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Preanalytical confounding factors in the analysis of cerebrospinal fluid biomarkers for Alzheimer's disease : The issue of diurnal variation

Cicognola, Claudia LU orcid ; Chiasserini, Davide and Parnetti, Lucilla (2015) In Frontiers in Neurology 6(JUN).
Abstract

Given the growing use of cerebrospinal fluid (CSF) beta-amyloid (Aß) and tau as biomarkers for early diagnosis of Alzheimer's disease (AD), it is essential that the diagnostic procedures are standardized and the results comparable across different laboratories. Preanalytical factors are reported to be the cause of at least 50% of the total variability. Among them, diurnal variability is a key issue and may have an impact on the comparability of the values obtained. The available studies on this issue are not conclusive so far. Fluctuations of CSF biomarkers in young healthy volunteers have been previously reported, while subsequent studies have not confirmed those observations in older subjects, the ones most likely to receive this... (More)

Given the growing use of cerebrospinal fluid (CSF) beta-amyloid (Aß) and tau as biomarkers for early diagnosis of Alzheimer's disease (AD), it is essential that the diagnostic procedures are standardized and the results comparable across different laboratories. Preanalytical factors are reported to be the cause of at least 50% of the total variability. Among them, diurnal variability is a key issue and may have an impact on the comparability of the values obtained. The available studies on this issue are not conclusive so far. Fluctuations of CSF biomarkers in young healthy volunteers have been previously reported, while subsequent studies have not confirmed those observations in older subjects, the ones most likely to receive this test. The observed differences in circadian rhythms need to be further assessed not only in classical CSF biomarkers but also in novel forthcoming biomarkers. In this review, the existing data on the issue of diurnal variations of CSF classical biomarkers for AD will be analyzed, also evaluating the available data on new possible biomarkers.

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Biomarkers, Cerebrospinal fluid, Circadian rhythm, Confounding factors, Diurnal variability
in
Frontiers in Neurology
volume
6
issue
JUN
article number
143
publisher
Frontiers Media S. A.
external identifiers
  • scopus:84936941824
ISSN
1664-2295
DOI
10.3389/fneur.2015.00143
language
English
LU publication?
no
id
8f6ab918-16ee-423c-9a0a-75983ec3ba8d
date added to LUP
2020-02-25 09:51:07
date last changed
2022-04-18 21:03:09
@article{8f6ab918-16ee-423c-9a0a-75983ec3ba8d,
  abstract     = {{<p>Given the growing use of cerebrospinal fluid (CSF) beta-amyloid (Aß) and tau as biomarkers for early diagnosis of Alzheimer's disease (AD), it is essential that the diagnostic procedures are standardized and the results comparable across different laboratories. Preanalytical factors are reported to be the cause of at least 50% of the total variability. Among them, diurnal variability is a key issue and may have an impact on the comparability of the values obtained. The available studies on this issue are not conclusive so far. Fluctuations of CSF biomarkers in young healthy volunteers have been previously reported, while subsequent studies have not confirmed those observations in older subjects, the ones most likely to receive this test. The observed differences in circadian rhythms need to be further assessed not only in classical CSF biomarkers but also in novel forthcoming biomarkers. In this review, the existing data on the issue of diurnal variations of CSF classical biomarkers for AD will be analyzed, also evaluating the available data on new possible biomarkers.</p>}},
  author       = {{Cicognola, Claudia and Chiasserini, Davide and Parnetti, Lucilla}},
  issn         = {{1664-2295}},
  keywords     = {{Alzheimer's disease; Biomarkers; Cerebrospinal fluid; Circadian rhythm; Confounding factors; Diurnal variability}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{JUN}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Neurology}},
  title        = {{Preanalytical confounding factors in the analysis of cerebrospinal fluid biomarkers for Alzheimer's disease : The issue of diurnal variation}},
  url          = {{http://dx.doi.org/10.3389/fneur.2015.00143}},
  doi          = {{10.3389/fneur.2015.00143}},
  volume       = {{6}},
  year         = {{2015}},
}