Quantification of the in vivo brain ultrashort-T2* component in healthy volunteers
Deveshwar, Nikhil ; Yao, Jingwen ; Han, Misung ; Dwork, Nicholas ; Shen, Xin ; Ljungberg, Emil LU
; Caverzasi, Eduardo
; Cao, Peng
; Henry, Roland
and Green, Ari
, et al.
(2024)
In Magnetic Resonance in Medicine
- Abstract
Purpose: Recent work has shown MRI is able to measure and quantify signals of phospholipid membrane-bound protons associated with myelin in the human brain. This work seeks to develop an improved technique for characterizing this brain ultrashort- (Formula presented.) component in vivo accounting for (Formula presented.) weighting. Methods: Data from ultrashort echo time scans from 16 healthy volunteers with variable flip angles (VFA) were collected and fitted into an advanced regression model to quantify signal fraction, relaxation time, and frequency shift of the ultrashort- (Formula presented.) component. Results: The fitted components show intra-subject differences of different white matter structures and significantly elevated... (More)
Purpose: Recent work has shown MRI is able to measure and quantify signals of phospholipid membrane-bound protons associated with myelin in the human brain. This work seeks to develop an improved technique for characterizing this brain ultrashort- (Formula presented.) component in vivo accounting for (Formula presented.) weighting. Methods: Data from ultrashort echo time scans from 16 healthy volunteers with variable flip angles (VFA) were collected and fitted into an advanced regression model to quantify signal fraction, relaxation time, and frequency shift of the ultrashort- (Formula presented.) component. Results: The fitted components show intra-subject differences of different white matter structures and significantly elevated ultrashort- (Formula presented.) signal fraction in the corticospinal tracts measured at 0.09 versus 0.06 in other white matter structures and significantly elevated ultrashort- (Formula presented.) frequency shift in the body of the corpus callosum at (Formula presented.) 1.5 versus (Formula presented.) 2.0 ppm in other white matter structures. Conclusion: The significantly different measured components and measured (Formula presented.) relaxation time of the ultrashort- (Formula presented.) component suggest that this method is picking up novel signals from phospholipid membrane-bound protons.
(Less)
- author
- Deveshwar, Nikhil
; Yao, Jingwen
; Han, Misung
; Dwork, Nicholas
; Shen, Xin
; Ljungberg, Emil
LU
; Caverzasi, Eduardo
; Cao, Peng
; Henry, Roland
and Green, Ari
, et al. (More)
- Deveshwar, Nikhil
; Yao, Jingwen
; Han, Misung
; Dwork, Nicholas
; Shen, Xin
; Ljungberg, Emil
LU
; Caverzasi, Eduardo
; Cao, Peng
; Henry, Roland
; Green, Ari
and Larson, Peder E.Z.
(Less)
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- brain imaging, multicomponent fit model, myelin, ultrashort echo time, UTE
- in
- Magnetic Resonance in Medicine
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:38291598
- scopus:85183864103
- ISSN
- 0740-3194
- DOI
- 10.1002/mrm.30013
- language
- English
- LU publication?
- yes
- id
- 8f7165c3-af6e-434d-8887-d417e6eb294e
- date added to LUP
- 2024-02-27 12:26:38
- date last changed
- 2024-04-26 15:51:44
@article{8f7165c3-af6e-434d-8887-d417e6eb294e,
abstract = {{<p>Purpose: Recent work has shown MRI is able to measure and quantify signals of phospholipid membrane-bound protons associated with myelin in the human brain. This work seeks to develop an improved technique for characterizing this brain ultrashort- (Formula presented.) component in vivo accounting for (Formula presented.) weighting. Methods: Data from ultrashort echo time scans from 16 healthy volunteers with variable flip angles (VFA) were collected and fitted into an advanced regression model to quantify signal fraction, relaxation time, and frequency shift of the ultrashort- (Formula presented.) component. Results: The fitted components show intra-subject differences of different white matter structures and significantly elevated ultrashort- (Formula presented.) signal fraction in the corticospinal tracts measured at 0.09 versus 0.06 in other white matter structures and significantly elevated ultrashort- (Formula presented.) frequency shift in the body of the corpus callosum at (Formula presented.) 1.5 versus (Formula presented.) 2.0 ppm in other white matter structures. Conclusion: The significantly different measured components and measured (Formula presented.) relaxation time of the ultrashort- (Formula presented.) component suggest that this method is picking up novel signals from phospholipid membrane-bound protons.</p>}},
author = {{Deveshwar, Nikhil and Yao, Jingwen and Han, Misung and Dwork, Nicholas and Shen, Xin and Ljungberg, Emil and Caverzasi, Eduardo and Cao, Peng and Henry, Roland and Green, Ari and Larson, Peder E.Z.}},
issn = {{0740-3194}},
keywords = {{brain imaging; multicomponent fit model; myelin; ultrashort echo time; UTE}},
language = {{eng}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Magnetic Resonance in Medicine}},
title = {{Quantification of the in vivo brain ultrashort-T<sub>2</sub>* component in healthy volunteers}},
url = {{http://dx.doi.org/10.1002/mrm.30013}},
doi = {{10.1002/mrm.30013}},
year = {{2024}},
}