Advanced

The hippocampus in families with schizophrenia in relation to obstetric complications

Ebner, Florian LU ; Tepest, Ralf ; Dani, Indra ; Pfeiffer, Ute ; Schulze, Thomas G. ; Rietschel, Marcella ; Maier, Wolfgang ; Träber, Frank ; Block, Wolfgang and Schild, Hans H. , et al. (2008) In Schizophrenia Research 104(1-3). p.71-78
Abstract

Background: Hippocampal volume reduction is a well replicated finding in schizophrenia. Evidence indicates a contribution of genetic and environmental factors, especially the influence of obstetric complications to this volume reduction. The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications. Methods: T1 weighted MRI brain scans of 50 schizophrenic patients, 88 first-degree relatives and 53 healthy control subjects were used to perform volumetric measurements on the left and right hippocampus. A set of clinical measures including obstetric complications were recorded for all family... (More)

Background: Hippocampal volume reduction is a well replicated finding in schizophrenia. Evidence indicates a contribution of genetic and environmental factors, especially the influence of obstetric complications to this volume reduction. The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications. Methods: T1 weighted MRI brain scans of 50 schizophrenic patients, 88 first-degree relatives and 53 healthy control subjects were used to perform volumetric measurements on the left and right hippocampus. A set of clinical measures including obstetric complications were recorded for all family members. Results: Numerically our measurements revealed a hippocampal volume reduction in schizophrenic patients (left: - 14%, right: - 15%) and, although less pronounced, in their unaffected relatives (left: - 6%, right: - 10%). Noted differences in hippocampal volume between schizophrenic patients and controls were only significant for the left side. Hippocampal volumes of patients and their relatives with obstetric complications were reduced bilaterally. Conclusions: Hippocampal volume reduction is present in schizophrenic patients and their first-degree relatives, suggesting an influence of genetic factors.. In addition, however, obstetric complications have also been shown to play a major role.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Family study, Hippocampus, MRI, Obstetric complications, Schizophrenia
in
Schizophrenia Research
volume
104
issue
1-3
pages
8 pages
publisher
Elsevier
external identifiers
  • pmid:18656329
  • scopus:50249125306
ISSN
0920-9964
DOI
10.1016/j.schres.2008.06.007
language
English
LU publication?
no
id
8f202611-4dfe-4799-a8c8-1ce8c2bf61d1
date added to LUP
2019-10-15 15:29:25
date last changed
2020-01-13 02:27:45
@article{8f202611-4dfe-4799-a8c8-1ce8c2bf61d1,
  abstract     = {<p>Background: Hippocampal volume reduction is a well replicated finding in schizophrenia. Evidence indicates a contribution of genetic and environmental factors, especially the influence of obstetric complications to this volume reduction. The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications. Methods: T1 weighted MRI brain scans of 50 schizophrenic patients, 88 first-degree relatives and 53 healthy control subjects were used to perform volumetric measurements on the left and right hippocampus. A set of clinical measures including obstetric complications were recorded for all family members. Results: Numerically our measurements revealed a hippocampal volume reduction in schizophrenic patients (left: - 14%, right: - 15%) and, although less pronounced, in their unaffected relatives (left: - 6%, right: - 10%). Noted differences in hippocampal volume between schizophrenic patients and controls were only significant for the left side. Hippocampal volumes of patients and their relatives with obstetric complications were reduced bilaterally. Conclusions: Hippocampal volume reduction is present in schizophrenic patients and their first-degree relatives, suggesting an influence of genetic factors.. In addition, however, obstetric complications have also been shown to play a major role.</p>},
  author       = {Ebner, Florian and Tepest, Ralf and Dani, Indra and Pfeiffer, Ute and Schulze, Thomas G. and Rietschel, Marcella and Maier, Wolfgang and Träber, Frank and Block, Wolfgang and Schild, Hans H. and Wagner, Michael and Steinmetz, Helmuth and Gaebel, Wolfgang and Honer, William G. and Schneider-Axmann, Thomas and Falkai, Peter},
  issn         = {0920-9964},
  language     = {eng},
  month        = {09},
  number       = {1-3},
  pages        = {71--78},
  publisher    = {Elsevier},
  series       = {Schizophrenia Research},
  title        = {The hippocampus in families with schizophrenia in relation to obstetric complications},
  url          = {http://dx.doi.org/10.1016/j.schres.2008.06.007},
  doi          = {10.1016/j.schres.2008.06.007},
  volume       = {104},
  year         = {2008},
}