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Reliability of the point-of care analyzer “StatStrip® Xpress™” for measurement of fetal blood lactate

Iorizzo, Linda LU ; Persson, Kristina E.M. LU ; Kristensen, Karl H. LU and Wiberg, Nana LU orcid (2019) In Clinica Chimica Acta 495. p.88-93
Abstract


Objectives: Measurement of lactate in fetal blood is used to assess the degree of anaerobic metabolism. The technical difficulties in obtaining enough scalp blood for analysis by a bloodgas-analyzer advocates for the use of a point-of-care device. StatStrip®Xpress™ (SSX) has shown promising properties but needs further evaluation before implementation into fetal surveillance. Methods: Arterial/venous umbilical cord blood from 112 newborns were analyzed simultaneously with SSX and the reference method ABL800™. From 321 fetuses with abnormal heart rate scalp blood was sampled and analyzed repeatedly with SSX. Results: ABL800™ -lactate ranged from 1.9–13.3 mmol/L in arterial to... (More)


Objectives: Measurement of lactate in fetal blood is used to assess the degree of anaerobic metabolism. The technical difficulties in obtaining enough scalp blood for analysis by a bloodgas-analyzer advocates for the use of a point-of-care device. StatStrip®Xpress™ (SSX) has shown promising properties but needs further evaluation before implementation into fetal surveillance. Methods: Arterial/venous umbilical cord blood from 112 newborns were analyzed simultaneously with SSX and the reference method ABL800™. From 321 fetuses with abnormal heart rate scalp blood was sampled and analyzed repeatedly with SSX. Results: ABL800™ -lactate ranged from 1.9–13.3 mmol/L in arterial to 1.5–10.2 mmol/L in venous cord blood with excellent correlation to SSX (R
2
= 0.95). SSX-values were lower compared to the reference method ranging from −0.79 mmol/L for low values to −1.68 mmol/L for high values. The mean CV for SSX-values in cord respectively scalp blood was: lactate ≤3 mmol/L 7.1% respectively 8.4%; lactate >3 mmol/L 3.8% respectively 6.8%. Repeated measurements of the same sample with SSX where without significant difference in cord/scalp blood (p = 0.11). Conclusion: SSX-lactate values were constantly lower but correlated excellent to the reference method. The reproducibility was good for cord and scalp blood. We suggest SSX as an attractive device for measurement of fetal lactate.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Analytical performance, Blood gas analysis, Fetal blood, Fetal surveillance, Lactate, Point-of-care device
in
Clinica Chimica Acta
volume
495
pages
6 pages
publisher
Elsevier
external identifiers
  • pmid:30953612
  • scopus:85063967928
ISSN
0009-8981
DOI
10.1016/j.cca.2019.04.003
language
English
LU publication?
yes
id
8f538717-f447-48c3-ac60-dae531e6bf27
date added to LUP
2019-04-24 11:09:46
date last changed
2024-08-20 14:27:17
@article{8f538717-f447-48c3-ac60-dae531e6bf27,
  abstract     = {{<p><br>
                                                         Objectives: Measurement of lactate in fetal blood is used to assess the degree of anaerobic metabolism. The technical difficulties in obtaining enough scalp blood for analysis by a bloodgas-analyzer advocates for the use of a point-of-care device. StatStrip®Xpress™ (SSX) has shown promising properties but needs further evaluation before implementation into fetal surveillance. Methods: Arterial/venous umbilical cord blood from 112 newborns were analyzed simultaneously with SSX and the reference method ABL800™. From 321 fetuses with abnormal heart rate scalp blood was sampled and analyzed repeatedly with SSX. Results: ABL800™ -lactate ranged from 1.9–13.3 mmol/L in arterial to 1.5–10.2 mmol/L in venous cord blood with excellent correlation to SSX (R                             <br>
                            <sup>2</sup><br>
                                                          = 0.95). SSX-values were lower compared to the reference method ranging from −0.79 mmol/L for low values to −1.68 mmol/L for high values. The mean CV for SSX-values in cord respectively scalp blood was: lactate ≤3 mmol/L 7.1% respectively 8.4%; lactate &gt;3 mmol/L 3.8% respectively 6.8%. Repeated measurements of the same sample with SSX where without significant difference in cord/scalp blood (p = 0.11). Conclusion: SSX-lactate values were constantly lower but correlated excellent to the reference method. The reproducibility was good for cord and scalp blood. We suggest SSX as an attractive device for measurement of fetal lactate.                         <br>
                        </p>}},
  author       = {{Iorizzo, Linda and Persson, Kristina E.M. and Kristensen, Karl H. and Wiberg, Nana}},
  issn         = {{0009-8981}},
  keywords     = {{Analytical performance; Blood gas analysis; Fetal blood; Fetal surveillance; Lactate; Point-of-care device}},
  language     = {{eng}},
  pages        = {{88--93}},
  publisher    = {{Elsevier}},
  series       = {{Clinica Chimica Acta}},
  title        = {{Reliability of the point-of care analyzer “StatStrip® Xpress™” for measurement of fetal blood lactate}},
  url          = {{http://dx.doi.org/10.1016/j.cca.2019.04.003}},
  doi          = {{10.1016/j.cca.2019.04.003}},
  volume       = {{495}},
  year         = {{2019}},
}