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Noninvasive ultrasound measurements of aortic intima-media thickness: Implications for in vivo study of aortic wall stress

Astrand, H; Sandgren, T; Rydén Ahlgren, Åsa LU and Lanne, T (2003) In Journal of Vascular Surgery 37(6). p.1270-1276
Abstract
Object: The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gender differences in wall stress. Methods: Sixty-five middle-aged healthy subjects were examined with B-mode ultrasound to determine the diameter and IMT in the infrarenal AA, common carotid artery (CCA), common femoral artery (CFA), and popliteal artery (PA). Blood pressure was measured noninvasively in the brachial artery. Wall stress was... (More)
Object: The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gender differences in wall stress. Methods: Sixty-five middle-aged healthy subjects were examined with B-mode ultrasound to determine the diameter and IMT in the infrarenal AA, common carotid artery (CCA), common femoral artery (CFA), and popliteal artery (PA). Blood pressure was measured noninvasively in the brachial artery. Wall stress was calculated according to the law of Laplace. Results: Intraobserver variability for the IMT in the AA showed a coefficient of variation of 11%. IMT was thickest in the AA compared with the CCA, CFA, and PA (P < .001). There was a gender difference in IMT in the CFA (P < .05) and PA (P < .01) but not in the AA. Greater wall stress was found in the AA than in the CCA (P < .001) and PA (P < .001), with men having greater wall stress in all studied arterial regions. Conclusions. Aortic IMT can be satisfactorily studied in vivo with noninvasive B-mode ultrasound. There are gender differences in IMT and wall stress, and the largest wall stress is found in the AA in men, which might be important in aneurysm development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Vascular Surgery
volume
37
issue
6
pages
1270 - 1276
publisher
Mosby
external identifiers
  • wos:000183359400021
  • pmid:12764275
  • scopus:0037734186
ISSN
1097-6809
DOI
10.1016/S0741-5214(02)75344-5
language
English
LU publication?
yes
id
108b2e95-fbd7-4128-a785-8e48f6897ec6 (old id 900316)
date added to LUP
2008-01-10 11:19:10
date last changed
2018-10-03 10:51:00
@article{108b2e95-fbd7-4128-a785-8e48f6897ec6,
  abstract     = {Object: The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gender differences in wall stress. Methods: Sixty-five middle-aged healthy subjects were examined with B-mode ultrasound to determine the diameter and IMT in the infrarenal AA, common carotid artery (CCA), common femoral artery (CFA), and popliteal artery (PA). Blood pressure was measured noninvasively in the brachial artery. Wall stress was calculated according to the law of Laplace. Results: Intraobserver variability for the IMT in the AA showed a coefficient of variation of 11%. IMT was thickest in the AA compared with the CCA, CFA, and PA (P &lt; .001). There was a gender difference in IMT in the CFA (P &lt; .05) and PA (P &lt; .01) but not in the AA. Greater wall stress was found in the AA than in the CCA (P &lt; .001) and PA (P &lt; .001), with men having greater wall stress in all studied arterial regions. Conclusions. Aortic IMT can be satisfactorily studied in vivo with noninvasive B-mode ultrasound. There are gender differences in IMT and wall stress, and the largest wall stress is found in the AA in men, which might be important in aneurysm development.},
  author       = {Astrand, H and Sandgren, T and Rydén Ahlgren, Åsa and Lanne, T},
  issn         = {1097-6809},
  language     = {eng},
  number       = {6},
  pages        = {1270--1276},
  publisher    = {Mosby},
  series       = {Journal of Vascular Surgery},
  title        = {Noninvasive ultrasound measurements of aortic intima-media thickness: Implications for in vivo study of aortic wall stress},
  url          = {http://dx.doi.org/10.1016/S0741-5214(02)75344-5},
  volume       = {37},
  year         = {2003},
}