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Successful radioimmunotherapy of established syngeneic rat colon carcinoma with 211At-mAb.

Eriksson, Sophie LU ; Bäck, Tom ; Elgström, Erika LU ; Jensen, Holger ; Nilsson, Rune LU ; Lindegren, Sture and Tennvall, Jan LU (2013) In EJNMMI Research 3(1).
Abstract
Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered especially suitable for the treatment of small cell clusters and single cells, although lesions of different sizes may also be present in the patient. The aim of this study was primarily to evaluate the toxicity and secondarily in vivo efficacy of a 211At-labeled monoclonal antibody (mAb) directed against colon carcinoma with tumor diameters of approximately 10 mm.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
EJNMMI Research
volume
3
issue
1
article number
23
publisher
BioMed Central
external identifiers
  • pmid:23557183
  • scopus:84876850544
  • pmid:23557183
  • wos:000209435800023
ISSN
2191-219X
DOI
10.1186/2191-219X-3-23
language
English
LU publication?
yes
id
8f8c8939-94b4-4c96-808e-87c019826562 (old id 3734153)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23557183?dopt=Abstract
date added to LUP
2016-04-01 14:48:50
date last changed
2020-01-12 17:18:10
@article{8f8c8939-94b4-4c96-808e-87c019826562,
  abstract     = {Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered especially suitable for the treatment of small cell clusters and single cells, although lesions of different sizes may also be present in the patient. The aim of this study was primarily to evaluate the toxicity and secondarily in vivo efficacy of a 211At-labeled monoclonal antibody (mAb) directed against colon carcinoma with tumor diameters of approximately 10 mm.},
  author       = {Eriksson, Sophie and Bäck, Tom and Elgström, Erika and Jensen, Holger and Nilsson, Rune and Lindegren, Sture and Tennvall, Jan},
  issn         = {2191-219X},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {EJNMMI Research},
  title        = {Successful radioimmunotherapy of established syngeneic rat colon carcinoma with 211At-mAb.},
  url          = {https://lup.lub.lu.se/search/ws/files/4184006/4053663.pdf},
  doi          = {10.1186/2191-219X-3-23},
  volume       = {3},
  year         = {2013},
}