135La as an Auger-electron emitter for targeted internal radiotherapy
(2018) In Physics in Medicine and Biology 63(1).- Abstract
135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to 135La therapy. 135La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 19 MBq A-1 (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered > 98 % of the 135La with an effective molar activity of 70 20 GBq mol-1. To better assess cellular and organ dosimetry... (More)
135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to 135La therapy. 135La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 19 MBq A-1 (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered > 98 % of the 135La with an effective molar activity of 70 20 GBq mol-1. To better assess cellular and organ dosimetry of this nuclide, we have calculated the x-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to calculate cellular S-factors. 135La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy.
(Less)
- author
- Fonslet, J. ; Lee, B. Q. ; Tran, T. A. LU ; Siragusa, M. ; Jensen, M. LU ; Kibédi, T. ; Stuchbery, A. E. and Severin, G. W.
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Auger therapy, isotope production, La-135, lanthanum, radionuclide therapy
- in
- Physics in Medicine and Biology
- volume
- 63
- issue
- 1
- article number
- 015026
- publisher
- IOP Publishing
- external identifiers
-
- scopus:85040309258
- pmid:29286003
- ISSN
- 0031-9155
- DOI
- 10.1088/1361-6560/aa9b44
- language
- English
- LU publication?
- yes
- id
- 8fc94978-3dde-462e-b003-917c1503e0f5
- date added to LUP
- 2018-02-05 12:06:55
- date last changed
- 2024-03-18 04:40:40
@article{8fc94978-3dde-462e-b003-917c1503e0f5, abstract = {{<p><sup>135</sup>La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to <sup>135</sup>La therapy. <sup>135</sup>La was produced by 16.5 MeV proton irradiation of metallic <sup>nat</sup>Ba on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 19 MBq A<sup>-1</sup> (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered > 98 % of the <sup>135</sup>La with an effective molar activity of 70 20 GBq mol<sup>-1</sup>. To better assess cellular and organ dosimetry of this nuclide, we have calculated the x-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to calculate cellular S-factors. <sup>135</sup>La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy.</p>}}, author = {{Fonslet, J. and Lee, B. Q. and Tran, T. A. and Siragusa, M. and Jensen, M. and Kibédi, T. and Stuchbery, A. E. and Severin, G. W.}}, issn = {{0031-9155}}, keywords = {{Auger therapy; isotope production; La-135; lanthanum; radionuclide therapy}}, language = {{eng}}, month = {{01}}, number = {{1}}, publisher = {{IOP Publishing}}, series = {{Physics in Medicine and Biology}}, title = {{<sup>135</sup>La as an Auger-electron emitter for targeted internal radiotherapy}}, url = {{http://dx.doi.org/10.1088/1361-6560/aa9b44}}, doi = {{10.1088/1361-6560/aa9b44}}, volume = {{63}}, year = {{2018}}, }