Plasma cotinine levels and pancreatic cancer in the EPIC cohort study
(2012) In International Journal of Cancer 131(4). p.997-1002- Abstract
- Smoking is an established risk factor for pancreatic cancer, previously investigated by the means of questionnaires. Using cotinine as a biomarker for tobacco exposure allows more accurate quantitative analyses to be performed. This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. Using liquid chromatography-mass spectrometry, plasma cotinine levels were analyzed on average 8.0 years before cancer onset (595% range: 2.812.0 years). The relation between plasma cotinine levels and pancreatic cancer was analyzed with conditional logistic regression for different levels of cotinine in a population of never and current smokers.... (More)
- Smoking is an established risk factor for pancreatic cancer, previously investigated by the means of questionnaires. Using cotinine as a biomarker for tobacco exposure allows more accurate quantitative analyses to be performed. This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. Using liquid chromatography-mass spectrometry, plasma cotinine levels were analyzed on average 8.0 years before cancer onset (595% range: 2.812.0 years). The relation between plasma cotinine levels and pancreatic cancer was analyzed with conditional logistic regression for different levels of cotinine in a population of never and current smokers. This was also done for the self-reported number of smoked cigarettes per day at baseline. Every increase of 350 nmol/L of plasma cotinine was found to significantly elevate risk of pancreatic cancer [odds ratio (OR): 1.33, 95% confidence interval (CI): 1.111.60]. People with a cotinine level over 1187.8 nmol/L, a level comparable to smoking 17 cigarettes per day, have an elevated risk of pancreatic cancer, compared to people with cotinine levels below 55 nmol/L (OR: 3.66, 95% CI: 1.449.26). The results for self-reported smoking at baseline also show an increased risk of pancreatic cancer from cigarette smoking based on questionnaire information. People who smoke more than 30 cigarettes per day showed the highest risk compared to never smokers (OR: 4.15, 95% CI: 1.0216.42). This study is the first to show that plasma cotinine levels are strongly related to pancreatic cancer. (Less)
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https://lup.lub.lu.se/record/2863493
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- EPIC, smoking, cotinine, pancreatic cancer
- in
- International Journal of Cancer
- volume
- 131
- issue
- 4
- pages
- 997 - 1002
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000305451300051
- scopus:84862520823
- pmid:21953524
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.26452
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- 8f2febfd-262a-4715-b5ff-1245200d4f81 (old id 2863493)
- date added to LUP
- 2016-04-01 09:59:19
- date last changed
- 2022-05-05 17:34:18
@article{8f2febfd-262a-4715-b5ff-1245200d4f81,
abstract = {{Smoking is an established risk factor for pancreatic cancer, previously investigated by the means of questionnaires. Using cotinine as a biomarker for tobacco exposure allows more accurate quantitative analyses to be performed. This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. Using liquid chromatography-mass spectrometry, plasma cotinine levels were analyzed on average 8.0 years before cancer onset (595% range: 2.812.0 years). The relation between plasma cotinine levels and pancreatic cancer was analyzed with conditional logistic regression for different levels of cotinine in a population of never and current smokers. This was also done for the self-reported number of smoked cigarettes per day at baseline. Every increase of 350 nmol/L of plasma cotinine was found to significantly elevate risk of pancreatic cancer [odds ratio (OR): 1.33, 95% confidence interval (CI): 1.111.60]. People with a cotinine level over 1187.8 nmol/L, a level comparable to smoking 17 cigarettes per day, have an elevated risk of pancreatic cancer, compared to people with cotinine levels below 55 nmol/L (OR: 3.66, 95% CI: 1.449.26). The results for self-reported smoking at baseline also show an increased risk of pancreatic cancer from cigarette smoking based on questionnaire information. People who smoke more than 30 cigarettes per day showed the highest risk compared to never smokers (OR: 4.15, 95% CI: 1.0216.42). This study is the first to show that plasma cotinine levels are strongly related to pancreatic cancer.}},
author = {{Leenders, Max and Chuang, Shu-Chun and Dahm, Christina C. and Overvad, Kim and Ueland, Per Magne and Midttun, Oivind and Vollset, Stein Emil and Tjonneland, Anne and Halkjaer, Jytte and Jenab, Mazda and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Kaaks, Rudolf and Canzian, Federico and Boeing, Heiner and Weikert, Cornelia and Trichopoulou, Antonia and Bamia, Christina and Naska, Androniki and Palli, Domenico and Pala, Valeria and Mattiello, Amalia and Tumino, Rosario and Sacerdote, Carlotta and van Duijnhoven, Franzel J. B. and Peeters, Petra H. M. and van Gils, Carla H. and Lund, Eiliv and Rodriguez, Laudina and Duell, Eric J. and Sanchez Perez, Maria-Jose and Molina-Montes, Esther and Huerta Castano, Jose Maria and Barricarte, Aurelio and Larranaga, Nerea and Johansen, Dorthe and Lindkvist, Bjorn and Sund, Malin and Ye, Weimin and Khaw, Kay-Tee and Wareham, Nicholas J. and Michaud, Dominique S. and Riboli, Elio and Xun, Wei W. and Allen, Naomi E. and Crowe, Francesca L. and Bueno-de-Mesquita, H. Bas and Vineis, Paolo}},
issn = {{0020-7136}},
keywords = {{EPIC; smoking; cotinine; pancreatic cancer}},
language = {{eng}},
number = {{4}},
pages = {{997--1002}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Plasma cotinine levels and pancreatic cancer in the EPIC cohort study}},
url = {{http://dx.doi.org/10.1002/ijc.26452}},
doi = {{10.1002/ijc.26452}},
volume = {{131}},
year = {{2012}},
}