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135La as an Auger-electron emitter for targeted internal radiotherapy

Fonslet, J.; Lee, B. Q.; Tran, T. A. LU ; Siragusa, M.; Jensen, M. LU ; Kibédi, T.; Stuchbery, A. E. and Severin, G. W. (2018) In Physics in Medicine and Biology 63(1).
Abstract

135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to 135La therapy. 135La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 19 MBq A-1 (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered > 98 % of the 135La with an effective molar activity of 70 20 GBq mol-1. To better assess cellular and organ dosimetry... (More)

135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to 135La therapy. 135La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 19 MBq A-1 (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered > 98 % of the 135La with an effective molar activity of 70 20 GBq mol-1. To better assess cellular and organ dosimetry of this nuclide, we have calculated the x-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to calculate cellular S-factors. 135La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Auger therapy, isotope production, La-135, lanthanum, radionuclide therapy
in
Physics in Medicine and Biology
volume
63
issue
1
publisher
IOP Publishing
external identifiers
  • scopus:85040309258
  • pmid:29286003
ISSN
0031-9155
DOI
10.1088/1361-6560/aa9b44
language
English
LU publication?
yes
id
8fc94978-3dde-462e-b003-917c1503e0f5
date added to LUP
2018-02-05 12:06:55
date last changed
2018-05-29 11:38:34
@article{8fc94978-3dde-462e-b003-917c1503e0f5,
  abstract     = {<p><sup>135</sup>La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to <sup>135</sup>La therapy. <sup>135</sup>La was produced by 16.5 MeV proton irradiation of metallic <sup>nat</sup>Ba on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 19 MBq A<sup>-1</sup> (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered &gt; 98 % of the <sup>135</sup>La with an effective molar activity of 70 20 GBq mol<sup>-1</sup>. To better assess cellular and organ dosimetry of this nuclide, we have calculated the x-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to calculate cellular S-factors. <sup>135</sup>La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy.</p>},
  articleno    = {015026},
  author       = {Fonslet, J. and Lee, B. Q. and Tran, T. A. and Siragusa, M. and Jensen, M. and Kibédi, T. and Stuchbery, A. E. and Severin, G. W.},
  issn         = {0031-9155},
  keyword      = {Auger therapy,isotope production,La-135,lanthanum,radionuclide therapy},
  language     = {eng},
  month        = {01},
  number       = {1},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {<sup>135</sup>La as an Auger-electron emitter for targeted internal radiotherapy},
  url          = {http://dx.doi.org/10.1088/1361-6560/aa9b44},
  volume       = {63},
  year         = {2018},
}