiratory Journal
volume
12
issue
3
pages
1021 - 1029
publisher
Wiley-Blackwell
external identifiers
  • scopus:85016999975
  • pmid:28268257
ISSN
1752-6981
DOI
10.1111/crj.12622
language
English
LU publication?
yes
id
8f1427d6-60d1-4de6-bc72-d7135dccee6f
date added to LUP
2017-05-16 09:28:38
date last changed
2024-04-28 12:34:10
@article{8f1427d6-60d1-4de6-bc72-d7135dccee6f,
  abstract     = {{<p>Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV<sub>1</sub>&lt;100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV<sub>1</sub>&lt;100% predicted (all male cases had FEV<sub>1</sub>&lt;100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.</p>}},
  author       = {{Traulsen, Lisbet Krogh and Bælum, Jesper and Halling, Anders and Thomsen, Gert and Thilsing, Trine and Sherson, David and Sigsgaard, Torben and Omland, Øyvind and Malling, Tine and Skadhauge, Lars Rauff}},
  issn         = {{1752-6981}},
  keywords     = {{Adult; Asthma; Cohort study; COPD; Epidemiology; Risk factor}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1021--1029}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Clinical Respiratory Journal}},
  title        = {{Risk factors for incident asthma and COPD in a cohort of young adults}},
  url          = {{http://dx.doi.org/10.1111/crj.12622}},
  doi          = {{10.1111/crj.12622}},
  volume       = {{12}},
  year         = {{2018}},
}