The heritability of doctor-diagnosed traumatic and degenerative meniscus tears
Magnusson, K. LU ; Turkiewicz, A. LU ; Snoeker, B. LU ; Hughes, V. LU and Englund, M. LU
(2021)
In Osteoarthritis and Cartilage
29(7).
p.979-985
- Abstract
Objective: To estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan. Methods: We linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years. Results: During follow-up, 3,372 (3.8%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear. The heritability was 0.39 (95% CI = 0.32–0.47) for men and 0.43 (95% CI = 0.36–0.50) for women, and did... (More)
Objective: To estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan. Methods: We linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years. Results: During follow-up, 3,372 (3.8%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear. The heritability was 0.39 (95% CI = 0.32–0.47) for men and 0.43 (95% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95% CI = 0.53–0.68) and women (0.57, 95% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results. Conclusion: For the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.
(Less)
- author
- Magnusson, K.
LU
; Turkiewicz, A.
LU
; Snoeker, B.
LU
; Hughes, V.
LU
and Englund, M.
LU
- organization
- publishing date
- 2021-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute meniscus tears, Degenerative meniscus tears, Epidemiology, Genetics, Meniscus tears
- in
- Osteoarthritis and Cartilage
- volume
- 29
- issue
- 7
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85104068432
- pmid:33744431
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2021.03.005
- language
- English
- LU publication?
- yes
- id
- 8f2a4522-0b8c-4df6-9912-4f4263498955
- date added to LUP
- 2021-04-21 08:58:41
- date last changed
- 2024-04-20 05:08:24
@article{8f2a4522-0b8c-4df6-9912-4f4263498955,
abstract = {{<p>Objective: To estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan. Methods: We linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years. Results: During follow-up, 3,372 (3.8%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear. The heritability was 0.39 (95% CI = 0.32–0.47) for men and 0.43 (95% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95% CI = 0.53–0.68) and women (0.57, 95% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results. Conclusion: For the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.</p>}},
author = {{Magnusson, K. and Turkiewicz, A. and Snoeker, B. and Hughes, V. and Englund, M.}},
issn = {{1063-4584}},
keywords = {{Acute meniscus tears; Degenerative meniscus tears; Epidemiology; Genetics; Meniscus tears}},
language = {{eng}},
month = {{07}},
number = {{7}},
pages = {{979--985}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage}},
title = {{The heritability of doctor-diagnosed traumatic and degenerative meniscus tears}},
url = {{http://dx.doi.org/10.1016/j.joca.2021.03.005}},
doi = {{10.1016/j.joca.2021.03.005}},
volume = {{29}},
year = {{2021}},
}