Joint Modeling of Singleton Preterm Birth and Perinatal Death Using Birth Registry Cohort Data in Northern Tanzania
Mboya, Innocent B. LU
; Mahande, Michael J.
; Obure, Joseph
and Mwambi, Henry G.
(2021)
In Frontiers in Pediatrics
9.
- Abstract
Understanding independent and joint predictors of adverse pregnancy outcomes is essential to inform interventions toward achieving sustainable development goals. We aimed to determine the joint predictors of preterm birth and perinatal death among singleton births in northern Tanzania based on cohort data from the Kilimanjaro Christian Medical Center (KCMC) zonal referral hospital birth registry between 2000 and 2017. We determined the joint predictors of preterm birth and perinatal death using the random-effects models to account for the correlation between these outcomes. The joint predictors of higher preterm birth and perinatal death risk were inadequate (<4) antenatal care (ANC) visits, referred for delivery, experiencing... (More)
Understanding independent and joint predictors of adverse pregnancy outcomes is essential to inform interventions toward achieving sustainable development goals. We aimed to determine the joint predictors of preterm birth and perinatal death among singleton births in northern Tanzania based on cohort data from the Kilimanjaro Christian Medical Center (KCMC) zonal referral hospital birth registry between 2000 and 2017. We determined the joint predictors of preterm birth and perinatal death using the random-effects models to account for the correlation between these outcomes. The joint predictors of higher preterm birth and perinatal death risk were inadequate (<4) antenatal care (ANC) visits, referred for delivery, experiencing pre-eclampsia/eclampsia, postpartum hemorrhage, low birth weight, abruption placenta, and breech presentation. Younger maternal age (15–24 years), premature rupture of membranes, placenta previa, and male children had higher odds of preterm birth but a lessened likelihood of perinatal death. These findings suggest ANC is a critical entry point for delivering the recommended interventions to pregnant women, especially those at high risk of experiencing adverse pregnancy outcomes. Improved management of complications during pregnancy and childbirth and the postnatal period may eventually lead to a substantial reduction of adverse perinatal outcomes and improving maternal and child health.
(Less)
- author
- Mboya, Innocent B.
LU
; Mahande, Michael J.
; Obure, Joseph
and Mwambi, Henry G.
- publishing date
- 2021-11-30
- type
- Contribution to journal
- publication status
- published
- keywords
- adverse perinatal outcomes, bivariate binary outcomes, joint modeling, perinatal death, preterm birth, sub-Saharan Africa
- in
- Frontiers in Pediatrics
- volume
- 9
- article number
- 749707
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85121206384
- pmid:34917558
- ISSN
- 2296-2360
- DOI
- 10.3389/fped.2021.749707
- language
- English
- LU publication?
- no
- additional info
- Funding Information: This work was funded by GSK Africa Non-Communicable Disease Open Lab through the DELTAS Africa Sub-Saharan African Consortium for Advanced Biostatistics (SSACAB) Grant No. 107754/Z/15/Z-training programme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed in this publication are those of the author(s) and not necessarily those of GSK. Publisher Copyright: Copyright © 2021 Mboya, Mahande, Obure and Mwambi.
- id
- 8f3f3cc6-4da9-4136-9b45-4f0d4e79cfb5
- date added to LUP
- 2022-09-29 10:03:03
- date last changed
- 2024-05-30 18:51:28
@article{8f3f3cc6-4da9-4136-9b45-4f0d4e79cfb5,
abstract = {{<p>Understanding independent and joint predictors of adverse pregnancy outcomes is essential to inform interventions toward achieving sustainable development goals. We aimed to determine the joint predictors of preterm birth and perinatal death among singleton births in northern Tanzania based on cohort data from the Kilimanjaro Christian Medical Center (KCMC) zonal referral hospital birth registry between 2000 and 2017. We determined the joint predictors of preterm birth and perinatal death using the random-effects models to account for the correlation between these outcomes. The joint predictors of higher preterm birth and perinatal death risk were inadequate (<4) antenatal care (ANC) visits, referred for delivery, experiencing pre-eclampsia/eclampsia, postpartum hemorrhage, low birth weight, abruption placenta, and breech presentation. Younger maternal age (15–24 years), premature rupture of membranes, placenta previa, and male children had higher odds of preterm birth but a lessened likelihood of perinatal death. These findings suggest ANC is a critical entry point for delivering the recommended interventions to pregnant women, especially those at high risk of experiencing adverse pregnancy outcomes. Improved management of complications during pregnancy and childbirth and the postnatal period may eventually lead to a substantial reduction of adverse perinatal outcomes and improving maternal and child health.</p>}},
author = {{Mboya, Innocent B. and Mahande, Michael J. and Obure, Joseph and Mwambi, Henry G.}},
issn = {{2296-2360}},
keywords = {{adverse perinatal outcomes; bivariate binary outcomes; joint modeling; perinatal death; preterm birth; sub-Saharan Africa}},
language = {{eng}},
month = {{11}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Pediatrics}},
title = {{Joint Modeling of Singleton Preterm Birth and Perinatal Death Using Birth Registry Cohort Data in Northern Tanzania}},
url = {{http://dx.doi.org/10.3389/fped.2021.749707}},
doi = {{10.3389/fped.2021.749707}},
volume = {{9}},
year = {{2021}},
}