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Impact of allograft ischemic time on long-term survival in lung transplantation : a Swedish monocentric study

Ghaidan, Haider LU orcid ; Fakhro, Mohammed LU and Lindstedt, Sandra LU (2020) In Scandinavian Cardiovascular Journal 54(5). p.322-329
Abstract

Purpose: The influence of allograft ischemic time (IT) on short- and long-term mortality remains under debate in lung transplantation (LTx). Due to a scarcity in donors, better understanding of IT might improve the outcome after LTx. Methods: Between January 1990 and June 2016; 307 patients underwent LTx at Lund university hospital, Sweden. The end-point used was death/Re-LTx assessed by Cox regression and Kaplan–Meier survival. Results: Kaplan–Meier survival for mean IT (min) between subgroups ≤120, 121–240, 241–360 and 361+ showed significant difference for pairwise-comparisons with superior outcome for IT between ≤120 and 240 min. Cox regression analyses for each hour of IT in patients with a limited survival up to 1- and 5-year had... (More)

Purpose: The influence of allograft ischemic time (IT) on short- and long-term mortality remains under debate in lung transplantation (LTx). Due to a scarcity in donors, better understanding of IT might improve the outcome after LTx. Methods: Between January 1990 and June 2016; 307 patients underwent LTx at Lund university hospital, Sweden. The end-point used was death/Re-LTx assessed by Cox regression and Kaplan–Meier survival. Results: Kaplan–Meier survival for mean IT (min) between subgroups ≤120, 121–240, 241–360 and 361+ showed significant difference for pairwise-comparisons with superior outcome for IT between ≤120 and 240 min. Cox regression analyses for each hour of IT in patients with a limited survival up to 1- and 5-year had a hazard ratio (HR) of 1.119 and 1.063 respectively (p <.05). Conclusions: In LTx, every 2-hour increase of IT is equivalent to an increased mortality of up to 24% within 5 years. LTx with an IT of ≤120 min had a superior survival in both 1- and 5 years in comparison to an IT of up to 360 min. Better application of IT provides a key role in improving LTx outcome.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
donor organ scarcity, ischemic time, Lung transplantation, survival
in
Scandinavian Cardiovascular Journal
volume
54
issue
5
pages
8 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85087351465
  • pmid:32573283
ISSN
1401-7431
DOI
10.1080/14017431.2020.1781240
language
English
LU publication?
yes
id
8fb79ddc-b304-4947-823d-81a03e0e6ad8
date added to LUP
2020-07-17 10:37:18
date last changed
2025-01-24 19:10:36
@article{8fb79ddc-b304-4947-823d-81a03e0e6ad8,
  abstract     = {{<p>Purpose: The influence of allograft ischemic time (IT) on short- and long-term mortality remains under debate in lung transplantation (LTx). Due to a scarcity in donors, better understanding of IT might improve the outcome after LTx. Methods: Between January 1990 and June 2016; 307 patients underwent LTx at Lund university hospital, Sweden. The end-point used was death/Re-LTx assessed by Cox regression and Kaplan–Meier survival. Results: Kaplan–Meier survival for mean IT (min) between subgroups ≤120, 121–240, 241–360 and 361+ showed significant difference for pairwise-comparisons with superior outcome for IT between ≤120 and 240 min. Cox regression analyses for each hour of IT in patients with a limited survival up to 1- and 5-year had a hazard ratio (HR) of 1.119 and 1.063 respectively (p &lt;.05). Conclusions: In LTx, every 2-hour increase of IT is equivalent to an increased mortality of up to 24% within 5 years. LTx with an IT of ≤120 min had a superior survival in both 1- and 5 years in comparison to an IT of up to 360 min. Better application of IT provides a key role in improving LTx outcome.</p>}},
  author       = {{Ghaidan, Haider and Fakhro, Mohammed and Lindstedt, Sandra}},
  issn         = {{1401-7431}},
  keywords     = {{donor organ scarcity; ischemic time; Lung transplantation; survival}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{5}},
  pages        = {{322--329}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Cardiovascular Journal}},
  title        = {{Impact of allograft ischemic time on long-term survival in lung transplantation : a Swedish monocentric study}},
  url          = {{http://dx.doi.org/10.1080/14017431.2020.1781240}},
  doi          = {{10.1080/14017431.2020.1781240}},
  volume       = {{54}},
  year         = {{2020}},
}