Differential regulation of beta-defensin expression in human skin by microbial stimuli
(2005) In Journal of Immunology 174(8). p.4870-4879- Abstract
- In response to infection, epithelia mount an innate immune response that includes the production of antimicrobial peptides. However, the pathways that connect infection and inflammation with the induction of antimicrobial peptides in epithelia are not understood. We analyzed the molecular links between infection and the expression of three antimicrobial peptides of the beta-defensin family, human beta-defensin (hBD)-1, hBD-2, and hBD-3 in the human epidermis. After exposure to microbe-derived molecules, both monocytes and lymphocytes stimulated the epidermal expression of hBD-1, hBD-2, and hBD-3. The induced expression of hBD-3 was mediated by transactivation. of the epidermal growth factor receptor. The mechanisms of induction of hBD-1... (More)
- In response to infection, epithelia mount an innate immune response that includes the production of antimicrobial peptides. However, the pathways that connect infection and inflammation with the induction of antimicrobial peptides in epithelia are not understood. We analyzed the molecular links between infection and the expression of three antimicrobial peptides of the beta-defensin family, human beta-defensin (hBD)-1, hBD-2, and hBD-3 in the human epidermis. After exposure to microbe-derived molecules, both monocytes and lymphocytes stimulated the epidermal expression of hBD-1, hBD-2, and hBD-3. The induced expression of hBD-3 was mediated by transactivation. of the epidermal growth factor receptor. The mechanisms of induction of hBD-1 and hBD-3 were distinct from each other and from the IL-1-dependent induction of hBD-2 expression. Thus during inflammation, epidermal expression of beta-defensins is mediated by at least three different mechanisms. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/240110
- author
- Sørensen, Ole E LU ; Thapa, D R ; Rosenthal, A ; Liu, L D ; Roberts, A A and Ganz, T
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Immunology
- volume
- 174
- issue
- 8
- pages
- 4870 - 4879
- publisher
- American Association of Immunologists
- external identifiers
-
- wos:000228234600054
- pmid:15814714
- ISSN
- 1550-6606
- language
- English
- LU publication?
- no
- id
- 90223c0d-c401-4225-a750-83add0aa8766 (old id 240110)
- alternative location
- http://www.jimmunol.org/cgi/content/abstract/174/8/4870
- date added to LUP
- 2016-04-01 16:37:42
- date last changed
- 2018-11-21 20:42:53
@article{90223c0d-c401-4225-a750-83add0aa8766,
abstract = {{In response to infection, epithelia mount an innate immune response that includes the production of antimicrobial peptides. However, the pathways that connect infection and inflammation with the induction of antimicrobial peptides in epithelia are not understood. We analyzed the molecular links between infection and the expression of three antimicrobial peptides of the beta-defensin family, human beta-defensin (hBD)-1, hBD-2, and hBD-3 in the human epidermis. After exposure to microbe-derived molecules, both monocytes and lymphocytes stimulated the epidermal expression of hBD-1, hBD-2, and hBD-3. The induced expression of hBD-3 was mediated by transactivation. of the epidermal growth factor receptor. The mechanisms of induction of hBD-1 and hBD-3 were distinct from each other and from the IL-1-dependent induction of hBD-2 expression. Thus during inflammation, epidermal expression of beta-defensins is mediated by at least three different mechanisms.}},
author = {{Sørensen, Ole E and Thapa, D R and Rosenthal, A and Liu, L D and Roberts, A A and Ganz, T}},
issn = {{1550-6606}},
language = {{eng}},
number = {{8}},
pages = {{4870--4879}},
publisher = {{American Association of Immunologists}},
series = {{Journal of Immunology}},
title = {{Differential regulation of beta-defensin expression in human skin by microbial stimuli}},
url = {{http://www.jimmunol.org/cgi/content/abstract/174/8/4870}},
volume = {{174}},
year = {{2005}},
}