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Ribotyping of Clostridium difficile strains associated with nosocomial transmission and relapses in a Swedish County

Magnusson, Cecilia; Wullt, Marlene LU ; Lofgren, Sture; Iveroth, Peter; Akerlund, Tomas and Matussek, Andreas (2013) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica1988-01-01+01:00 121(2). p.153-157
Abstract
Clostridium difficile is an emerging threat in hospital environments. To analyse possible transmission and to distinguish between relapse and reinfection a collection of C. difficile isolates, sampled from 162 consecutive episodes of C. difficile infection, were PCR ribotyped. Two ribotypes (001 and 012) were prone to cause nosocomial acquisition. Moreover, ribotype 001 had a tendency to cause relapses as almost one in two patients with this ribotype had one or more relapses. By using PCR ribotyping strains inclined to cause relapses and strains associated with hospital transmission might be detected. This enables optimized hygiene measures and may improve the choice of treatment regimen.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Clostridium difficile, molecular epidemiology, ribotyping, transmission, CDI, hygiene measures
in
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica1988-01-01+01:00
volume
121
issue
2
pages
153 - 157
publisher
John Wiley & Sons
external identifiers
  • wos:000313830700009
  • scopus:84872665873
ISSN
1600-0463
DOI
10.1111/j.1600-0463.2012.02950.x
language
English
LU publication?
yes
id
8fa036f6-e086-4d9a-944d-d3450ae622c5 (old id 3590934)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23030627
date added to LUP
2013-03-20 14:23:18
date last changed
2019-03-05 01:11:19
@article{8fa036f6-e086-4d9a-944d-d3450ae622c5,
  abstract     = {Clostridium difficile is an emerging threat in hospital environments. To analyse possible transmission and to distinguish between relapse and reinfection a collection of C. difficile isolates, sampled from 162 consecutive episodes of C. difficile infection, were PCR ribotyped. Two ribotypes (001 and 012) were prone to cause nosocomial acquisition. Moreover, ribotype 001 had a tendency to cause relapses as almost one in two patients with this ribotype had one or more relapses. By using PCR ribotyping strains inclined to cause relapses and strains associated with hospital transmission might be detected. This enables optimized hygiene measures and may improve the choice of treatment regimen.},
  author       = {Magnusson, Cecilia and Wullt, Marlene and Lofgren, Sture and Iveroth, Peter and Akerlund, Tomas and Matussek, Andreas},
  issn         = {1600-0463},
  keyword      = {Clostridium difficile,molecular epidemiology,ribotyping,transmission,CDI,hygiene measures},
  language     = {eng},
  number       = {2},
  pages        = {153--157},
  publisher    = {John Wiley & Sons},
  series       = { APMIS : acta pathologica, microbiologica, et immunologica Scandinavica1988-01-01+01:00},
  title        = {Ribotyping of Clostridium difficile strains associated with nosocomial transmission and relapses in a Swedish County},
  url          = {http://dx.doi.org/10.1111/j.1600-0463.2012.02950.x},
  volume       = {121},
  year         = {2013},
}