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Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease

Chen, Qian Qian ; Haikal, Caroline LU ; Li, Wen LU and Li, Jia Yi LU (2019) In Frontiers in Molecular Neuroscience 12.
Abstract

Parkinson’s disease (PD) is a neurodegenerative disease that is generally thought to be caused by multiple factors, including environmental and genetic factors. Emerging evidence suggests that intestinal disturbances, such as constipation, are common non-motor symptoms of PD. Gut inflammation may be closely associated with pathogenesis in PD. This review aims to discuss the cross-talk between gut inflammation and PD pathology initiation and progression. Firstly, we will highlight the studies demonstrating how gut inflammation is related to PD. Secondly, we will analyze how gut inflammation spreads from the gastro-intestine to the brain. Here, we will mainly discuss the neural pathway of pathologic α-syn and the systemic inflammatory... (More)

Parkinson’s disease (PD) is a neurodegenerative disease that is generally thought to be caused by multiple factors, including environmental and genetic factors. Emerging evidence suggests that intestinal disturbances, such as constipation, are common non-motor symptoms of PD. Gut inflammation may be closely associated with pathogenesis in PD. This review aims to discuss the cross-talk between gut inflammation and PD pathology initiation and progression. Firstly, we will highlight the studies demonstrating how gut inflammation is related to PD. Secondly, we will analyze how gut inflammation spreads from the gastro-intestine to the brain. Here, we will mainly discuss the neural pathway of pathologic α-syn and the systemic inflammatory routes. Thereafter, we will address how alterations in the brain subsequently lead to dopaminergic neuron degeneration, in which oxidative stress, glutamate excitotoxicity, T cell driven inflammation and cyclooxygenase-2 (COX-2) are involved. We conclude a model of PD triggered by gut inflammation, which provides a new angle to understand the mechanisms of the disease.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cyclooxygenase-2, glutamate excitotoxicity, gut inflammation, oxidative stress, Parkinson’s disease, T-cell, α-synuclein
in
Frontiers in Molecular Neuroscience
volume
12
article number
218
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85072886600
  • pmid:31572126
ISSN
1662-5099
DOI
10.3389/fnmol.2019.00218
language
English
LU publication?
yes
id
8f3b529b-bf53-4b84-93e2-5339c7236bf7
date added to LUP
2019-10-16 14:46:48
date last changed
2024-06-13 05:39:32
@article{8f3b529b-bf53-4b84-93e2-5339c7236bf7,
  abstract     = {{<p>Parkinson’s disease (PD) is a neurodegenerative disease that is generally thought to be caused by multiple factors, including environmental and genetic factors. Emerging evidence suggests that intestinal disturbances, such as constipation, are common non-motor symptoms of PD. Gut inflammation may be closely associated with pathogenesis in PD. This review aims to discuss the cross-talk between gut inflammation and PD pathology initiation and progression. Firstly, we will highlight the studies demonstrating how gut inflammation is related to PD. Secondly, we will analyze how gut inflammation spreads from the gastro-intestine to the brain. Here, we will mainly discuss the neural pathway of pathologic α-syn and the systemic inflammatory routes. Thereafter, we will address how alterations in the brain subsequently lead to dopaminergic neuron degeneration, in which oxidative stress, glutamate excitotoxicity, T cell driven inflammation and cyclooxygenase-2 (COX-2) are involved. We conclude a model of PD triggered by gut inflammation, which provides a new angle to understand the mechanisms of the disease.</p>}},
  author       = {{Chen, Qian Qian and Haikal, Caroline and Li, Wen and Li, Jia Yi}},
  issn         = {{1662-5099}},
  keywords     = {{cyclooxygenase-2; glutamate excitotoxicity; gut inflammation; oxidative stress; Parkinson’s disease; T-cell; α-synuclein}},
  language     = {{eng}},
  month        = {{09}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Molecular Neuroscience}},
  title        = {{Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease}},
  url          = {{http://dx.doi.org/10.3389/fnmol.2019.00218}},
  doi          = {{10.3389/fnmol.2019.00218}},
  volume       = {{12}},
  year         = {{2019}},
}