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Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies

Schranz, D. B.; Bekris, L; Landin-Olsson, M. LU ; Törn, C. LU ; Niläng, A.; Toll, Å; Sjöström, J.; Grönland, H. and Lernmark, Åke LU (2000) In Hormone and Metabolic Research 32(4). p.133-138
Abstract

A quantitative assay with microSepharose was used to determine GAD65Ab and IA-2Ab levels in 771 population-based patients diagnosed with diabetes mellitus at 15 to 34 years of age, and in 828 matched controls. Among the patients, 587 (76%) were classified with type I, 108 (14%) with type II, and 76 (10%) with unclassifiable diabetes. The levels above normal demonstrated a prevalence of GAD65Ab in 66% of type I diabetes, 50% of type II diabetes and 54% of unclassifiable patients and for IA-2Ab in 40%, 17% and 21%, respectively. Among the autoantibody-positive sera, the LADA patients had a lower GAD65Ab index (median 0.19, p < 0.0001) and IA-2Ab index (median 0.28, p < 0.0001) than the type I patients (median 0.37 and 0.66).... (More)

A quantitative assay with microSepharose was used to determine GAD65Ab and IA-2Ab levels in 771 population-based patients diagnosed with diabetes mellitus at 15 to 34 years of age, and in 828 matched controls. Among the patients, 587 (76%) were classified with type I, 108 (14%) with type II, and 76 (10%) with unclassifiable diabetes. The levels above normal demonstrated a prevalence of GAD65Ab in 66% of type I diabetes, 50% of type II diabetes and 54% of unclassifiable patients and for IA-2Ab in 40%, 17% and 21%, respectively. Among the autoantibody-positive sera, the LADA patients had a lower GAD65Ab index (median 0.19, p < 0.0001) and IA-2Ab index (median 0.28, p < 0.0001) than the type I patients (median 0.37 and 0.66). Patients with unclassifiable diabetes had a GAD65Ab (median 0.43) or IA-2Ab (median 0.63) index which was not different from the type I diabetes patients. Our data demonstrate that young adult new-onset LADA patients have low level GAD65Ab and IA-2Ab. The low-level autoantibodies may signify a less aggressive beta- cell autoimmunity, which may explain why these patients are often classified with type II or non-insulin-dependent diabetes.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Autoimmunity, Diabetes Mellitus, Islet Cell Autoantibodies, ROC Curve, Type I Diabetes, Type II Diabetes
in
Hormone and Metabolic Research
volume
32
issue
4
pages
6 pages
publisher
Georg Thieme Verlag
external identifiers
  • scopus:0034030240
ISSN
0018-5043
language
English
LU publication?
no
id
8fbeae57-ddc6-4c25-8132-a3ccda153204
date added to LUP
2017-09-06 15:29:18
date last changed
2017-09-06 15:29:18
@article{8fbeae57-ddc6-4c25-8132-a3ccda153204,
  abstract     = {<p>A quantitative assay with microSepharose was used to determine GAD65Ab and IA-2Ab levels in 771 population-based patients diagnosed with diabetes mellitus at 15 to 34 years of age, and in 828 matched controls. Among the patients, 587 (76%) were classified with type I, 108 (14%) with type II, and 76 (10%) with unclassifiable diabetes. The levels above normal demonstrated a prevalence of GAD65Ab in 66% of type I diabetes, 50% of type II diabetes and 54% of unclassifiable patients and for IA-2Ab in 40%, 17% and 21%, respectively. Among the autoantibody-positive sera, the LADA patients had a lower GAD65Ab index (median 0.19, p &lt; 0.0001) and IA-2Ab index (median 0.28, p &lt; 0.0001) than the type I patients (median 0.37 and 0.66). Patients with unclassifiable diabetes had a GAD65Ab (median 0.43) or IA-2Ab (median 0.63) index which was not different from the type I diabetes patients. Our data demonstrate that young adult new-onset LADA patients have low level GAD65Ab and IA-2Ab. The low-level autoantibodies may signify a less aggressive beta- cell autoimmunity, which may explain why these patients are often classified with type II or non-insulin-dependent diabetes.</p>},
  author       = {Schranz, D. B. and Bekris, L and Landin-Olsson, M. and Törn, C. and Niläng, A. and Toll, Å and Sjöström, J. and Grönland, H. and Lernmark, Åke},
  issn         = {0018-5043},
  keyword      = {Autoimmunity,Diabetes Mellitus,Islet Cell Autoantibodies,ROC Curve,Type I Diabetes,Type II Diabetes},
  language     = {eng},
  number       = {4},
  pages        = {133--138},
  publisher    = {Georg Thieme Verlag},
  series       = {Hormone and Metabolic Research},
  title        = {Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies},
  volume       = {32},
  year         = {2000},
}