Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Hip dysplasia as risk factor for clinically relevant and radiographic hip osteoarthritis : 10-year results from the CHECK cohort

Vinge, Rebecka LU orcid ; Riedstra, Noortje ; Tiderius, Carl Johan LU ; Bierma-Zeinstra, Sita ; Agricola, Rintje LU and Runhaar, Jos (2025) In Rheumatology (Oxford, England) 64(1). p.149-155
Abstract

OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.

METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade <2) at baseline, as well as available follow-up measures. Clinically relevant hip OA was defined by an expert diagnosis based on clinical and radiographic data obtained between years 5 and 10 from baseline. Incident radiographic hip OA was defined by KL grade ≥2 or a total hip replacement at the 10-year follow-up. Associations... (More)

OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.

METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade <2) at baseline, as well as available follow-up measures. Clinically relevant hip OA was defined by an expert diagnosis based on clinical and radiographic data obtained between years 5 and 10 from baseline. Incident radiographic hip OA was defined by KL grade ≥2 or a total hip replacement at the 10-year follow-up. Associations between hip dysplasia (LCEA ≤20°) and outcomes were expressed as an odds ratio (OR) adjusted for age, sex and BMI.

RESULTS: At baseline, participants had a mean age of 55.5 (5.4) years, 88% were female and, on hip level, the prevalence of hip dysplasia was 3.6% (n = 17). After 10 years, hip dysplasia was associated with an increased risk for clinically relevant hip OA (OR 2.80; 95% CI: 1.15, 6.79), but not for incident radiographic hip OA (OR 0.78; 95% CI: 0.26, 2.30).

CONCLUSION: In the long term, baseline hip dysplasia was associated with an increased risk for clinically relevant hip OA, but not for incident radiographic hip OA. With this in mind, we suggest that future research investigating the link between hip dysplasia and OA strives to include a definition for OA that is clinically relevant.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Female, Male, Osteoarthritis, Hip/diagnostic imaging, Middle Aged, Risk Factors, Radiography, Prospective Studies, Hip Dislocation/diagnostic imaging, Arthroplasty, Replacement, Hip, Incidence, Prevalence, Hip Joint/diagnostic imaging, Follow-Up Studies
in
Rheumatology (Oxford, England)
volume
64
issue
1
pages
149 - 155
publisher
Oxford University Press
external identifiers
  • pmid:38059608
  • scopus:85195837540
ISSN
1462-0332
DOI
10.1093/rheumatology/kead650
language
English
LU publication?
yes
additional info
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
id
8f392f96-0684-4c07-9d81-e5b0fd5c4265
date added to LUP
2025-07-16 14:12:06
date last changed
2025-07-17 15:41:49
@article{8f392f96-0684-4c07-9d81-e5b0fd5c4265,
  abstract     = {{<p>OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.</p><p>METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade &lt;2) at baseline, as well as available follow-up measures. Clinically relevant hip OA was defined by an expert diagnosis based on clinical and radiographic data obtained between years 5 and 10 from baseline. Incident radiographic hip OA was defined by KL grade ≥2 or a total hip replacement at the 10-year follow-up. Associations between hip dysplasia (LCEA ≤20°) and outcomes were expressed as an odds ratio (OR) adjusted for age, sex and BMI.</p><p>RESULTS: At baseline, participants had a mean age of 55.5 (5.4) years, 88% were female and, on hip level, the prevalence of hip dysplasia was 3.6% (n = 17). After 10 years, hip dysplasia was associated with an increased risk for clinically relevant hip OA (OR 2.80; 95% CI: 1.15, 6.79), but not for incident radiographic hip OA (OR 0.78; 95% CI: 0.26, 2.30).</p><p>CONCLUSION: In the long term, baseline hip dysplasia was associated with an increased risk for clinically relevant hip OA, but not for incident radiographic hip OA. With this in mind, we suggest that future research investigating the link between hip dysplasia and OA strives to include a definition for OA that is clinically relevant.</p>}},
  author       = {{Vinge, Rebecka and Riedstra, Noortje and Tiderius, Carl Johan and Bierma-Zeinstra, Sita and Agricola, Rintje and Runhaar, Jos}},
  issn         = {{1462-0332}},
  keywords     = {{Humans; Female; Male; Osteoarthritis, Hip/diagnostic imaging; Middle Aged; Risk Factors; Radiography; Prospective Studies; Hip Dislocation/diagnostic imaging; Arthroplasty, Replacement, Hip; Incidence; Prevalence; Hip Joint/diagnostic imaging; Follow-Up Studies}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{149--155}},
  publisher    = {{Oxford University Press}},
  series       = {{Rheumatology (Oxford, England)}},
  title        = {{Hip dysplasia as risk factor for clinically relevant and radiographic hip osteoarthritis : 10-year results from the CHECK cohort}},
  url          = {{http://dx.doi.org/10.1093/rheumatology/kead650}},
  doi          = {{10.1093/rheumatology/kead650}},
  volume       = {{64}},
  year         = {{2025}},
}