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Ceramides : a potential cardiovascular biomarker in young adult childhood cancer survivors?

Broberg, Olof LU ; Weismann, Constance G. LU orcid ; Øra, Ingrid LU ; Wiebe, Thomas LU ; Laaksonen, Reijo and Liuba, Petru LU (2024) In European Heart Journal Open 4(2).
Abstract

Aims The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort. Methods Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardi- and results otoxic (C16:0, C18:0, C24:0, and C24:1), were analysed by mass spectrometry. The coronary event risk test 2 (CERT2) score was calculated from the ceramide data. Cardiac and carotid artery ultrasound data and lipid data available from previous studies of this cohort were used to study partial correlations with ceramide and CERT2 score data. All four... (More)

Aims The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort. Methods Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardi- and results otoxic (C16:0, C18:0, C24:0, and C24:1), were analysed by mass spectrometry. The coronary event risk test 2 (CERT2) score was calculated from the ceramide data. Cardiac and carotid artery ultrasound data and lipid data available from previous studies of this cohort were used to study partial correlations with ceramide and CERT2 score data. All four analysed ceramides were elevated in CCS compared with controls (P ≤ 0.012). The greatest difference was noted for C18:0, which was 33% higher in CCS compared with controls adjusted for sex, age, and body mass index (BMI) (P < 0.001). The CERT2 score was higher in CCS compared with controls (P < 0.001). In the CCS group, 35% had a high to very high CERT2 score (7-12) when compared with 9% in the control group (P < 0.001). The CCS subgroup with a CERT2 score ≥ 7 had higher heart rate, systolic blood pressure, and higher levels of apolipoprotein B compared with CCS with a CERT2 score < 6 (P ≤ 0.011). When adjusted for age, sex, and BMI, CERT2 score was significantly correlated with arterial stiffness, growth hormone, and cranial radiotherapy (P < 0.044). Conclusion Ceramides could be important biomarkers in understanding the pathophysiology of CVD and in predicting CVD disease risk in young adult CCS.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarker, Ceramides, Childhood cancer survivors
in
European Heart Journal Open
volume
4
issue
2
publisher
Oxford University Press
external identifiers
  • scopus:85191613314
  • pmid:38659666
ISSN
2752-4191
DOI
10.1093/ehjopen/oeae026
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.
id
8fe6091b-0d4f-4a90-9899-6155874e6d28
date added to LUP
2024-07-13 09:52:49
date last changed
2024-07-15 10:43:42
@article{8fe6091b-0d4f-4a90-9899-6155874e6d28,
  abstract     = {{<p>Aims The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort. Methods Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardi- and results otoxic (C16:0, C18:0, C24:0, and C24:1), were analysed by mass spectrometry. The coronary event risk test 2 (CERT2) score was calculated from the ceramide data. Cardiac and carotid artery ultrasound data and lipid data available from previous studies of this cohort were used to study partial correlations with ceramide and CERT2 score data. All four analysed ceramides were elevated in CCS compared with controls (P ≤ 0.012). The greatest difference was noted for C18:0, which was 33% higher in CCS compared with controls adjusted for sex, age, and body mass index (BMI) (P &lt; 0.001). The CERT2 score was higher in CCS compared with controls (P &lt; 0.001). In the CCS group, 35% had a high to very high CERT2 score (7-12) when compared with 9% in the control group (P &lt; 0.001). The CCS subgroup with a CERT2 score ≥ 7 had higher heart rate, systolic blood pressure, and higher levels of apolipoprotein B compared with CCS with a CERT2 score &lt; 6 (P ≤ 0.011). When adjusted for age, sex, and BMI, CERT2 score was significantly correlated with arterial stiffness, growth hormone, and cranial radiotherapy (P &lt; 0.044). Conclusion Ceramides could be important biomarkers in understanding the pathophysiology of CVD and in predicting CVD disease risk in young adult CCS.</p>}},
  author       = {{Broberg, Olof and Weismann, Constance G. and Øra, Ingrid and Wiebe, Thomas and Laaksonen, Reijo and Liuba, Petru}},
  issn         = {{2752-4191}},
  keywords     = {{Biomarker; Ceramides; Childhood cancer survivors}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{2}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal Open}},
  title        = {{Ceramides : a potential cardiovascular biomarker in young adult childhood cancer survivors?}},
  url          = {{http://dx.doi.org/10.1093/ehjopen/oeae026}},
  doi          = {{10.1093/ehjopen/oeae026}},
  volume       = {{4}},
  year         = {{2024}},
}